Progress towards non-small-cell lung cancer models that represent clinical evolutionary trajectories.
cancer evolution
cell lines
genetically engineered mouse models
model systems
organoids
patient-derived xenografts
Journal
Open biology
ISSN: 2046-2441
Titre abrégé: Open Biol
Pays: England
ID NLM: 101580419
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
entrez:
13
1
2021
pubmed:
14
1
2021
medline:
4
11
2021
Statut:
ppublish
Résumé
Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide. Although advances are being made towards earlier detection and the development of impactful targeted therapies and immunotherapies, the 5-year survival of patients with advanced disease is still below 20%. Effective cancer research relies on pre-clinical model systems that accurately reflect the evolutionary course of disease progression and mimic patient responses to therapy. Here, we review pre-clinical models, including genetically engineered mouse models and patient-derived materials, such as cell lines, primary cell cultures, explant cultures and xenografts, that are currently being used to interrogate NSCLC evolution from pre-invasive disease through locally invasive cancer to the metastatic colonization of distant organ sites.
Identifiants
pubmed: 33435818
doi: 10.1098/rsob.200247
pmc: PMC7881177
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
200247Subventions
Organisme : Medical Research Council
ID : FC001169
Pays : United Kingdom
Organisme : Cancer Research UK
ID : A27412
Pays : United Kingdom
Organisme : Cancer Research UK
ID : FC001169
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC001169
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 209199/Z/17/Z
Pays : United Kingdom
Références
Clin Cancer Res. 2011 Jan 1;17(1):134-41
pubmed: 21081655
Am J Clin Pathol. 1955 Oct;25(10):1107-12
pubmed: 13258519
Nat Commun. 2017 Feb 01;8:14381
pubmed: 28146145
Cell Stem Cell. 2020 Dec 3;27(6):905-919.e10
pubmed: 33142113
Nature. 2018 Feb 22;554(7693):544-548
pubmed: 29443960
Nature. 2019 May;569(7757):503-508
pubmed: 31068700
Cell Death Dis. 2018 Feb 7;9(2):177
pubmed: 29415996
Nat Biotechnol. 2019 Mar;37(3):314-322
pubmed: 30778230
Cancer Res. 2005 Nov 15;65(22):10280-8
pubmed: 16288016
Nat Biotechnol. 2021 Jan;39(1):64-73
pubmed: 32719479
Toxicol In Vitro. 2018 Mar;47:137-146
pubmed: 29155131
Cancer Prev Res (Phila). 2012 Feb;5(2):283-9
pubmed: 22086679
Exp Cell Res. 1997 Aug 25;235(1):245-53
pubmed: 9281374
Nature. 2019 Jul;571(7766):570-575
pubmed: 31243362
Mol Cancer Res. 2013 Jun;11(6):638-50
pubmed: 23449933
Clin Cancer Res. 2003 Sep 15;9(11):4227-39
pubmed: 14519650
PLoS One. 2015 Apr 10;10(4):e0122823
pubmed: 25860262
Am J Pathol. 1991 Aug;139(2):413-22
pubmed: 1651059
Nat Biotechnol. 2010 Jun;28(6):585-93
