Cytokines and Chemokines in SARS-CoV-2 Infections-Therapeutic Strategies Targeting Cytokine Storm.
COVID-19
SARS-CoV-2
chemokines
coronavirus
cytokine storm
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
12 Jan 2021
12 Jan 2021
Historique:
received:
27
11
2020
revised:
04
01
2021
accepted:
07
01
2021
entrez:
15
1
2021
pubmed:
16
1
2021
medline:
23
1
2021
Statut:
epublish
Résumé
The recently identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, the cause of coronavirus disease (COVID-19) and the associated ongoing pandemic, frequently leads to severe respiratory distress syndrome and pneumonia with fatal consequences. Although several factors of this infection and its consequences are not completely clear, the presence and involvement of specific chemokines is undoubtedly crucial for the development and progression of COVID-19. Cytokine storm and the often-resulting cytokine release syndrome (CRS) are pathophysiological hallmarks in COVID-19 infections related to its most severe and fatal cases. In this hyperinflammatory event, chemokines and other cytokines are highly upregulated and are therefore not fulfilling their beneficial function in the host response anymore but causing harmful effects. Here, we present the recent views on the involvement of chemokines and selected cytokines in COVID-19 and the therapeutics currently in clinical development targeting or interfering with them, discussing their potentials in the treatment of COVID-19 infections.
Identifiants
pubmed: 33445810
pii: biom11010091
doi: 10.3390/biom11010091
pmc: PMC7828218
pii:
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Autoimmun Rev. 2020 Jul;19(7):102568
pubmed: 32376398
J Allergy Clin Immunol. 2020 Jul;146(1):119-127.e4
pubmed: 32360286
Chest. 2009 Dec;136(6):1631-1643
pubmed: 19801579
Nat Med. 2020 Oct;26(10):1636-1643
pubmed: 32839624
Front Immunol. 2020 Aug 11;11:1991
pubmed: 32903476
medRxiv. 2020 May 05;:
pubmed: 32511656
Gastroenterology. 2001 Aug;121(2):246-54
pubmed: 11487533
Lancet Respir Med. 2020 Apr;8(4):420-422
pubmed: 32085846
J Clin Pathol. 2005 Oct;58(10):1057-63
pubmed: 16189151
J Med Virol. 2020 Oct;92(10):2042-2049
pubmed: 32369191
Leukemia. 2020 Oct;34(10):2815-2816
pubmed: 32879427
R I Med J (2013). 2016 Dec 1;99(12):19-22
pubmed: 27902994
BMJ Case Rep. 2020 Sep 15;13(9):
pubmed: 32933914
Int J Antimicrob Agents. 2020 May;55(5):105954
pubmed: 32234467
Chest. 2004 Sep;126(3):926-34
pubmed: 15364775
J Immunother Cancer. 2020 Aug;8(2):
pubmed: 32784217
Proc Natl Acad Sci U S A. 2020 Aug 11;117(32):18951-18953
pubmed: 32699149
J Allergy Clin Immunol. 2021 Jan;147(1):107-111
pubmed: 32920092
J Clin Invest. 1991 Oct;88(4):1121-7
pubmed: 1843454
Am J Physiol Lung Cell Mol Physiol. 2005 Jan;288(1):L3-15
pubmed: 15591040
Drug Des Devel Ther. 2017 May 24;11:1593-1603
pubmed: 28579757
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
Eur J Intern Med. 2020 Jun;76:36-42
pubmed: 32448770
PLoS Med. 2020 Sep 22;17(9):e1003346
pubmed: 32960881
Lancet Rheumatol. 2020 Aug;2(8):e457-ee458
pubmed: 32835251
Leukemia. 2020 Jul;34(7):1805-1815
pubmed: 32518419
Int J Antimicrob Agents. 2020 Sep;56(3):106103
pubmed: 32712333
Annu Rev Immunol. 2004;22:891-928
pubmed: 15032599
Best Pract Res Clin Rheumatol. 2012 Feb;26(1):157-65
pubmed: 22424201
J Leukoc Biol. 2021 Jan;109(1):55-66
pubmed: 32930456
Sci Rep. 2020 Oct 8;10(1):16826
pubmed: 33033405
Ann Rheum Dis. 2020 Oct;79(10):1381-1382
pubmed: 32376597
Clin Exp Rheumatol. 2020 May-Jun;38(3):529-532
pubmed: 32359035
Emerg Microbes Infect. 2020 Dec;9(1):761-770
pubmed: 32228226
N Engl J Med. 2020 Jun 18;382(25):2475-2477
pubmed: 32329975
Cell. 2020 Nov 12;183(4):1043-1057.e15
pubmed: 32970989
Expert Rev Clin Immunol. 2019 Aug;15(8):813-822
pubmed: 31219357
