Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond.
flavonoids
iron ions
metallocomplexes
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
11 Jan 2021
11 Jan 2021
Historique:
received:
04
12
2020
revised:
30
12
2020
accepted:
02
01
2021
entrez:
14
1
2021
pubmed:
15
1
2021
medline:
7
4
2021
Statut:
epublish
Résumé
Flavonoids are common plant natural products able to suppress ROS-related damage and alleviate oxidative stress. One of key mechanisms, involved in this phenomenon is chelation of transition metal ions. From a physiological perspective, iron is the most significant transition metal, because of its abundance in living organisms and ubiquitous involvement in redox processes. The chemical, pharmaceutical, and biological properties of flavonoids can be significantly affected by their interaction with transition metal ions, mainly iron. In this review, we explain the interaction of various flavonoid structures with Fe(II) and Fe(III) ions and critically discuss the influence of chelated ions on the flavonoid biochemical properties. In addition, specific biological effects of their iron metallocomplexes, such as the inhibition of iron-containing enzymes, have been included in this review.
Identifiants
pubmed: 33440733
pii: ijms22020646
doi: 10.3390/ijms22020646
pmc: PMC7827006
pii:
doi:
Substances chimiques
Antioxidants
0
Chelating Agents
0
Coordination Complexes
0
Flavonoids
0
Ions
0
Heme
42VZT0U6YR
Iron
E1UOL152H7
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Education, Youth and Sports of the Czech Republic
ID : BIOCEV-FAR
Organisme : Ministry of Education, Youth and Sports of the Czech Republic
ID : LQ1604
Organisme : Ministry of Education, Youth and Sports of the Czech Republic
ID : LM2018133
Organisme : Charles University in Prague
ID : SVV260521
Organisme : Charles University in Prague
ID : UNCE 204064
Organisme : Charles University in Prague
ID : Progress Q26/LF1
Organisme : Charles University in Prague
ID : Q27/LF1
Organisme : Ministry of Health of the Czech Republic
ID : RVO-VFN-64165/2012
Organisme : Ministry of Industry and Trade of Czech Republic
ID : FV20572
Organisme : Technology Agency of the Czech Republic
ID : TN01000013
Organisme : Technology Agency of the Czech Republic
ID : FW02020128
Organisme : Operational Programme Research, Development and Education
ID : CZ.02.1.01/0.0/0.0/16_019/0000785
Références
Adv Nutr. 2012 Jan;3(1):39-46
pubmed: 22332099
Biofizika. 2014 May-Jun;59(3):432-8
pubmed: 25715583
J Inorg Biochem. 2002 Nov 11;92(2):105-11
pubmed: 12459155
Biochem Pharmacol. 2001 Jul 1;62(1):111-8
pubmed: 11377402
J Agric Food Chem. 2002 Jul 17;50(15):4317-22
pubmed: 12105964
Inflammation. 2015 Apr;38(2):858-70
pubmed: 25139581
Mol Nutr Food Res. 2017 Apr;61(4):
pubmed: 27943649
Free Radic Res. 2002 Nov;36(11):1199-208
pubmed: 12592672
J Clin Invest. 1981 Nov;68(5):1243-52
pubmed: 6271809
J Med Chem. 2018 Dec 13;61(23):10403-10411
pubmed: 29986141
J Agric Food Chem. 2003 Feb 26;51(5):1173-6
pubmed: 12590452
Biochim Biophys Acta. 2012 Mar;1818(3):695-702
pubmed: 22179037
Mol Biosyst. 2010 Feb;6(2):357-64
pubmed: 20094655
Chem Rev. 2014 Apr 9;114(7):3919-62
pubmed: 24400737
Bioorg Med Chem. 2007 Dec 1;15(23):7408-25
pubmed: 17869117
AAPS PharmSciTech. 2009;10(3):943-50
pubmed: 19629709
