Transcriptomic similarities and differences in host response between SARS-CoV-2 and other viral infections.
Immunology: Bioinformatics
Molecular Biology
Transcriptomics
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
22 Jan 2021
22 Jan 2021
Historique:
received:
10
07
2020
revised:
11
11
2020
accepted:
11
12
2020
entrez:
13
1
2021
pubmed:
14
1
2021
medline:
14
1
2021
Statut:
epublish
Résumé
The pandemic 2019 novel coronavirus disease (COVID-19) shares certain clinical characteristics with other acute viral infections. We studied the whole-blood transcriptomic host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using RNAseq from 24 healthy controls and 62 prospectively enrolled patients with COVID-19. We then compared these data to non-COVID-19 viral infections, curated from 23 independent studies profiling 1,855 blood samples covering six viruses (influenza, respiratory syncytial virus (RSV), human rhinovirus (HRV), severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1), Ebola, dengue). We show gene expression changes in COVID-19 versus non-COVID-19 viral infections are highly correlated (r = 0.74, p < 0.001). However, we also found 416 genes specific to COVID-19. Inspection of top genes revealed dynamic immune evasion and counter host responses specific to COVID-19. Statistical deconvolution of cell proportions maps many cell type proportions concordantly shifting. Discordantly increased in COVID-19 were CD56
Identifiants
pubmed: 33437935
doi: 10.1016/j.isci.2020.101947
pii: S2589-0042(20)31144-5
pmc: PMC7786129
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101947Informations de copyright
© 2020 The Authors.
Déclaration de conflit d'intérêts
S.A.T., Y.D.H., Y.H., S.S., R.P., D.R., M.R., S.C., and T.E.S. are employees of and stockholders in Inflammatix, Inc. P.K. reports being a shareholder and a consultant to Inflammatix, Inc. E.J.G.B. reports receiving honoraria from 10.13039/100006483AbbVie 10.13039/100011408USA, Abbott CH, InflaRx GmbH, MSD Greece, XBiotech Inc., and 10.13039/501100006546Angelini Italy; independent educational grants from 10.13039/100006483AbbVie, Abbott, 10.13039/501100006044Astellas Pharma Europe, AxisShield, bioMérieux Inc, InflaRx GmbH, and XBiotech Inc; and funding from the FrameWork 7 program HemoSpec (granted to the National and Kapodistrian University of Athens), the 10.13039/501100007601Horizon 2020 Marie-Curie Project European Sepsis Academy (granted to the National and Kapodistrian University of Athens), and the 10.13039/501100007601Horizon 2020 European Grant ImmunoSep (granted to the Hellenic Institute for the Study of Sepsis). The other authors declare no competing interests.
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