In vivo intervertebral disc deformation: intratissue strain patterns within adjacent discs during flexion-extension.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
12 01 2021
12 01 2021
Historique:
received:
18
12
2019
accepted:
10
11
2020
entrez:
13
1
2021
pubmed:
14
1
2021
medline:
11
8
2021
Statut:
epublish
Résumé
The biomechanical function of the intervertebral disc (IVD) is a critical indicator of tissue health and pathology. The mechanical responses (displacements, strain) of the IVD to physiologic movement can be spatially complex and depend on tissue architecture, consisting of distinct compositional regions and integrity; however, IVD biomechanics are predominately uncharacterized in vivo. Here, we measured voxel-level displacement and strain patterns in adjacent IVDs in vivo by coupling magnetic resonance imaging (MRI) with cyclic motion of the cervical spine. Across adjacent disc segments, cervical flexion-extension of 10° resulted in first principal and maximum shear strains approaching 10%. Intratissue spatial analysis of the cervical IVDs, not possible with conventional techniques, revealed elevated maximum shear strains located in the posterior disc (nucleus pulposus) regions. IVD structure, based on relaxometric patterns of T
Identifiants
pubmed: 33436667
doi: 10.1038/s41598-020-77577-y
pii: 10.1038/s41598-020-77577-y
pmc: PMC7804136
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
729Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR063712
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008497
Pays : United States
Organisme : NIAMS NIH HHS
ID : R21 AR066665
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM065103
Pays : United States
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