Emerging role of VCP/p97 in cardiovascular diseases: novel insights and therapeutic opportunities.
VCP/p97
cardiovascular diseases
iNOS
mitochondria
Journal
Biochemical Society transactions
ISSN: 1470-8752
Titre abrégé: Biochem Soc Trans
Pays: England
ID NLM: 7506897
Informations de publication
Date de publication:
26 02 2021
26 02 2021
Historique:
received:
12
10
2020
revised:
22
11
2020
accepted:
25
11
2020
pubmed:
14
1
2021
medline:
27
1
2022
entrez:
13
1
2021
Statut:
ppublish
Résumé
Valosin-containing protein (VCP/p97) is a member of the conserved type II AAA+ (ATPases associated with diverse cellular activities) family of proteins with multiple biological functions, especially in protein homeostasis. Mutations in VCP/p97 are reportedly related to unique autosomal dominant diseases, which may worsen cardiac function. Although the structure of VCP/p97 has been clearly characterized, with reports of high abundance in the heart, research focusing on the molecular mechanisms underpinning the roles of VCP/p97 in the cardiovascular system has been recently undertaken over the past decades. Recent studies have shown that VCP/p97 deficiency affects myocardial fibers and induces heart failure, while overexpression of VCP/p97 eliminates ischemia/reperfusion injury and relieves pathological cardiac hypertrophy caused by cardiac pressure overload, which is related to changes in the mitochondria and calcium overload. However, certain studies have drawn opposing conclusions, including the mitigation of ischemia/reperfusion injury via inhibition of VCP/p97 ATPase activity. Nevertheless, these emerging studies shed light on the role of VCP/p97 and its therapeutic potential in cardiovascular diseases. In other words, VCP/p97 may be involved in the development of cardiovascular disease, and is anticipated to be a new therapeutic target. This review summarizes current findings regarding VCP/p97 in the cardiovascular system for the first time, and discusses the role of VCP/p97 in cardiovascular disease.
Identifiants
pubmed: 33439255
pii: 227567
doi: 10.1042/BST20200981
pmc: PMC7925001
doi:
Substances chimiques
VCP protein, human
EC 3.6.4.6
Valosin Containing Protein
EC 3.6.4.6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
485-494Informations de copyright
© 2021 The Author(s).
Références
Sci Rep. 2017 Apr 20;7:46324
pubmed: 28425440
Mol Cell Proteomics. 2016 Sep;15(9):2970-86
pubmed: 27406709
PLoS One. 2012;7(12):e50490
pubmed: 23226521
Nat Struct Mol Biol. 2018 Jul;25(7):616-622
pubmed: 29967539
Curr Opin Cell Biol. 2018 Aug;53:22-28
pubmed: 29719269
J Neurosci. 2010 Jun 2;30(22):7729-39
pubmed: 20519548
Biochem Biophys Res Commun. 2009 May 1;382(2):303-8
pubmed: 19275885
Genetics. 1982 Apr;100(4):547-63
pubmed: 6749598
Toxicol Appl Pharmacol. 2008 May 1;228(3):351-63
pubmed: 18261755
J Biol Chem. 2016 Jul 1;291(27):14373-84
pubmed: 27226613
Genes Cells. 2013 Dec;18(12):1131-43
pubmed: 24215292
Cardiovasc Res. 2016 Jan 1;109(1):103-14
pubmed: 26598511
J Cell Sci. 2014 May 1;127(Pt 9):1980-91
pubmed: 24569878
Nat Med. 2011 Nov 07;17(11):1391-401
pubmed: 22064429
Biochim Biophys Acta. 2008 Dec;1782(12):744-8
pubmed: 18845250
Circ J. 2011;75(5):1061-2
pubmed: 21467665