Curr Drug Targets. 2018;19(14):1710-1720
pubmed: 29577854
Oxid Med Cell Longev. 2019 Nov 30;2019:6713194
pubmed: 31885810
PLoS One. 2014 Jul 15;9(7):e102460
pubmed: 25025898
Toxicol Sci. 2004 Nov;82(1):70-9
pubmed: 15319488
J Am Coll Nutr. 2010 Feb;29(1):31-40
pubmed: 20595643
Eur J Pharmacol. 2010 Dec 15;649(1-3):301-13
pubmed: 20868659
J Nat Prod. 1987 May-Jun;50(3):427-33
pubmed: 2959755
Biochem Biophys Res Commun. 1973 Apr 2;51(3):781-8
pubmed: 4704060
Lipids Health Dis. 2018 Jun 23;17(1):146
pubmed: 29935544
Geriatr Gerontol Int. 2014 Apr;14(2):430-9
pubmed: 23879665
Int J Nanomedicine. 2014;9:1-15
pubmed: 24363556
J Inorg Biochem. 2009 Mar;103(3):326-32
pubmed: 19108897
Redox Biol. 2015 Dec;6:297-310
pubmed: 26298204
AAPS PharmSciTech. 2019 Sep 16;20(8):314
pubmed: 31529175
Molecules. 2018 May 29;23(6):
pubmed: 29843466
Mol Pharmacol. 2008 Jul;74(1):70-81
pubmed: 18426858
J Steroid Biochem Mol Biol. 1990 Oct;37(2):257-60
pubmed: 2268557
Foods. 2020 May 26;9(6):
pubmed: 32466434
Gen Physiol Biophys. 2010 Jun;29(2):134-43
pubmed: 20577025
J Inorg Biochem. 2010 Oct;104(10):1091-8
pubmed: 20656356
Mol Cell Endocrinol. 2009 Mar 25;301(1-2):235-44
pubmed: 19000737
Int J Biol Macromol. 2013 Jul;58:148-53
pubmed: 23567286
J Phys Chem B. 2015 Jan 8;119(1):83-95
pubmed: 25486072
Int J Cancer. 2006 Apr 15;118(8):1915-21
pubmed: 16287071
Biol Trace Elem Res. 2020 Jun;195(2):353-365
pubmed: 31473898
J Inorg Biochem. 2012 Feb;107(1):34-9
pubmed: 22172500
J Appl Physiol (1985). 2019 Jan 1;126(1):246-254
pubmed: 30496705
Food Chem. 2012 Dec 15;135(4):2584-92
pubmed: 22980846
Am J Clin Nutr. 2005 Jan;81(1 Suppl):230S-242S
pubmed: 15640486
Int J Food Sci Nutr. 2015;66(7):830-6
pubmed: 26471075
Int J Mol Sci. 2017 Dec 22;19(1):
pubmed: 29271940
Phytother Res. 2004 Feb;18(2):123-7
pubmed: 15022163
Nutr Metab Cardiovasc Dis. 2014 Apr;24(4):416-22
pubmed: 24462367
Nutrients. 2015 Apr 02;7(4):2324-44
pubmed: 25849944
J Microbiol Biotechnol. 2020 Jan 28;30(1):11-20
pubmed: 31752056
Biochem Biophys Res Commun. 2013 Feb 22;431(4):680-5
pubmed: 23357424
Free Radic Biol Med. 2008 Feb 15;44(4):657-70
pubmed: 18061585
Nutr Res. 2008 Sep;28(9):620-8
pubmed: 19083468
Arch Biochem Biophys. 2007 May 15;461(2):176-85
pubmed: 17391639
Int J Biol Macromol. 2017 Nov;104(Pt A):929-935
pubmed: 28663152
Food Chem. 2016 Oct 1;208:26-34
pubmed: 27132820
Colloids Surf B Biointerfaces. 2014 Nov 1;123:331-8
pubmed: 25282100
J Inorg Biochem. 2011 May;105(5):693-701
pubmed: 21450273
Biometals. 2000 Mar;13(1):77-83
pubmed: 10831228
Bone. 2008 Jul;43(1):162-168
pubmed: 18430624
Free Radic Biol Med. 2011 Apr 15;50(8):934-44
pubmed: 21238582
Am J Physiol. 1966 Aug;211(2):429-36
pubmed: 4224148
Biosci Biotechnol Biochem. 1999 Oct;63(10):1787-90
pubmed: 10671036
Science. 1984 Sep 7;225(4666):1032-4
pubmed: 6474163
Appl Biochem Biotechnol. 2015 Aug;176(7):1904-13
pubmed: 26047928
J Invest Dermatol. 1996 Jan;106(1):11-6
pubmed: 8592059
Chem Res Toxicol. 2008 Aug;21(8):1600-9
pubmed: 18620432
Environ Toxicol. 2018 Oct;33(10):1069-1077
pubmed: 30098279
Biosci Biotechnol Biochem. 2017 May;81(5):882-890
pubmed: 28388357
Biomed Pharmacother. 2017 Apr;88:1122-1144
pubmed: 28208574
J Agric Food Chem. 2003 Sep 24;51(20):6014-20
pubmed: 13129310
J Agric Food Chem. 2006 Aug 23;54(17):6343-51
pubmed: 16910729