pubmed: 20495549
Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21727-21731
pubmed: 31591243
Nat Methods. 2017 Jul;14(7):737-742
pubmed: 28530655
Cell Rep. 2017 Oct 10;21(2):508-516
pubmed: 29020635
Am J Respir Crit Care Med. 2017 Jun 1;195(11):1494-1508
pubmed: 28199128
Am J Respir Cell Mol Biol. 2014 Apr;50(4):767-76
pubmed: 24191670
Cancer Res. 1987 Oct 1;47(19):5132-40
pubmed: 3621199
J Natl Cancer Inst. 2010 Sep 8;102(17):1310-21
pubmed: 20679594
N Engl J Med. 2017 Jun 1;376(22):2109-2121
pubmed: 28445112
Cell Stem Cell. 2020 Apr 2;26(4):482-502
pubmed: 32243808
Nat Commun. 2015 Feb 27;6:6169
pubmed: 25721094
Oncoimmunology. 2019 Aug 15;8(11):e1648170
pubmed: 31646094
Cancer Res. 2017 Apr 15;77(8):2029-2039
pubmed: 28202521
Cancer Res. 1978 Jul;38(7):2084-90
pubmed: 418873
Nature. 2011 May 5;473(7345):101-4
pubmed: 21471965
Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7160-5
pubmed: 21474781
Cell Rep. 2015 Jan 13;10(2):239-52
pubmed: 25558064
Development. 2017 Mar 1;144(5):755-766
pubmed: 28246210
Cell Rep. 2020 May 5;31(5):107588
pubmed: 32375033
Am J Respir Cell Mol Biol. 2012 Mar;46(3):269-82
pubmed: 22180870
Nature. 2014 Jul 31;511(7511):543-50
pubmed: 25079552
Nature. 2017 May 18;545(7654):355-359
pubmed: 28489818
Nature. 2007 Aug 16;448(7155):807-10
pubmed: 17676035
EMBO J. 2019 Feb 15;38(4):
pubmed: 30643021
Cancer Res. 1955 Jan;15(1):38-51
pubmed: 13231073
Cell. 2018 Feb 8;172(4):841-856.e16
pubmed: 29395328
Cancer Res. 2014 May 1;74(9):2377-84
pubmed: 24717177
J Immunol. 2004 Mar 1;172(5):2731-8
pubmed: 14978070
Am J Respir Cell Mol Biol. 2018 Aug;59(2):237-245
pubmed: 29447458
Cancer Treat Rep. 1977 Nov;61(8):1459-70
pubmed: 922751
Nature. 2001 Apr 26;410(6832):1111-6
pubmed: 11323676
Blood. 2005 Sep 1;106(5):1565-73
pubmed: 15920010
J Thorac Oncol. 2017 Feb;12(2):397-402
pubmed: 27507192
Cancer. 1951 Sep;4(5):1015-24
pubmed: 14879368
Clin Cancer Res. 2020 Jul 1;26(13):3431-3442
pubmed: 32209571
Proc Natl Acad Sci U S A. 2010 May 4;107(18):8352-6
pubmed: 20404174
Cancer Cell. 2016 Oct 10;30(4):519-532
pubmed: 27728803
Nat Med. 2019 Mar;25(3):517-525
pubmed: 30664780
N Engl J Med. 2016 Nov 10;375(19):1823-1833
pubmed: 27718847
Am J Physiol Lung Cell Mol Physiol. 2019 Sep 1;317(3):L424-L430
pubmed: 31364371
Cancer Discov. 2020 Oct;10(10):1489-1499
pubmed: 32690541
Cancer Treat Rev. 2018 Apr;65:1-10
pubmed: 29477930
Cancer Res. 2007 Oct 15;67(20):10027-37
pubmed: 17942937
Ann Thorac Surg. 1996 Jul;62(1):246-50
pubmed: 8678651
Curr Opin Genet Dev. 2019 Feb;54:88-96
pubmed: 31078083
Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6409-E6417
pubmed: 27702896
Lab Invest. 1962 Aug;11:638-52
pubmed: 14490970
PLoS One. 2018 May 17;13(5):e0197129
pubmed: 29771943
PLoS One. 2010 Jun 10;5(6):e11022
