The amphibian peptide Yodha is virucidal for Zika and dengue viruses.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
12 01 2021
12 01 2021
Historique:
received:
01
11
2019
accepted:
24
12
2020
entrez:
13
1
2021
pubmed:
14
1
2021
medline:
10
8
2021
Statut:
epublish
Résumé
Zika virus (ZIKV) has emerged as a serious health threat in the Americas and the Caribbean. ZIKV is transmitted by the bite of an infected mosquito, sexual contact, and blood transfusion. ZIKV can also be transmitted to the developing fetus in utero, in some cases resulting in spontaneous abortion, fetal brain abnormalities, and microcephaly. In adults, ZIKV infection has been correlated with Guillain-Barre syndrome. Despite the public health threat posed by ZIKV, neither a vaccine nor antiviral drugs for use in humans are currently available. We have identified an amphibian host defense peptide, Yodha, which has potent virucidal activity against ZIKV. It acts directly on the virus and destroys Zika virus particles within 5 min of exposure. The Yodha peptide was effective against the Asian, African, and South American Zika virus strains and has the potential to be developed as an antiviral therapeutic in the fight against Zika virus. The peptide was also effective against all four dengue virus serotypes. Thus, Yodha peptide could potentially be developed as a pan-therapeutic for Zika and dengue viruses.
Identifiants
pubmed: 33436917
doi: 10.1038/s41598-020-80596-4
pii: 10.1038/s41598-020-80596-4
pmc: PMC7804942
doi:
Substances chimiques
Antiviral Agents
0
Peptide Fragments
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
602Subventions
Organisme : NIAID NIH HHS
ID : U19 AI083019
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008169
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI100110
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR025679
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI110516
Pays : United States
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