Prolonged Unconsciousness Following Severe COVID-19.

Adult Aged COVID-19 / complications Coma / diagnostic imaging Female Humans Magnetic Resonance Imaging Male Middle Aged Respiratory Insufficiency / complications Time Factors Treatment Outcome White Matter / diagnostic imaging

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
09 03 2021
Historique:
received: 14 08 2020
accepted: 23 11 2020
pubmed: 15 1 2021
medline: 17 3 2021
entrez: 14 1 2021
Statut: ppublish

Résumé

We report a case series of patients with prolonged but reversible unconsciousness after coronavirus disease 2019 (COVID-19)-related severe respiratory failure. A case series of patients who were admitted to the intensive care unit due to COVID-19-related acute respiratory failure is described. After cessation of sedatives, the described cases all showed a prolonged comatose state. Diagnostic neurologic workup did not show signs of devastating brain injury. The clinical pattern of awakening started with early eye opening without obeying commands and persistent flaccid weakness in all cases. Time between cessation of sedatives to the first moment of being fully responsive with obeying commands ranged from 8 to 31 days. Prolonged unconsciousness in patients with severe respiratory failure due to COVID-19 can be fully reversible, warranting a cautious approach for prognostication based on a prolonged state of unconsciousness.

Identifiants

DOI: 10.1212/WNL.0000000000011355 PMID: 33443134 PMC: PMC8055315
pubmed: 33443134
pii: WNL.0000000000011355
doi: 10.1212/WNL.0000000000011355
pmc: PMC8055315
doi:

Types de publication

Case Reports Journal Article Multicenter Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

e1437-e1442

Commentaires et corrections

Type : CommentIn
Type : CommentIn
Type : CommentIn
Type : CommentIn

Informations de copyright

Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

Références

Acta Neuropathol. 2020 Jul;140(1):1-6
pubmed: 32449057
Ann Neurol. 2020 Oct;88(4):851-854
pubmed: 32613682
Brain Pathol. 2004 Jan;14(1):21-33
pubmed: 14997934
Radiology. 2020 Oct;297(1):E223-E227
pubmed: 32437314
Crit Care. 2020 Aug 8;24(1):491
pubmed: 32771053
Lancet. 2013 Jun 22;381(9884):2222
pubmed: 23791345
Neurol Clin Pract. 2018 Oct;8(5):e31-e33
pubmed: 30564507

Auteurs

Wilson F Abdo (WF)

From the Departments of Intensive Care (W.F.A., J.G.v.d.H.), Neurology (C.I.B., A.M.T.), and Radiology (F.J.A.M.), Radboud University Medical Center, Nijmegen; Departments of Intensive Care (B.P.G.), Neurology (A.A.A.C.M.W.), and Radiology (O.V.), Ziekenhuisgroep Twente, Almelo; Department of Intensive Care (M.P.B.), Catharina Hospital, Eindhoven; Department of Intensive Care (M.B.), Streekziekenhuis Winterswijk; and Department of Intensive Care (M.v.d.K.), Bernhoven Hospital, Uden, the Netherlands f.abdo@radboudumc.nl.

Catharina I Broerse (CI)

From the Departments of Intensive Care (W.F.A., J.G.v.d.H.), Neurology (C.I.B., A.M.T.), and Radiology (F.J.A.M.), Radboud University Medical Center, Nijmegen; Departments of Intensive Care (B.P.G.), Neurology (A.A.A.C.M.W.), and Radiology (O.V.), Ziekenhuisgroep Twente, Almelo; Department of Intensive Care (M.P.B.), Catharina Hospital, Eindhoven; Department of Intensive Care (M.B.), Streekziekenhuis Winterswijk; and Department of Intensive Care (M.v.d.K.), Bernhoven Hospital, Uden, the Netherlands.

Bart P Grady (BP)

From the Departments of Intensive Care (W.F.A., J.G.v.d.H.), Neurology (C.I.B., A.M.T.), and Radiology (F.J.A.M.), Radboud University Medical Center, Nijmegen; Departments of Intensive Care (B.P.G.), Neurology (A.A.A.C.M.W.), and Radiology (O.V.), Ziekenhuisgroep Twente, Almelo; Department of Intensive Care (M.P.B.), Catharina Hospital, Eindhoven; Department of Intensive Care (M.B.), Streekziekenhuis Winterswijk; and Department of Intensive Care (M.v.d.K.), Bernhoven Hospital, Uden, the Netherlands.

Agnes A A C M Wertenbroek (AAACM)

From the Departments of Intensive Care (W.F.A., J.G.v.d.H.), Neurology (C.I.B., A.M.T.), and Radiology (F.J.A.M.), Radboud University Medical Center, Nijmegen; Departments of Intensive Care (B.P.G.), Neurology (A.A.A.C.M.W.), and Radiology (O.V.), Ziekenhuisgroep Twente, Almelo; Department of Intensive Care (M.P.B.), Catharina Hospital, Eindhoven; Department of Intensive Care (M.B.), Streekziekenhuis Winterswijk; and Department of Intensive Care (M.v.d.K.), Bernhoven Hospital, Uden, the Netherlands.

