Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption.


Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
13 01 2021
Historique:
received: 22 07 2020
revised: 04 10 2020
accepted: 30 11 2020
entrez: 14 1 2021
pubmed: 15 1 2021
medline: 13 7 2021
Statut: ppublish

Résumé

Type 1 interferons (IFN-I) are potent innate antiviral effectors that constrain HIV-1 transmission. However, harnessing these cytokines for HIV-1 cure strategies has been hampered by an incomplete understanding of their antiviral activities at later stages of infection. Here, we characterized the IFN-I sensitivity of 500 clonally derived HIV-1 isolates from the plasma and CD4

Identifiants

pubmed: 33441429
pii: 13/576/eabd8179
doi: 10.1126/scitranslmed.abd8179
pmc: PMC7923595
mid: NIHMS1667384
pii:
doi:

Substances chimiques

Antiviral Agents 0
Interferon Type I 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAID NIH HHS
ID : UM1 AI126620
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007632
Pays : United States
Organisme : Medical Research Council
ID : MR/K012037/1
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : UM1 AI126619
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI114266
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI162646
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI131251
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI118549
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI129825
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI144371
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI100663
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI111789
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI045008
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI065279
Pays : United States
Organisme : NIAID NIH HHS
ID : R33 AI133696
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI160607
Pays : United States

Informations de copyright

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

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Auteurs

Marcos V P Gondim (MVP)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Scott Sherrill-Mix (S)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Frederic Bibollet-Ruche (F)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Ronnie M Russell (RM)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Stephanie Trimboli (S)

University of Massachusetts Medical School, Worcester, MA 01655, USA.

Andrew G Smith (AG)

WuXi AppTec Inc., Philadelphia, PA 19112, USA.

Yingying Li (Y)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Weimin Liu (W)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Alexa N Avitto (AN)

Gene Therapy Program, University of Pennsylvania, Philadelphia, PA 19104, USA.

Julia C DeVoto (JC)

Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.

Jesse Connell (J)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Angharad E Fenton-May (AE)

Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7FZ, UK.

Pierre Pellegrino (P)

Centre for Clinical Research in Infection and Sexual Health, Institute for Global Health, University College London, London WC1E 6JB, UK.

Ian Williams (I)

Centre for Clinical Research in Infection and Sexual Health, Institute for Global Health, University College London, London WC1E 6JB, UK.

Emmanouil Papasavvas (E)

Vaccine and Immunotherapy Center, Wistar Institute, Philadelphia, PA 19104, USA.

Julio C C Lorenzi (JCC)

Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA.

D Brenda Salantes (DB)

Century Therapeutics, Philadelphia, PA 19104, USA.

Felicity Mampe (F)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

M Alexandra Monroy (MA)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Yehuda Z Cohen (YZ)

Sanofi, Bridgewater, NJ 08807, USA.

Sonya Heath (S)

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Michael S Saag (MS)

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Luis J Montaner (LJ)

Vaccine and Immunotherapy Center, Wistar Institute, Philadelphia, PA 19104, USA.

Ronald G Collman (RG)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Janet M Siliciano (JM)

Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.

Robert F Siliciano (RF)

Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, MD 21205, USA.

Lindsey J Plenderleith (LJ)

Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3FL, UK.
Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh EH9 3FL, UK.

Paul M Sharp (PM)

Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3FL, UK.
Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh EH9 3FL, UK.

Marina Caskey (M)

Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA.

Michel C Nussenzweig (MC)

Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA.
Howard Hughes Medical Institute, Rockefeller University, New York, NY 10065, USA.

George M Shaw (GM)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Persephone Borrow (P)

Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7FZ, UK.

Katharine J Bar (KJ)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Beatrice H Hahn (BH)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. bhahn@pennmedicine.upenn.edu.
Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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