Multinational Survey of Current Practice from Imaging to Treatment of Atherosclerotic Carotid Stenosis.


Journal

Cerebrovascular diseases (Basel, Switzerland)
ISSN: 1421-9786
Titre abrégé: Cerebrovasc Dis
Pays: Switzerland
ID NLM: 9100851

Informations de publication

Date de publication:
2021
Historique:
received: 21 07 2020
accepted: 07 10 2020
pubmed: 14 1 2021
medline: 6 8 2021
entrez: 13 1 2021
Statut: ppublish

Résumé

In the last 20-30 years, there have been many advances in imaging and therapeutic strategies for symptomatic and asymptomatic individuals with carotid artery stenosis. Our aim was to examine contemporary multinational practice standards. Departmental Review Board approval for this study was obtained, and 3 authors prepared the 44 multiple choice survey questions. Endorsement was obtained by the European Society of Neuroradiology, American Society of Functional Neuroradiology, and African Academy of Neurology. A link to the online questionnaire was sent to their respective members and members of the Faculty Advocating Collaborative and Thoughtful Carotid Artery Treatments (FACTCATS). The questionnaire was open from May 16 to July 16, 2019. The responses from 223 respondents from 46 countries were included in the analyses including 65.9% from academic university hospitals. Neuroradiologists/radiologists comprised 68.2% of respondents, followed by neurologists (15%) and vascular surgeons (12.9%). In symptomatic patients, half (50.4%) the respondents answered that the first exam they used to evaluate carotid bifurcation was ultrasound, followed by computed tomography angiography (CTA, 41.6%) and then magnetic resonance imaging (MRI 8%). In asymptomatic patients, the first exam used to evaluate carotid bifurcation was ultrasound in 88.8% of respondents, CTA in 7%, and MRA in 4.2%. The percent stenosis upon which carotid endarterectomy or stenting was recommended was reduced in the presence of imaging evidence of "vulnerable plaque features" by 66.7% respondents for symptomatic patients and 34.2% for asymptomatic patients with a smaller subset of respondents even offering procedural intervention to patients with <50% symptomatic or asymptomatic stenosis. We found heterogeneity in current practices of carotid stenosis imaging and management in this worldwide survey with many respondents including vulnerable plaque imaging into their decision analysis despite the lack of proven benefit from clinical trials. This study highlights the need for new clinical trials using vulnerable plaque imaging to select high-risk patients despite maximal medical therapy who may benefit from procedural intervention.

Sections du résumé

BACKGROUND
In the last 20-30 years, there have been many advances in imaging and therapeutic strategies for symptomatic and asymptomatic individuals with carotid artery stenosis. Our aim was to examine contemporary multinational practice standards.
METHODS
Departmental Review Board approval for this study was obtained, and 3 authors prepared the 44 multiple choice survey questions. Endorsement was obtained by the European Society of Neuroradiology, American Society of Functional Neuroradiology, and African Academy of Neurology. A link to the online questionnaire was sent to their respective members and members of the Faculty Advocating Collaborative and Thoughtful Carotid Artery Treatments (FACTCATS). The questionnaire was open from May 16 to July 16, 2019.
RESULTS
The responses from 223 respondents from 46 countries were included in the analyses including 65.9% from academic university hospitals. Neuroradiologists/radiologists comprised 68.2% of respondents, followed by neurologists (15%) and vascular surgeons (12.9%). In symptomatic patients, half (50.4%) the respondents answered that the first exam they used to evaluate carotid bifurcation was ultrasound, followed by computed tomography angiography (CTA, 41.6%) and then magnetic resonance imaging (MRI 8%). In asymptomatic patients, the first exam used to evaluate carotid bifurcation was ultrasound in 88.8% of respondents, CTA in 7%, and MRA in 4.2%. The percent stenosis upon which carotid endarterectomy or stenting was recommended was reduced in the presence of imaging evidence of "vulnerable plaque features" by 66.7% respondents for symptomatic patients and 34.2% for asymptomatic patients with a smaller subset of respondents even offering procedural intervention to patients with <50% symptomatic or asymptomatic stenosis.
CONCLUSIONS
We found heterogeneity in current practices of carotid stenosis imaging and management in this worldwide survey with many respondents including vulnerable plaque imaging into their decision analysis despite the lack of proven benefit from clinical trials. This study highlights the need for new clinical trials using vulnerable plaque imaging to select high-risk patients despite maximal medical therapy who may benefit from procedural intervention.

Identifiants

pubmed: 33440369
pii: 000512181
doi: 10.1159/000512181
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

108-120

Subventions

Organisme : Department of Health
ID : 01/37/03
Pays : United Kingdom
Organisme : Chief Scientist Office
ID : TCS/17/08
Pays : United Kingdom

Informations de copyright

© 2021 S. Karger AG, Basel.

Auteurs

Luca Saba (L)

Department of Radiology, University of Cagliari, Cagliari, Italy, lucasaba@tiscali.it.

Mahmoud Mossa-Basha (M)

Department of Neuroradiology, University of Washington Medical Center, Seattle, Washington, USA.

Anne Abbott (A)

Central Clinical School, Monash University, Melbourne, Victoria, Australia.

Giuseppe Lanzino (G)

Department of Neurologic Surgery, Mayo Clinic, Rochester, Michigan, USA.

Joanna M Wardlaw (JM)

Neuroimaging Sciences, Centre for Clinical Brain Sciences, Edinburgh Imaging and UK Dementia Research Institute, University of Edinburgh, Edinburgh, United Kingdom.

Thomas S Hatsukami (TS)

Department of Surgery, University of Washington, Seattle, Washington, USA.

Giulio Micheletti (G)

Department of Radiology, University of Cagliari, Cagliari, Italy.

Antonella Balestrieri (A)

Department of Radiology, University of Cagliari, Cagliari, Italy.

Ulf Hedin (U)

Department of Vascular Surgery and Molecular Medicine and Surgery, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden.

Alan R Moody (AR)

Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada.

Max Wintermark (M)

Neuroradiology Division, Department of Radiology, Stanford University, Stanford, California, USA.

J Kevin DeMarco (JK)

Department of Radiology, Walter Reed National Military Medical Center and Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.

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Classifications MeSH