Chronic exposure to ethanol alters the expression of miR-155, miR-122 and miR-217 in alcoholic liver disease in an adult zebrafish model.
Animals
Biomarkers
/ metabolism
Disease Models, Animal
Ethanol
/ pharmacology
Female
Gene Expression Regulation
Humans
Interleukin-10
/ genetics
Interleukin-1beta
/ genetics
Liver
/ drug effects
Liver Diseases, Alcoholic
/ genetics
Male
MicroRNAs
/ genetics
Triglycerides
/ metabolism
Tumor Necrosis Factor-alpha
/ genetics
Zebrafish
Alcoholic liver disease
Ethanol
Zebrafish
miR-122
miR-155
miR-217
Journal
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
ISSN: 1366-5804
Titre abrégé: Biomarkers
Pays: England
ID NLM: 9606000
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
pubmed:
14
1
2021
medline:
3
11
2021
entrez:
13
1
2021
Statut:
ppublish
Résumé
The aim of this study was to evaluate the hepatic and circulating expression of miR-155, miR-122 and miR-217 in a model of chronic exposure to ethanol in adult zebrafish. Wild-type adult zebrafish were divided into two groups ( We observed hepatic lesions and increased accumulation of hepatic lipids in the EG. The expression of Chronic exposure to ethanol in zebrafish leads to altered hepatic and circulating expression of miR-155, miR-122 and miR-217. This confirms its potential as a biomarker and therapeutic target.
Identifiants
pubmed: 33435755
doi: 10.1080/1354750X.2021.1874051
doi:
Substances chimiques
Biomarkers
0
Interleukin-1beta
0
MIRN122 microRNA, zebrafish
0
MIRN155 microRNA, zebrafish
0
MicroRNAs
0
Triglycerides
0
Tumor Necrosis Factor-alpha
0
Interleukin-10
130068-27-8
Ethanol
3K9958V90M
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM