Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
12 01 2021
Historique:
received: 16 04 2020
accepted: 10 12 2020
entrez: 13 1 2021
pubmed: 14 1 2021
medline: 22 1 2021
Statut: epublish

Résumé

Anti-PD-1 therapy is used as a front-line treatment for many cancers, but mechanistic insight into this therapy resistance is still lacking. Here we generate a humanized (Hu)-mouse melanoma model by injecting fetal liver-derived CD34

Identifiants

pubmed: 33436641
doi: 10.1038/s41467-020-20600-7
pii: 10.1038/s41467-020-20600-7
pmc: PMC7804257
doi:

Substances chimiques

Immune Checkpoint Inhibitors 0
Programmed Cell Death 1 Receptor 0
Sunitinib V99T50803M

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

346

Subventions

Organisme : NCI NIH HHS
ID : R01 CA165065
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA140043
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA010815
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA114046
Pays : United States
Organisme : NCI NIH HHS
ID : R50 CA211199
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA174523
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA224070
Pays : United States

Commentaires et corrections

Type : CommentIn

Références

Cell. 2017 Nov 2;171(4):934-949.e16
pubmed: 29033130
Nat Biotechnol. 2014 Apr;32(4):364-72
pubmed: 24633240
Cell Metab. 2019 Mar 5;29(3):769-783.e4
pubmed: 30713110
Mol Ther. 2014 Jan;22(1):42-51
pubmed: 24077034
Cancer Immunol Res. 2019 Jun;7(6):1025-1035
pubmed: 31043414
Cancer Res. 2005 Oct 15;65(20):9328-37
pubmed: 16230395
J Infect Dis. 2013 Nov;208 Suppl 2:S125-30
pubmed: 24151318
Methods Mol Biol. 2018;1711:243-259
pubmed: 29344893
Semin Cancer Biol. 2009 Apr;19(2):92-6
pubmed: 19049876
FASEB J. 2018 Mar;32(3):1537-1549
pubmed: 29146734
Cell. 2017 Feb 9;168(4):707-723
pubmed: 28187290
Nat Commun. 2017 Sep 19;8(1):592
pubmed: 28928380
Nature. 2020 Jan;577(7791):549-555
pubmed: 31942075
Mol Pharm. 2011 Dec 5;8(6):2039-49
pubmed: 22067046
Genome Biol. 2014;15(12):550
pubmed: 25516281
Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2842-5
pubmed: 8464898
Immunohorizons. 2020 Aug 20;4(8):508-519
pubmed: 32819967
Nature. 2017 Jul 6;547(7661):94-98
pubmed: 28636589
Exp Dermatol. 2017 Jan;26(1):11-17
pubmed: 27305467
Cancer Growth Metastasis. 2015 Oct 06;8(Suppl 1):81-94
pubmed: 26483610
Clin Cancer Res. 2018 Oct 15;24(20):4960-4967
pubmed: 29685882
Clin Cancer Res. 2008 Oct 15;14(20):6674-82
pubmed: 18927310
Nature. 2018 Aug;560(7718):382-386
pubmed: 30089911
Clin Cancer Res. 2019 Sep 1;25(17):5191-5201
pubmed: 30923036
Bioinformatics. 2015 Sep 15;31(18):2963-71
pubmed: 25987567
Annu Rev Pathol. 2017 Jan 24;12:187-215
pubmed: 27959627
Clin Cancer Res. 2009 Mar 15;15(6):2148-57
pubmed: 19276286
Br J Cancer. 2018 Jan;118(1):9-16
pubmed: 29319049
Oncoimmunology. 2015 Nov 5;5(3):e1083670
pubmed: 27141336
Am J Pathol. 2010 Aug;177(2):1031-41
pubmed: 20616342
Nat Med. 2019 Mar;25(3):454-461
pubmed: 30804515
Front Immunol. 2017 Apr 12;8:424
pubmed: 28446910
Nat Commun. 2017 Sep 19;8(1):607
pubmed: 28928360
Nature. 2017 May 4;545(7652):60-65
pubmed: 28397821
Br J Cancer. 2015 Jul 14;113(2):327-35
pubmed: 26042934
Am Soc Clin Oncol Educ Book. 2019 Jan;39:147-164
pubmed: 31099674
Trends Cancer. 2020 May;6(5):432-441
pubmed: 32348738
Front Oncol. 2018 Mar 28;8:86
pubmed: 29644214
Invest New Drugs. 2019 Dec;37(6):1198-1206
pubmed: 30725388
Oncoimmunology. 2017 Mar 7;6(8):e1299303
pubmed: 28919986
Infect Immun. 2016 Aug 19;84(9):2449-62
pubmed: 27297390
Phys Med Biol. 2019 Jan 16;64(2):025017
pubmed: 30561383
J Immunol. 2014 Mar 15;192(6):2892-903
pubmed: 24523508
Clin Cancer Res. 2015 Apr 1;21(7):1652-64
pubmed: 25617424
Front Med (Lausanne). 2018 Sep 25;5:271
pubmed: 30320116
Front Immunol. 2018 Jun 08;9:1305
pubmed: 29937769

Auteurs

Rajasekharan Somasundaram (R)

The Wistar Institute, Philadelphia, PA, USA. Shyam@wistar.org.