Onno Vijlbrief (O)

From the Departments of Intensive Care (W.F.A., J.G.v.d.H.), Neurology (C.I.B., A.M.T.), and Radiology (F.J.A.M.), Radboud University Medical Center, Nijmegen; Departments of Intensive Care (B.P.G.), Neurology (A.A.A.C.M.W.), and Radiology (O.V.), Ziekenhuisgroep Twente, Almelo; Department of Intensive Care (M.P.B.), Catharina Hospital, Eindhoven; Department of Intensive Care (M.B.), Streekziekenhuis Winterswijk; and Department of Intensive Care (M.v.d.K.), Bernhoven Hospital, Uden, the Netherlands.

Marc P Buise (MP)

From the Departments of Intensive Care (W.F.A., J.G.v.d.H.), Neurology (C.I.B., A.M.T.), and Radiology (F.J.A.M.), Radboud University Medical Center, Nijmegen; Departments of Intensive Care (B.P.G.), Neurology (A.A.A.C.M.W.), and Radiology (O.V.), Ziekenhuisgroep Twente, Almelo; Department of Intensive Care (M.P.B.), Catharina Hospital, Eindhoven; Department of Intensive Care (M.B.), Streekziekenhuis Winterswijk; and Department of Intensive Care (M.v.d.K.), Bernhoven Hospital, Uden, the Netherlands.

Menno Beukema (M)

From the Departments of Intensive Care (W.F.A., J.G.v.d.H.), Neurology (C.I.B., A.M.T.), and Radiology (F.J.A.M.), Radboud University Medical Center, Nijmegen; Departments of Intensive Care (B.P.G.), Neurology (A.A.A.C.M.W.), and Radiology (O.V.), Ziekenhuisgroep Twente, Almelo; Department of Intensive Care (M.P.B.), Catharina Hospital, Eindhoven; Department of Intensive Care (M.B.), Streekziekenhuis Winterswijk; and Department of Intensive Care (M.v.d.K.), Bernhoven Hospital, Uden, the Netherlands.

Mark van der Kuil (M)

From the Departments of Intensive Care (W.F.A., J.G.v.d.H.), Neurology (C.I.B., A.M.T.), and Radiology (F.J.A.M.), Radboud University Medical Center, Nijmegen; Departments of Intensive Care (B.P.G.), Neurology (A.A.A.C.M.W.), and Radiology (O.V.), Ziekenhuisgroep Twente, Almelo; Department of Intensive Care (M.P.B.), Catharina Hospital, Eindhoven; Department of Intensive Care (M.B.), Streekziekenhuis Winterswijk; and Department of Intensive Care (M.v.d.K.), Bernhoven Hospital, Uden, the Netherlands.

Anil M Tuladhar (AM)

From the Departments of Intensive Care (W.F.A., J.G.v.d.H.), Neurology (C.I.B., A.M.T.), and Radiology (F.J.A.M.), Radboud University Medical Center, Nijmegen; Departments of Intensive Care (B.P.G.), Neurology (A.A.A.C.M.W.), and Radiology (O.V.), Ziekenhuisgroep Twente, Almelo; Department of Intensive Care (M.P.B.), Catharina Hospital, Eindhoven; Department of Intensive Care (M.B.), Streekziekenhuis Winterswijk; and Department of Intensive Care (M.v.d.K.), Bernhoven Hospital, Uden, the Netherlands.

Frederick J A Meijer (FJA)

From the Departments of Intensive Care (W.F.A., J.G.v.d.H.), Neurology (C.I.B., A.M.T.), and Radiology (F.J.A.M.), Radboud University Medical Center, Nijmegen; Departments of Intensive Care (B.P.G.), Neurology (A.A.A.C.M.W.), and Radiology (O.V.), Ziekenhuisgroep Twente, Almelo; Department of Intensive Care (M.P.B.), Catharina Hospital, Eindhoven; Department of Intensive Care (M.B.), Streekziekenhuis Winterswijk; and Department of Intensive Care (M.v.d.K.), Bernhoven Hospital, Uden, the Netherlands.

Johannes G van der Hoeven (JG)

From the Departments of Intensive Care (W.F.A., J.G.v.d.H.), Neurology (C.I.B., A.M.T.), and Radiology (F.J.A.M.), Radboud University Medical Center, Nijmegen; Departments of Intensive Care (B.P.G.), Neurology (A.A.A.C.M.W.), and Radiology (O.V.), Ziekenhuisgroep Twente, Almelo; Department of Intensive Care (M.P.B.), Catharina Hospital, Eindhoven; Department of Intensive Care (M.B.), Streekziekenhuis Winterswijk; and Department of Intensive Care (M.v.d.K.), Bernhoven Hospital, Uden, the Netherlands.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Prolonged Unconsciousness Following Severe COVID-19.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Prolonged Unconsciousness Following Severe COVID-19.
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Prolonged Unconsciousness Following Severe COVID-19.
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Perte de conscience › Coma › Prolonged Unconsciousness Following Severe COVID-19.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Prolonged Unconsciousness Following Severe COVID-19.
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Prolonged Unconsciousness Following Severe COVID-19.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Prolonged Unconsciousness Following Severe COVID-19.
questionsmedicales.fr › Maladies de l'appareil respiratoire › Troubles respiratoires › Insuffisance respiratoire › Prolonged Unconsciousness Following Severe COVID-19.
questionsmedicales.fr › Phénomènes physiques › Temps › Facteurs temps › Prolonged Unconsciousness Following Severe COVID-19.
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Prolonged Unconsciousness Following Severe COVID-19.
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Substance blanche › Prolonged Unconsciousness Following Severe COVID-19.