pubmed: 20548776
Int J Cancer. 2018 Jul 1;143(1):160-166
pubmed: 29569246
Nat Rev Cancer. 2014 Aug;14(8):535-46
pubmed: 25056707
Cancer Cell. 2015 May 11;27(5):698-711
pubmed: 25936644
Nat Commun. 2018 Aug 10;9(1):3196
pubmed: 30097571
Genes Dev. 2020 Aug 1;34(15-16):1017-1032
pubmed: 32747478
J Natl Cancer Inst. 1973 Nov;51(5):1417-23
pubmed: 4357758
Am J Respir Cell Mol Biol. 2008 Nov;39(5):591-7
pubmed: 18539954
J Clin Invest. 2012 Mar;122(3):899-910
pubmed: 22293174
Cancer Prev Res (Phila). 2017 Sep;10(9):514-524
pubmed: 28754664
J Natl Cancer Inst. 1971 Sep;47(3):697-701
pubmed: 5157586
J Thorac Cardiovasc Surg. 2007 Feb;133(2):303-8
pubmed: 17258552
Nat Commun. 2019 Nov 29;10(1):5472
pubmed: 31784532
Eur J Cancer. 2016 Jul;62:132-7
pubmed: 27189322
Respir Investig. 2020 Sep;58(5):344-354
pubmed: 32586780
Cell. 2018 Sep 6;174(6):1586-1598.e12
pubmed: 30100188
Environ Res. 1997;74(2):150-8
pubmed: 9339228
Carcinogenesis. 2016 May;37(5):452-60
pubmed: 26964870
Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4910-5
pubmed: 22411819
Clin Cancer Res. 1999 May;5(5):991-1000
pubmed: 10353731
Sci Transl Med. 2020 Jun 24;12(549):
pubmed: 32581131
Nature. 2020 Feb;578(7794):266-272
pubmed: 31996850
Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4952-7
pubmed: 24586047
Cell Syst. 2020 Oct 21;11(4):393-401.e2
pubmed: 32937114
Nature. 2018 Mar 8;555(7695):251-255
pubmed: 29489752
Nat Rev Cancer. 2020 Mar;20(3):174-186
pubmed: 31980749
Am J Physiol. 1991 Aug;261(2 Pt 1):L70-6
pubmed: 1872417
Int J Cancer. 2017 Feb 1;140(3):662-673
pubmed: 27750381
Nature. 2015 Jun 18;522(7556):345-348
pubmed: 25822788
Cancer Sci. 2013 Dec;104(12):1560-6
pubmed: 24106881
PLoS One. 2013 Nov 11;8(11):e78823
pubmed: 24244370
Cancer Cell. 2003 Aug;4(2):111-20
pubmed: 12957286
Cancer Prev Res (Phila). 2019 Aug;12(8):507-516
pubmed: 31101634
Sci Rep. 2017 Jul 27;7(1):6689
pubmed: 28751748
J Clin Oncol. 2011 Apr 20;29(12):1556-63
pubmed: 21422424
J Thorac Oncol. 2016 Mar;11(3):287-99
pubmed: 26723239
Cell Rep. 2017 Dec 12;21(11):3298-3309
pubmed: 29241554
Int J Cancer. 2018 Jul 1;143(1):88-99
pubmed: 29341112
Ann Oncol. 2016 Jun;27(6):1155-1160
pubmed: 27013395
Dis Model Mech. 2019 Feb 12;12(2):
pubmed: 30760495
Adv Cancer Res. 1975;21:1-58
pubmed: 1108612
Cancers (Basel). 2018 Mar 14;10(3):
pubmed: 29538329
Nat Cancer. 2020 Mar;1(3):359-369
pubmed: 33345196
Cancer Res. 2018 Sep 1;78(17):5124-5134
pubmed: 29986997
Nat Med. 2016 Mar;22(3):262-9
pubmed: 26828195
Nat Commun. 2014 Mar 25;5:3472
pubmed: 24668028
Cancer Cell. 2020 Aug 10;38(2):212-228.e13
pubmed: 32707078
Clin Cancer Res. 2010 Mar 1;16(5):1442-51
pubmed: 20179238
Cell. 2020 May 14;181(4):848-864.e18
pubmed: 32298651
Dis Model Mech. 2017 Sep 1;10(9):1061-1074
pubmed: 28883015