Anal Chem. 2000 Dec 15;72(24):5898-906
pubmed: 11140755
Alcohol Clin Exp Res. 2001 Mar;25(3):434-43
pubmed: 11290856
Arch Biochem Biophys. 2001 Jan 1;385(1):129-37
pubmed: 11361008
Food Chem. 2017 Apr 15;221:1088-1095
pubmed: 27979063
Bioorg Med Chem. 2009 Jan 15;17(2):614-20
pubmed: 19097913
Dalton Trans. 2007 Nov 21;(43):4951-61
pubmed: 17992280
Int J Mol Sci. 2014 Oct 24;15(11):19369-88
pubmed: 25347275
Mol Nutr Food Res. 2017 Mar;61(3):
pubmed: 27794191
Physiology (Bethesda). 2016 Jul;31(4):258-69
pubmed: 27252161
Bone. 2017 Aug;101:134-144
pubmed: 28455215
Environ Health Perspect. 1998 Feb;106(2):85-92
pubmed: 9435150
J Inorg Biochem. 2020 Jul;208:111095
pubmed: 32442763
J Fluoresc. 2016 Nov;26(6):2023-2031
pubmed: 27481501
Biosci Biotechnol Biochem. 2003 Jun;67(6):1215-22
pubmed: 12843645
Molecules. 2020 Sep 21;25(18):
pubmed: 32967119
J Biol Chem. 1993 Feb 25;268(6):4069-77
pubmed: 8382689
Biosci Biotechnol Biochem. 2001 Jan;65(1):126-32
pubmed: 11272815
Arch Biochem Biophys. 2004 Aug 15;428(2):204-8
pubmed: 15246878
Free Radic Biol Med. 2013 Dec;65:1174-1194
pubmed: 24036104
Environ Health Prev Med. 2002 May;7(2):64-73
pubmed: 21432266
J Biol Chem. 2008 Apr 4;283(14):9424-34
pubmed: 18199750
Oncogene. 2020 Mar;39(10):2187-2201
pubmed: 31822799
Free Radic Res. 2007 Mar;41(3):342-56
pubmed: 17364964
J Nutr Sci. 2016 Dec 29;5:e47
pubmed: 28620474
Biochimie. 2018 Aug;151:107-114
pubmed: 29857184
Biochem Pharmacol. 1989 Sep 1;38(17):2859-65
pubmed: 2476132
Clin Nutr ESPEN. 2017 Aug;20:68-77
pubmed: 29072172
J Mol Model. 2010 May;16(5):1039-45
pubmed: 19911203
Molecules. 2018 Feb 23;23(2):
pubmed: 29473839
PLoS One. 2016 Oct 27;11(10):e0165575
pubmed: 27788249
Nutrients. 2018 Jun 02;10(6):
pubmed: 29865234
J Complement Integr Med. 2015 Dec;12(4):277-82
pubmed: 26259232
PLoS One. 2018 Jul 11;13(7):e0200449
pubmed: 29995924
Nat Prod Rep. 2009 Jul;26(7):884-915
pubmed: 19554240
Biomolecules. 2018 Nov 15;8(4):
pubmed: 30445784
Antioxidants (Basel). 2020 Dec 17;9(12):
pubmed: 33348578
DNA Repair (Amst). 2020 Jul - Aug;91-92:102871
pubmed: 32502755
J Agric Food Chem. 2008 May 28;56(10):3609-15
pubmed: 18454540
Molecules. 2019 Mar 21;24(6):
pubmed: 30901869
Int J Cancer. 2007 Nov 15;121(10):2225-32
pubmed: 17471564
Breast Cancer Res Treat. 1986;7 Suppl:S23-35
pubmed: 3527304
Cancers (Basel). 2020 Dec 17;12(12):
pubmed: 33348579
Biotechnol Adv. 2020 Nov 1;43:107600
pubmed: 32693016
Free Radic Biol Med. 2005 Dec 15;39(12):1591-600
pubmed: 16298684
Plants (Basel). 2018 Apr 03;7(2):
pubmed: 29614017
J Biol Chem. 1982 Apr 10;257(7):3606-17
pubmed: 6277939
Ann N Y Acad Sci. 2017 Jun;1398(1):120-129
pubmed: 28436044
J Mol Biol. 1985 Sep 5;185(1):21-37
pubmed: 4046038
J Biomol Struct Dyn. 2020 Dec 11;:1-9
pubmed: 33306006
Phytother Res. 2009 Jan;23(1):136-9
pubmed: 18803248
Mol Pharmacol. 2007 Jun;71(6):1676-84
pubmed: 17377063
Fitoterapia. 2011 Jun;82(4):513-23
pubmed: 21277359
Eur J Pharmacol. 2021 Feb 15;893:173808
pubmed: 33345858
Parkinsonism Relat Disord. 2011 Jul;17(6):446-50
pubmed: 21458354
Rev Endocr Metab Disord. 2020 Dec;21(4):631-643
pubmed: 32125563
J Agric Food Chem. 2008 Nov 12;56(21):10092-8
pubmed: 18831560
Biochemistry (Mosc). 2003 May;68(5):514-9
pubmed: 12882632
J Nutr. 2003 Nov;133(11 Suppl 1):3773S-3777S
pubmed: 14608113