Peptide Receptor Radionuclide Therapy for a Phosphaturic Mesenchymal Tumor.
DOTATOC
Peptide receptor radionuclide therapy
Phosphaturic mesenchymal tumor
Radiofrequency ablation
Tumor-induced osteomalacia
Journal
Case reports in oncology
ISSN: 1662-6575
Titre abrégé: Case Rep Oncol
Pays: Switzerland
ID NLM: 101517601
Informations de publication
Date de publication:
Historique:
received:
15
07
2020
accepted:
19
07
2020
entrez:
14
1
2021
pubmed:
15
1
2021
medline:
15
1
2021
Statut:
epublish
Résumé
Tumor-induced osteomalacia is a very rare paraneoplastic syndrome. It can be caused by phosphaturic mesenchymal tumor (PMT), a generally benign tumor that produces fibroblast growth factor 23 (FGF-23), which can cause a severe renal phosphate wasting syndrome. Upon complete surgical removal of the tumor, FGF-23 normalizes and the osteomalacia is cured. In cases in which surgery is not feasible, radiofrequency ablation (RFA) is the treatment of choice. We describe a case with a PMT situated in the sacrum, in close proximity to the sacral plexus. Both surgery and RFA were considered potentially nerve damaging. Since the tumor showed expression of somatostatin receptors, we opted for a peptide receptor radionuclide therapy (PRRT) with
Identifiants
pubmed: 33442358
doi: 10.1159/000510334
pii: cro-0013-1373
pmc: PMC7772845
doi:
Types de publication
Case Reports
Langues
eng
Pagination
1373-1380Informations de copyright
Copyright © 2020 by S. Karger AG, Basel.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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