Diagnostic role of CXCL13 and CSF serology in patients with neurosyphilis.
diagnosis
serology
syphilis
Journal
Sexually transmitted infections
ISSN: 1472-3263
Titre abrégé: Sex Transm Infect
Pays: England
ID NLM: 9805554
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
09
09
2020
revised:
14
12
2020
accepted:
22
12
2020
pubmed:
14
1
2021
medline:
1
12
2021
entrez:
13
1
2021
Statut:
ppublish
Résumé
Considering the unknown prevalence of neurosyphilis in West China, and the confusing diagnosis of neurosyphilis, the role of CSF_CXCL13 and syphilis serology was studied to provide a more accurate reference for the clinical detection and diagnosis of neurosyphilis. A retrospective data set I was used to investigate the prevalence of neurosyphilis, as well as the laboratory characteristics of 244 patients. Besides, to explore the diagnostic value of CSF_CXCL13 and syphilis serology for neurosyphilis, another 116 CSF_serum paired samples (data set II) were collected from 44 neurosyphilis and 72 non-neurosyphilis/syphilis patients. About 6.25% (156 out of 2494) syphilis was neurosyphilis. When Due to the lack of ideal biomarkers for neurosyphilis, the importance of syphilis serology cannot be ignored, and their combination with CSF_CXCL13 or other biomarkers should be further investigated.
Sections du résumé
BACKGROUND
Considering the unknown prevalence of neurosyphilis in West China, and the confusing diagnosis of neurosyphilis, the role of CSF_CXCL13 and syphilis serology was studied to provide a more accurate reference for the clinical detection and diagnosis of neurosyphilis.
METHODS
A retrospective data set I was used to investigate the prevalence of neurosyphilis, as well as the laboratory characteristics of 244 patients. Besides, to explore the diagnostic value of CSF_CXCL13 and syphilis serology for neurosyphilis, another 116 CSF_serum paired samples (data set II) were collected from 44 neurosyphilis and 72 non-neurosyphilis/syphilis patients.
RESULTS
About 6.25% (156 out of 2494) syphilis was neurosyphilis. When
CONCLUSION
Due to the lack of ideal biomarkers for neurosyphilis, the importance of syphilis serology cannot be ignored, and their combination with CSF_CXCL13 or other biomarkers should be further investigated.
Identifiants
pubmed: 33436504
pii: sextrans-2020-054778
doi: 10.1136/sextrans-2020-054778
doi:
Substances chimiques
Biomarkers
0
CXCL13 protein, human
0
Chemokine CXCL13
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
485-489Informations de copyright
© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.