Thomas Connelly (T)

The Wistar Institute, Philadelphia, PA, USA.

Robin Choi (R)

The Wistar Institute, Philadelphia, PA, USA.

Hyeree Choi (H)

The Wistar Institute, Philadelphia, PA, USA.

Anastasia Samarkina (A)

The Wistar Institute, Philadelphia, PA, USA.

Ling Li (L)

The Wistar Institute, Philadelphia, PA, USA.

Elizabeth Gregorio (E)

The Wistar Institute, Philadelphia, PA, USA.

Yeqing Chen (Y)

The Wistar Institute, Philadelphia, PA, USA.

Rohit Thakur (R)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

Mohamed Abdel-Mohsen (M)

The Wistar Institute, Philadelphia, PA, USA.

Marilda Beqiri (M)

The Wistar Institute, Philadelphia, PA, USA.

Meaghan Kiernan (M)

The Wistar Institute, Philadelphia, PA, USA.

Michela Perego (M)

The Wistar Institute, Philadelphia, PA, USA.

Fang Wang (F)

The Wistar Institute, Philadelphia, PA, USA.

Min Xiao (M)

The Wistar Institute, Philadelphia, PA, USA.

Patricia Brafford (P)

The Wistar Institute, Philadelphia, PA, USA.

Xue Yang (X)

The Wistar Institute, Philadelphia, PA, USA.

Xiaowei Xu (X)

Department of Pathology and Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Anthony Secreto (A)

Department of Medicine, Stem Cell and Xenograft Core, University of Pennsylvania, Philadelphia, PA, USA.

Gwenn Danet-Desnoyers (G)

Department of Medicine, Stem Cell and Xenograft Core, University of Pennsylvania, Philadelphia, PA, USA.

Daniel Traum (D)

Department of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Klaus H Kaestner (KH)

Department of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Alexander C Huang (AC)

Department of Pathology and Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Denitsa Hristova (D)

The Wistar Institute, Philadelphia, PA, USA.

Joshua Wang (J)

The Wistar Institute, Philadelphia, PA, USA.

Mizuho Fukunaga-Kalabis (M)

The Wistar Institute, Philadelphia, PA, USA.

Clemens Krepler (C)

The Wistar Institute, Philadelphia, PA, USA.

Fang Ping-Chen (F)

The Wistar Institute, Philadelphia, PA, USA.

Xiangyang Zhou (X)

The Wistar Institute, Philadelphia, PA, USA.

Alexis Gutierrez (A)

The Wistar Institute, Philadelphia, PA, USA.

Vito W Rebecca (VW)

The Wistar Institute, Philadelphia, PA, USA.

Prashanthi Vonteddu (P)

The Wistar Institute, Philadelphia, PA, USA.

Farokh Dotiwala (F)

The Wistar Institute, Philadelphia, PA, USA.

Shashi Bala (S)

The Wistar Institute, Philadelphia, PA, USA.

Sonali Majumdar (S)

The Wistar Institute, Philadelphia, PA, USA.

Harsh Dweep (H)

The Wistar Institute, Philadelphia, PA, USA.

Jayamanna Wickramasinghe (J)

The Wistar Institute, Philadelphia, PA, USA.

Andrew V Kossenkov (AV)

The Wistar Institute, Philadelphia, PA, USA.

Jorge Reyes-Arbujas (J)

The Wistar Institute, Philadelphia, PA, USA.

Kenisha Santiago (K)

The Wistar Institute, Philadelphia, PA, USA.

Tran Nguyen (T)

The Wistar Institute, Philadelphia, PA, USA.

Johannes Griss (J)

Division of Immunology, Allergy and Infectious Diseases (DIAID), Department of Dermatology, Medical University of Vienna, Vienna, Austria.

Frederick Keeney (F)

The Wistar Institute, Philadelphia, PA, USA.

James Hayden (J)

The Wistar Institute, Philadelphia, PA, USA.

Brian J Gavin (BJ)

The Wistar Institute, Philadelphia, PA, USA.

David Weiner (D)

The Wistar Institute, Philadelphia, PA, USA.

Luis J Montaner (LJ)

The Wistar Institute, Philadelphia, PA, USA.

Qin Liu (Q)

The Wistar Institute, Philadelphia, PA, USA.

Lukas Peiffer (L)

University of Duisburg-Essen, Essen, Germany.

Jürgen Becker (J)

University of Duisburg-Essen, Essen, Germany.

Elizabeth M Burton (EM)

Department of Surgical Oncology, MD Anderson Cancer Center, Houston, TX, USA.

Michael A Davies (MA)

Department of Melanoma Medical Oncology, University of California, San Francisco, CA, USA.

Michael T Tetzlaff (MT)

Department of Pathology and Dermatology, University of California, San Francisco, CA, USA.

Kar Muthumani (K)

The Wistar Institute, Philadelphia, PA, USA.
GeneOne Life Science Inc., Fort Washington, PA, USA.

Jennifer A Wargo (JA)

Department of Surgical Oncology, MD Anderson Cancer Center, Houston, TX, USA.

Dmitry Gabrilovich (D)

AstraZeneca, Gaithersburg, MD, USA.

Meenhard Herlyn (M)

The Wistar Institute, Philadelphia, PA, USA. Herlynm@wistar.org.

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Classifications MeSH