Robust Step Detection from Different Waist-Worn Sensor Positions: Implications for Clinical Studies.

Analyzing human gait with inertial sensors provides valuable insights into a wide range of health impairments, including many musculoskeletal and neurological diseases. A representative and reliable assessment of gait requires continuous monitoring over long periods and ideally takes place in the subjects' habitual environment (real-world). An inconsistent sensor wearing position can affect gait characterization and influence clinical study results, thus clinical study protocols are typically highly proscriptive, instructing all participants to wear the sensor in a uniform manner. This restrictive approach improves data quality but reduces overall adherence. In this work, we analyze the impact of altering the sensor wearing position around the waist on sensor signal and step detection. We demonstrate that an asymmetrically worn sensor leads to additional odd-harmonic frequency components in the frequency spectrum. We propose a robust solution for step detection based on autocorrelation to overcome sensor position variation (sensitivity = 0.99, precision = 0.99). The proposed solution reduces the impact of inconsistent sensor positioning on gait characterization in clinical studies, thus providing more flexibility to protocol implementation and more freedom to participants to wear the sensor in the position most comfortable to them. This work is a first step towards truly position-agnostic gait assessment in clinical settings.

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Copyright © 2020 by S. Karger AG, Basel.

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Ar.M., A.K., F.K., M.U., and B.M.E. are members of the IMI Mobilise-D consortium. I.C. is an employee of and holds stock options in Evidation Health. He has received payment for lecturing on Digital Health at the ETH Zurich and FHNW Muttenz. He is an Editorial Board Member at Karger Digital Biomarkers and a founding member of the Digital Medicine Society. H.H., Am.M., and Ar.M are employees of Novartis and hold stock in Novartis. M.T. is a Novartis employee and a student at University Erlangen-Nürnberg. B.M.E. reports grants outside the submitted work from Adidas AG, Agaplesion gAG, and Bosch Sensortec GmbH. He received compensation from lecturing for AbbVie Deutschland GmbH & Co. KG and Agaplesion gAG. He is a co-founder and co-owner of Portabiles GmbH and Portabiles HealthCare Technologies GmbH, and co-inventor of gait analysis patent application EP 16174268.9. F.K., M.U., and A.K. received funding from IMI Mobilise-D (grant agreement 820820).