Circulation. 2016 Jun 21;133(25):2610-7
pubmed: 27324356
JACC Basic Transl Sci. 2019 Oct 28;4(6):701-714
pubmed: 31709319
F1000Res. 2017 Aug 3;6:1318
pubmed: 28815021
Cardiovasc Res. 2013 Sep 1;99(4):685-93
pubmed: 23737493
Curr Opin Cardiol. 2017 Nov;32(6):784-790
pubmed: 28902715
J Biol Chem. 2017 May 26;292(21):8907-8917
pubmed: 28360103
Int J Mol Sci. 2020 May 28;21(11):
pubmed: 32481679
Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):552-559
pubmed: 27913212
Oxid Med Cell Longev. 2018 Oct 28;2018:8364848
pubmed: 30510628
Hum Gene Ther Methods. 2015 Feb;26(1):13-24
pubmed: 25545721
Int J Biochem Cell Biol. 2011 Apr;43(4):613-21
pubmed: 21199683
Biochem Biophys Res Commun. 2013 Apr 5;433(2):237-42
pubmed: 23500464
Neuron. 2013 Apr 10;78(1):65-80
pubmed: 23498974
J Biol Chem. 2006 May 19;281(20):14307-13
pubmed: 16551632
Sci Rep. 2018 Aug 17;8(1):12415
pubmed: 30120381
EMBO J. 2017 Jan 17;36(2):135-150
pubmed: 27753622
Front Mol Biosci. 2017 Apr 13;4:21
pubmed: 28451587
Nat Genet. 2004 Apr;36(4):377-81
pubmed: 15034582
J Clin Invest. 2010 Aug;120(8):2805-16
pubmed: 20644257
Nature. 1987 Feb 5-11;325(6104):542-5
pubmed: 3468358
J Mol Cell Cardiol. 2016 Aug;97:245-62
pubmed: 27262674
J Biol Chem. 2004 Oct 29;279(44):45676-84
pubmed: 15331598
J Cardiovasc Dev Dis. 2016 Jun;3(2):
pubmed: 27500162
Circ Res. 2014 Jan 17;114(2):368-78
pubmed: 24436432
J Biol Chem. 2019 May 31;294(22):8918-8929
pubmed: 31006653
J Mol Cell Cardiol. 2001 Nov;33(11):1897-918
pubmed: 11708836
Free Radic Biol Med. 2017 May;106:345-354
pubmed: 28216385
J Mol Cell Cardiol. 2016 Feb;91:11-22
pubmed: 26718721
Hum Mol Genet. 2006 Jan 15;15(2):189-99
pubmed: 16321991
J Clin Invest. 2013 Jan;123(1):92-100
pubmed: 23281415
Neuromuscul Disord. 2018 Jun;28(6):491-501
pubmed: 29754758
Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1705-14
pubmed: 25775548
Nat Commun. 2016 Mar 09;7:10955
pubmed: 26956930
Nat Commun. 2016 Oct 20;7:13047
pubmed: 27762274
Eur J Cell Biol. 2016 Jun-Jul;95(6-7):195-207
pubmed: 27132113
Aging (Albany NY). 2017 Dec 26;9(12):2469-2470
pubmed: 29283888
Sci Rep. 2016 Jan 28;6:20037
pubmed: 26818443
Arch Toxicol. 2015 Sep;89(9):1401-38
pubmed: 25708889
Med Sci Monit Basic Res. 2016 Jul 23;22:75-9
pubmed: 27450399
Biochem Biophys Res Commun. 1990 Dec 31;173(3):872-7
pubmed: 2148477
Eur Heart J. 2012 Apr;33(7):829-37, 837a-837d
pubmed: 21890489
Front Mol Biosci. 2017 May 29;4:33
pubmed: 28611990
J Biol Chem. 2005 Sep 9;280(36):31870-81
pubmed: 16027165
Mol Cell. 2018 Jan 18;69(2):182-194
pubmed: 29153394
Curr Mol Med. 2017;17(9):608-618
pubmed: 29521227
Hum Mol Genet. 2019 Oct 15;28(20):3486-3497
pubmed: 31577344
JAMA Cardiol. 2016 Aug 1;1(5):599-600
pubmed: 27438674
J Biol Chem. 2012 Mar 9;287(11):8561-70
pubmed: 22270372
J Neurosci. 2019 Sep 4;39(36):7074-7085
pubmed: 31300519
Ageing Res Rev. 2017 Nov;40:1-10
pubmed: 28757291
Mitochondrion. 2015 May;22:1-8
pubmed: 25724235
Toxicol Sci. 2019 Jul 31;:
pubmed: 31368507
Circ Res. 2018 Feb 2;122(3):489-505
pubmed: 29420210
Aging Cell. 2017 Oct;16(5):1168-1179
pubmed: 28799247
Methods Mol Biol. 2018;1732:321-342
pubmed: 29480485
Exp Cell Res. 2014 Nov 15;329(1):9-17
pubmed: 25169698
Cell Res. 2012 Feb;22(2):346-59
pubmed: 21556036