Patch Testing With Carmine 2.5% in Petrolatum by the North American Contact Dermatitis Group, 2011-2012.
Adolescent
Adult
Aged
Aged, 80 and over
Allergens
Carmine
/ adverse effects
Child
Child, Preschool
Coloring Agents
/ adverse effects
Cosmetics
/ adverse effects
Dermatitis, Allergic Contact
/ diagnosis
Female
Humans
Male
Middle Aged
Patch Tests
Petrolatum
/ adverse effects
Retrospective Studies
Young Adult
Journal
Dermatitis : contact, atopic, occupational, drug
ISSN: 2162-5220
Titre abrégé: Dermatitis
Pays: United States
ID NLM: 101207335
Informations de publication
Date de publication:
Historique:
pubmed:
15
1
2021
medline:
5
11
2021
entrez:
14
1
2021
Statut:
ppublish
Résumé
Carmine is a natural red dye that may cause allergic contact dermatitis. The aim of this study was to analyze patch test reactions to carmine (2.5% in petrolatum) and characterize carmine-positive patients. This study conducted a retrospective analysis of North American Contact Dermatitis Group data compiled between 2011 and 2012. Of 4240 patients patch tested to carmine, 132 (3.1%) had reactions with a final interpretation of "allergic" (positive). Carmine-positive patients were significantly more likely to be female (77.7% vs 68.3%; P = 0.0237) and have a final primary diagnosis of allergic contact dermatitis (74.8% vs 47.2%; P < 0.0001). As compared with carmine-negative patients, carmine-positive patients were significantly more likely to have involvement of all facial sites combined (48.1% vs 29.9%; P < 0.0001) and the lips (7.6% vs 3.6%; P = 0.0166). At final reading, most carmine reactions were weak (+; 64.9%). Approximately half (53.4%) were currently clinically relevant; identified sources were primarily personal care products (77.1%), especially makeup (31.4%) and lip products (8.6%). Weak patch test reactions to carmine should be interpreted with caution. Allergic contact dermatitis to carmine should be suspected in women with facial and/or lip dermatitis, especially those using carmine-containing cosmetics.
Sections du résumé
BACKGROUND
BACKGROUND
Carmine is a natural red dye that may cause allergic contact dermatitis.
OBJECTIVE
OBJECTIVE
The aim of this study was to analyze patch test reactions to carmine (2.5% in petrolatum) and characterize carmine-positive patients.
METHODS
METHODS
This study conducted a retrospective analysis of North American Contact Dermatitis Group data compiled between 2011 and 2012.
RESULTS
RESULTS
Of 4240 patients patch tested to carmine, 132 (3.1%) had reactions with a final interpretation of "allergic" (positive). Carmine-positive patients were significantly more likely to be female (77.7% vs 68.3%; P = 0.0237) and have a final primary diagnosis of allergic contact dermatitis (74.8% vs 47.2%; P < 0.0001). As compared with carmine-negative patients, carmine-positive patients were significantly more likely to have involvement of all facial sites combined (48.1% vs 29.9%; P < 0.0001) and the lips (7.6% vs 3.6%; P = 0.0166). At final reading, most carmine reactions were weak (+; 64.9%). Approximately half (53.4%) were currently clinically relevant; identified sources were primarily personal care products (77.1%), especially makeup (31.4%) and lip products (8.6%).
CONCLUSIONS
CONCLUSIONS
Weak patch test reactions to carmine should be interpreted with caution. Allergic contact dermatitis to carmine should be suspected in women with facial and/or lip dermatitis, especially those using carmine-containing cosmetics.
Identifiants
pubmed: 33443377
doi: 10.1097/DER.0000000000000643
pii: 01206501-900000000-99516
doi:
Substances chimiques
Allergens
0
Coloring Agents
0
Cosmetics
0
Petrolatum
8009-03-8
Carmine
CID8Z8N95N
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
94-100Informations de copyright
Copyright © 2021 American Contact Dermatitis Society. All Rights Reserved.
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