E2F1 regulates testicular descent and controls spermatogenesis by influencing WNT4 signaling.

Aging / pathology Animals Animals, Newborn Blood-Testis Barrier / pathology Cell Cycle / genetics Cryptorchidism / genetics E2F1 Transcription Factor / deficiency Fertility Gene Expression Regulation Male Mice, Inbred C57BL Models, Biological Signal Transduction Spermatogenesis Spermatozoa / metabolism Testis / metabolism Wnt4 Protein / metabolism
Copy number variations Cryptorchidism E2f1 Infertility Testicular cancer Wnt4

Journal

Development (Cambridge, England)
ISSN: 1477-9129
Titre abrégé: Development
Pays: England
ID NLM: 8701744

Informations de publication

Date de publication:
13 01 2021
Historique:
received: 02 04 2020
accepted: 26 11 2020
entrez: 14 1 2021
pubmed: 15 1 2021
medline: 23 4 2021
Statut: epublish

Résumé

Cryptorchidism is the most common urologic birth defect in men and is a predisposing factor of male infertility and testicular cancer, yet the etiology remains largely unknown.

Identifiants

DOI: 10.1242/dev.191189 PMID: 33441379 PMC: PMC7823160
pubmed: 33441379
pii: 148/1/dev191189
doi: 10.1242/dev.191189
pmc: PMC7823160
pii:
doi:

Substances chimiques

E2F1 Transcription Factor 0
Wnt4 Protein 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NICHD NIH HHS
ID : P01 HD087157
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD095341
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK078121
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD100549
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD100985
Pays : United States
Organisme : NIDDK NIH HHS
ID : K12 DK083014
Pays : United States

Informations de copyright

© 2021. Published by The Company of Biologists Ltd.

Déclaration de conflit d'intérêts

Competing interestsC.J.J., A.S., N.W., J.C.B. and C.H.C. declared no competing interests. D.J.L. serves on the Scientific Advisory Board of Celmatix (no financial compensation) and Fellow (stock options; not executed), is Secretary-Treasurer of the American Board of Bioanalysts (honorarium), and is on the World Health Organization Editorial Board for WHO Laboratory Manual for the Examination and Processing of Human Semen, sixth edition (travel costs only).

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Auteurs

Carolina J Jorgez (CJ)

Scott Department of Urology, Baylor College of Medicine, Houston, TX 77030, USA cj129804@bcm.edu dlamb@med.cornell.edu.
Department of Surgery, Texas Children's Hospital, Houston, TX 77030, USA.
Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
ORCID: 0000-0001-9203-6331

Abhishek Seth (A)

Scott Department of Urology, Baylor College of Medicine, Houston, TX 77030, USA.
Department of Surgery, Texas Children's Hospital, Houston, TX 77030, USA.
Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

Nathan Wilken (N)

Scott Department of Urology, Baylor College of Medicine, Houston, TX 77030, USA.
Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

Juan C Bournat (JC)

Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

Ching H Chen (CH)

Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

Dolores J Lamb (DJ)

Scott Department of Urology, Baylor College of Medicine, Houston, TX 77030, USA cj129804@bcm.edu dlamb@med.cornell.edu.
Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Brady Urology Department, Center for Reproductive Genomics and Englander Institute for Precision Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
ORCID: 0000-0002-4389-5065

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › E2F1 regulates testicular descent and controls...
questionsmedicales.fr › Eucaryotes › Animaux › E2F1 regulates testicular descent and controls...
questionsmedicales.fr › Eucaryotes › Animaux › Groupes animaux › Animaux nouveau-nés › E2F1 regulates testicular descent and controls...
questionsmedicales.fr › Système cardiovasculaire › Barrière hématotesticulaire › E2F1 regulates testicular descent and controls...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Cycle cellulaire › E2F1 regulates testicular descent and controls...
questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Maladies testiculaires › Cryptorchidie › E2F1 regulates testicular descent and controls...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription E2F › Facteur de transcription E2F1 › E2F1 regulates testicular descent and controls...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Fécondité › E2F1 regulates testicular descent and controls...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › E2F1 regulates testicular descent and controls...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › E2F1 regulates testicular descent and controls...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › E2F1 regulates testicular descent and controls...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › E2F1 regulates testicular descent and controls...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Gamétogenèse › Spermatogenèse › E2F1 regulates testicular descent and controls...
questionsmedicales.fr › Cellules › Cellules germinales › Spermatozoïdes › E2F1 regulates testicular descent and controls...
questionsmedicales.fr › Système endocrine › Glandes endocrines › Gonades › Testicule › E2F1 regulates testicular descent and controls...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de type Wingless › Protéine Wnt4 › E2F1 regulates testicular descent and controls...