Lower Levels of Transaminases but Higher Levels of Serum Creatinine in Patients with Acute Hepatitis E in Comparison to Patients with Hepatitis A.
HAV
HEV
eGFR
extrahepatic manifestations
hepatitis A
hepatitis E
renal impairment
serum creatinine
Journal
Pathogens (Basel, Switzerland)
ISSN: 2076-0817
Titre abrégé: Pathogens
Pays: Switzerland
ID NLM: 101596317
Informations de publication
Date de publication:
12 Jan 2021
12 Jan 2021
Historique:
received:
11
12
2020
revised:
29
12
2020
accepted:
08
01
2021
entrez:
15
1
2021
pubmed:
16
1
2021
medline:
16
1
2021
Statut:
epublish
Résumé
In patients with hepatitis E virus (HEV) infections, extrahepatic, particularly renal and hematological manifestations, are increasingly reported in the medical literature but have never been studied compared to a control cohort. We retrospectively analyzed medical records of consecutive patients that were diagnosed with acute hepatitis E (AHE) (n = 69) or acute hepatitis A (AHA) (n = 46) at the University Medical Center Hamburg Eppendorf from January 2009 to August 2019 for demographical, clinical, and laboratory information. Patients with AHE had significantly lower median levels of ALAT (798 U/L) and total bilirubin (1.8 mg/dL) compared to patients with AHA (2326 U/L;
Identifiants
pubmed: 33445435
pii: pathogens10010060
doi: 10.3390/pathogens10010060
pmc: PMC7826713
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsches Zentrum für Infektionsforschung
ID : DZIF TI 07.001
Organisme : Else-Kröner-Fresenius-Stiftung
ID : 2019:EKFS10
Références
Emerg Microbes Infect. 2020 Dec;9(1):994-997
pubmed: 32366181
J Hepatol. 2016 Jan;64(1):37-43
pubmed: 26362822
Neurology. 2017 Aug 29;89(9):909-917
pubmed: 28768846
Clin Infect Dis. 2016 Jun 1;62(11):1464
pubmed: 27025819
Ann Intern Med. 1999 Mar 16;130(6):461-70
pubmed: 10075613
PLoS One. 2018 Oct 2;13(10):e0205039
pubmed: 30278075
J Clin Virol. 2010 May;48(1):73-4
pubmed: 20308017
Transplantation. 2012 Mar 27;93(6):617-23
pubmed: 22298032
Lancet. 2012 Jun 30;379(9835):2477-2488
pubmed: 22549046
Gut. 2017 Mar;66(3):561-562
pubmed: 27196597
J Clin Virol. 2019 Nov;120:20-26
pubmed: 31536936
Clin Biochem. 2019 Jan;63:24-31
pubmed: 30502317
J Clin Microbiol. 2008 Jul;46(7):2450-2
pubmed: 18480231
J Infect Dis. 2017 Apr 15;215(8):1197-1206
pubmed: 28199701
Liver Int. 2016 Apr;36(4):467-72
pubmed: 27005692
Clin Infect Dis. 2016 Feb 1;62(3):351-7
pubmed: 26429341
J Gen Virol. 2014 Jun;95(Pt 6):1266-1271
pubmed: 24622580
JAMA Neurol. 2017 Jan 1;74(1):26-33
pubmed: 27820624
Viruses. 2019 Jul 05;11(7):
pubmed: 31284447