HIV-Infected Patients: Cross Site-Specific Hydrolysis of H3 and H4 Histones and Myelin Basic Protein with Antibodies against These Three Proteins.
H4 histones
HIV infected patients
and myelin basic protein
catalytic antibodies
cross-complexation and catalytic cross-reactivity
human blood antibodies
hydrolysis of H3
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
09 Jan 2021
09 Jan 2021
Historique:
received:
03
12
2020
revised:
03
01
2021
accepted:
05
01
2021
entrez:
13
1
2021
pubmed:
14
1
2021
medline:
7
9
2021
Statut:
epublish
Résumé
Histones play important roles in chromatin functioning and gene transcription, but in the intercellular space, they are harmful since they stimulate systemic inflammatory and toxic responses. Electrophoretically homogeneous IgGs against myelin basic protein (MBP), as well as H3 and H4 histones, were isolated from sera of HIV-infected patients. In contrast to known classical proteases, these IgGs split exclusively only histones and MBP but no other control proteins. Among 13 sites of hydrolysis of H3 by IgGs against H3 and 14 sites for anti-MBP IgGs, only two sites of the hydrolysis were the same. Between seven cleavage sites of H4 with IgGs against H4 and 9 sites of this histone hydrolysis by antibodies against MBP, only three sites were the same. The sites of hydrolysis of H3 (and H4) with abzymes against these histones and against MBP were different, but several expended protein clusters containing hydrolysis sites are partially overlapped. The existence of enzymatic cross-reactivity of abzymes against H3 and H4 and MBP represents a great menace to humans since due to cell apoptosis, histones constantly occur in human blood. They can hydrolyze MBP of the myelin sheath of axons and play a negative role in the pathogenesis of HIV-infected patients.
Identifiants
pubmed: 33435385
pii: molecules26020316
doi: 10.3390/molecules26020316
pmc: PMC7826842
pii:
doi:
Substances chimiques
Histones
0
Immunoglobulin G
0
MBP protein, human
0
Myelin Basic Protein
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Russian Foundation of Basic Research
ID : 20-34-70115
Organisme : Russian Foundation of Basic Research
ID : 18-04-00442 А
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