Sputter Deposition of Titanium on Poly(Methyl Methacrylate) Enhances Corneal Biocompatibility.
Boston Keratoprosthesis
artificial cornea
biocompatibility
poly(methyl methacrylate) (PMMA)
titanium sputtered coating
Journal
Translational vision science & technology
ISSN: 2164-2591
Titre abrégé: Transl Vis Sci Technol
Pays: United States
ID NLM: 101595919
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
09
02
2020
accepted:
15
11
2020
entrez:
14
1
2021
pubmed:
15
1
2021
medline:
15
5
2021
Statut:
epublish
Résumé
To evaluate titanium (Ti) sputtering of the poly(methyl methacrylate) (PMMA) stem of the Boston Keratoprosthesis (BK) as a method to enhance interfacial adhesion between the PMMA and the recipient corneal tissue. PMMA specimens were plasma treated with Ar/O By contact angle studies, the Ti coating improved PMMA hydrophilicity to match that of medical-grade Ti (Ti-6Al-4V-ELI). Ti sputtering of contact surfaces resulted in a plate-like morphology with increased surface roughness, without impacting the transparency of the BK optical component. Scratch testing indicated that the mechanical behavior of the Ti coating was similar to that of casted Ti, and the coating was stable in pull-off adhesion testing. Sputtered Ti film was highly biocompatible based on tests of cell viability, adhesion, proliferation, differentiation, collagen deposition, and keratocan expression, the properties of which exceeded those of uncoated PMMA and did not induce increased complement activation. Titanium coating of the BK stem generated a mechanically and biologically favorable interface, which may help to enhance corneal stromal adhesion and biocompatibility. Improving the biocompatibility of the BK PMMA stem may improve long-term outcomes of implantation.
Identifiants
pubmed: 33442495
doi: 10.1167/tvst.9.13.41
pii: TVST-20-2326
pmc: PMC7774111
doi:
Substances chimiques
Polymethyl Methacrylate
9011-14-7
Titanium
D1JT611TNE
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
41Subventions
Organisme : NEI NIH HHS
ID : K99 EY030553
Pays : United States
Informations de copyright
Copyright 2020 The Authors.
Déclaration de conflit d'intérêts
Disclosure: S. Sharifi, None; M.M. Islam, None; H. Sharifi, None; R. Islam, None; P.H. Nilsson, None; C.H. Dohlman, None; T.E. Mollnes, None; E.I. Paschalis, None; J. Chodosh, None
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