Emerg Microbes Infect. 2020 Dec;9(1):1123-1130
pubmed: 32475230
J Korean Med Sci. 2016 Nov;31(11):1717-1725
pubmed: 27709848
J Leukoc Biol. 2007 Aug;82(2):226-36
pubmed: 17329566
Am J Physiol Gastrointest Liver Physiol. 2004 Nov;287(5):G1062-9
pubmed: 15246961
Inflamm Bowel Dis. 2008 Jul;14(7):1000-11
pubmed: 18452220
Ther Adv Hematol. 2016 Dec;7(6):360-366
pubmed: 27904739
Annu Rev Pathol. 2011;6:147-63
pubmed: 20936936
EClinicalMedicine. 2020 Oct;27:100553
pubmed: 33043284
Signal Transduct Target Ther. 2020 Jun 19;5(1):100
pubmed: 32561706
Front Med (Lausanne). 2020 Oct 28;7:583897
pubmed: 33195334
J Med Virol. 2021 Jan;93(1):250-256
pubmed: 32592501
JCI Insight. 2020 Jun 18;5(12):
pubmed: 32427582
BMJ Open Diabetes Res Care. 2020 Apr;8(1):
pubmed: 32345579
Immunol Today. 1993 Mar;14(3):111-5
pubmed: 8466625
EClinicalMedicine. 2020 Jun 20;24:100418
pubmed: 32766537
Drug Des Devel Ther. 2009 Feb 06;2:151-61
pubmed: 19920903
J Allergy Clin Immunol. 2020 Sep;146(3):518-534.e1
pubmed: 32896310
Clin Exp Immunol. 1995 Aug;101(2):207-12
pubmed: 7648705
Clin Infect Dis. 2021 Jul 15;73(2):e445-e454
pubmed: 32651997
Int Immunol. 2015 Jan;27(1):55-62
pubmed: 25411043
Mol Med. 2020 Oct 29;26(1):97
pubmed: 33121429
Front Med (Lausanne). 2020 Oct 02;7:586221
pubmed: 33123544
J Clin Invest. 1999 Mar;103(6):807-15
pubmed: 10079101
Blood. 2005 Oct 1;106(7):2366-74
pubmed: 15860669
N Engl J Med. 2020 Dec 10;383(24):2333-2344
pubmed: 33085857
Lancet Infect Dis. 2020 Apr;20(4):400-402
pubmed: 32113509
Eur J Intern Med. 2020 Jun;76:31-35
pubmed: 32405160
J Virol. 2006 Mar;80(6):2684-93
pubmed: 16501078
Am J Respir Cell Mol Biol. 2005 Oct;33(4):319-27
pubmed: 16172252
Med Hypotheses. 2020 Nov;144:110053
pubmed: 32758889
Nat Med. 2020 Oct;26(10):1623-1635
pubmed: 32807934
Lancet Rheumatol. 2020 Jul;2(7):e393-e400
pubmed: 32835245
Sci Adv. 2021 Jan 1;7(1):
pubmed: 33187978
JAMA. 2012 Jun 20;307(23):2526-33
pubmed: 22797452
Immunology. 2005 May;115(1):1-20
pubmed: 15819693
Clin Immunol. 2020 Sep;218:108517
pubmed: 32585295
Immunity. 2019 Apr 16;50(4):812-831
pubmed: 30995501
Immunity. 2020 May 19;52(5):731-733
pubmed: 32325025
Arthritis Rheumatol. 2020 Dec;72(12):1990-1997
pubmed: 32602262
Acta Biomed. 2020 Sep 07;91(3):e2020008
pubmed: 32921706
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Int J Infect Dis. 2020 May;94:91-95
pubmed: 32173574
Ann Rheum Dis. 2020 Oct;79(10):1277-1285
pubmed: 32620597
Int J Med Sci. 2020 Jul 25;17(13):2052-2062
pubmed: 32788884
Crit Care. 2020 Jul 17;24(1):444
pubmed: 32680535
J Immunol. 2015 Feb 1;194(3):855-60
pubmed: 25596299
Chest. 2020 Oct;158(4):1397-1408
pubmed: 32553536
J Med Virol. 2020 Nov;92(11):2368-2370
pubmed: 32472703
Cytokine Growth Factor Rev. 2020 Jun;53:25-32
pubmed: 32446778
Lancet. 2008 Mar 22;371(9617):998-1006
pubmed: 18358927
Appl Transl Genom. 2013 May 26;2:3-16
pubmed: 27942440
Int J Infect Dis. 2020 Oct;99:291-297
pubmed: 32768693
Clin Infect Dis. 2021 Dec 6;73(11):e4082-e4089
pubmed: 33079180
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Int J Infect Dis. 2020 Dec;101:342-345
pubmed: 33039609
Nature. 1996 Jun 20;381(6584):667-73
pubmed: 8649512
Am J Respir Crit Care Med. 2020 Sep 15;202(6):812-821
pubmed: 32584597
Med Mal Infect. 2020 Aug;50(5):397-400
pubmed: 32387320
Hum Genomics. 2010 Oct;5(1):30-55
pubmed: 21106488
J Infect Dis. 2020 Aug 4;222(5):746-754
pubmed: 32563194
J Gen Virol. 2013 Dec;94(Pt 12):2679-2690
pubmed: 24077366
Visc Med. 2020 Aug;36(4):338-342
pubmed: 32999889
Am J Respir Crit Care Med. 2007 May 1;175(9):926-34
pubmed: 17290043
Lancet Rheumatol. 2020 Jun;2(6):e325-e331
pubmed: 32501454
Drugs Today (Barc). 2020 Jul;56(7):439-446
pubmed: 32648854
JCI Insight. 2020 Jul 9;5(13):
pubmed: 32501293
Nature. 2020 Jul;583(7816):437-440
pubmed: 32434211