Am J Respir Cell Mol Biol. 2020 Jun;62(6):681-691
pubmed: 31991090
J Clin Oncol. 2008 Jul 20;26(21):3552-9
pubmed: 18506026
Carcinogenesis. 1997 Mar;18(3):575-86
pubmed: 9067559
Methods Mol Biol. 2019;1953:241-252
pubmed: 30912026
Nat Rev Drug Discov. 2020 Aug;19(8):533-552
pubmed: 32528145
Nat Commun. 2019 Apr 23;10(1):1856
pubmed: 31015447
Nat Med. 2018 Aug;24(8):1277-1289
pubmed: 29988129
Oncotarget. 2017 Mar 21;8(12):18885-18900
pubmed: 27935865
Toxicol Pathol. 1991;19(2):168-75
pubmed: 1771369
ACS Nano. 2015 Mar 24;9(3):2377-89
pubmed: 25703655
Genes Dev. 2001 Dec 15;15(24):3243-8
pubmed: 11751630
Neoplasia. 2015 Sep;17(9):735-741
pubmed: 26476081
Nature. 2012 Sep 27;489(7417):519-25
pubmed: 22960745
Nat Genet. 2018 Apr;50(4):483-486
pubmed: 29610476
Nature. 2015 Jan 22;517(7535):489-92
pubmed: 25363767
Cell Rep. 2020 May 5;31(5):107550
pubmed: 32375028
Nat Med. 2017 Mar;23(3):291-300
pubmed: 28191885
PLoS One. 2008 May 07;3(5):e2125
pubmed: 18461184
Nature. 2020 Dec;588(7839):670-675
pubmed: 33238290
JCO Precis Oncol. 2017;2017:
pubmed: 29333526
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
PLoS One. 2013;8(2):e56010
pubmed: 23418494
J Clin Oncol. 2019 Oct 1;37(28):2518-2527
pubmed: 31154919
Clin Cancer Res. 2015 Mar 1;21(5):1172-82
pubmed: 25549722
Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19893-7
pubmed: 19064915
Nature. 2018 Aug;560(7718):325-330
pubmed: 30089904
J Clin Invest. 2013 Jul;123(7):3025-36
pubmed: 23921127
Br J Cancer Suppl. 1980 Apr;4:142-5
pubmed: 6252930
Oncotarget. 2017 Feb 14;8(7):11114-11126
pubmed: 28052041
Nat Commun. 2019 Sep 5;10(1):3991
pubmed: 31488816
Cancer Cell Int. 2019 Jan 29;19:21
pubmed: 30718976
Sci Rep. 2017 Nov 13;7(1):15454
pubmed: 29133824
Cancer Res. 1968 Jan;28(1):104-24
pubmed: 5635364
J Transl Med. 2016 Feb 29;14:61
pubmed: 26928703
Trends Cancer. 2020 Jul;6(7):569-579
pubmed: 32312681
Nat Rev Cancer. 2019 Mar;19(3):133-150
pubmed: 30755690
Respir Res. 2019 Aug 23;20(1):196
pubmed: 31443657
Genes Dev. 2006 Jun 1;20(11):1496-510
pubmed: 16705038
In Vitro. 1982 Jul;18(7):633-42
pubmed: 7141447
Nat Commun. 2017 Apr 07;8:14922
pubmed: 28387316
Science. 2010 Jun 25;328(5986):1662-8
pubmed: 20576885
Nat Med. 2015 Mar;21(3):256-62
pubmed: 25706875
Lung Cancer. 2019 Nov;137:113-122
pubmed: 31568888
FASEB J. 2018 Mar;32(3):1537-1549
pubmed: 29146734
Cancer Res. 2015 Dec 15;75(24):5378-91
pubmed: 26567140
Elife. 2019 May 29;8:
pubmed: 31140976
Br J Cancer. 2014 Sep 9;111(6):1021-46
pubmed: 25117809
Cancer Cell. 2020 Aug 10;38(2):229-246.e13
pubmed: 32707077
Cell Rep. 2014 Jul 10;8(1):40-9
pubmed: 24953650
Science. 2018 Mar 9;359(6380):1118-1123
pubmed: 29420258
Nat Commun. 2016 Jun 02;7:11739
pubmed: 27252083
Cancer Cell. 2011 Jan 18;19(1):72-85
pubmed: 21251614