Sleep disturbances in obsessive-compulsive disorder: influence of depression symptoms and trait anxiety.
Delayed sleep phase disorder
Depression
Obsessive-compulsive disorder
Sleep disorders
Sleep quality
Trait anxiety
Journal
BMC psychiatry
ISSN: 1471-244X
Titre abrégé: BMC Psychiatry
Pays: England
ID NLM: 100968559
Informations de publication
Date de publication:
14 01 2021
14 01 2021
Historique:
received:
13
10
2020
accepted:
28
12
2020
entrez:
15
1
2021
pubmed:
16
1
2021
medline:
27
4
2021
Statut:
epublish
Résumé
Sleep disturbances have been reported in obsessive-compulsive disorder (OCD) patients, with heterogeneous results. The aim of our study was to assess sleep function in OCD and to investigate the relationship between sleep and the severity of obsessive-compulsive (OC) symptoms, depressive symptoms and trait anxiety. Sleep quality was measured in 61 OCD patients and 100 healthy controls (HCs) using the Pittsburgh Sleep Quality Index (PSQI). Multiple linear regression was conducted to explore the association between sleep and psychopathological measures; a mediation analysis was also performed. OCD patients showed poor sleep quality and more sleep disturbances compared to HCs. The severity of depression, trait anxiety and OC symptomatology were correlated with poor sleep quality. Multiple linear regression analyses controlling for potential confounders revealed that the severity of depression and trait anxiety were independently related to poor sleep quality in OCD. A mediation analysis showed that both the severity of trait anxiety and depression mediate the relationship between the severity of OC symptoms and poor sleep quality among patients with OCD. Our findings support the existence of sleep disturbances in OCD. Trait anxiety and depression play a key role in sleep quality among OCD patients.
Sections du résumé
BACKGROUND
Sleep disturbances have been reported in obsessive-compulsive disorder (OCD) patients, with heterogeneous results. The aim of our study was to assess sleep function in OCD and to investigate the relationship between sleep and the severity of obsessive-compulsive (OC) symptoms, depressive symptoms and trait anxiety.
METHODS
Sleep quality was measured in 61 OCD patients and 100 healthy controls (HCs) using the Pittsburgh Sleep Quality Index (PSQI). Multiple linear regression was conducted to explore the association between sleep and psychopathological measures; a mediation analysis was also performed.
RESULTS
OCD patients showed poor sleep quality and more sleep disturbances compared to HCs. The severity of depression, trait anxiety and OC symptomatology were correlated with poor sleep quality. Multiple linear regression analyses controlling for potential confounders revealed that the severity of depression and trait anxiety were independently related to poor sleep quality in OCD. A mediation analysis showed that both the severity of trait anxiety and depression mediate the relationship between the severity of OC symptoms and poor sleep quality among patients with OCD.
CONCLUSIONS
Our findings support the existence of sleep disturbances in OCD. Trait anxiety and depression play a key role in sleep quality among OCD patients.
Identifiants
pubmed: 33446149
doi: 10.1186/s12888-021-03038-z
pii: 10.1186/s12888-021-03038-z
pmc: PMC7809865
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
42Références
J Clin Psychiatry. 1998;59 Suppl 20:22-33;quiz 34-57
pubmed: 9881538
Drugs. 2005;65(7):927-47
pubmed: 15892588
Arch Gen Psychiatry. 1982 Dec;39(12):1372-7
pubmed: 7149896
J Clin Sleep Med. 2016 Mar;12(3):351-5
pubmed: 26446247
Psychiatry Res. 2007 Jul 30;152(1):29-35
pubmed: 17316824
J Anxiety Disord. 2017 Jun;49:31-39
pubmed: 28388457
Behav Res Methods. 2008 Aug;40(3):879-91
pubmed: 18697684
Am J Psychiatry. 2010 Jun;167(6):686-93
pubmed: 20360319
Sleep Med Rev. 2013 Dec;17(6):465-74
pubmed: 23499210
Psychiatry Res. 1989 May;28(2):193-213
pubmed: 2748771
Behav Sleep Med. 2011;9(2):107-16
pubmed: 21491233
CNS Spectr. 2008 May;13(5):406-13
pubmed: 18496478
Eur Arch Psychiatry Clin Neurosci. 2007 Apr;257(3):173-82
pubmed: 17149537
Sleep. 2013 Jul 1;36(7):1059-1068
pubmed: 23814343
Psychol Med. 1986 Feb;16(1):135-40
pubmed: 3961039
Neurosci Biobehav Rev. 2015 Apr;51:100-7
pubmed: 25603315
J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62
pubmed: 14399272
Psychiatry Res. 1998 Sep 21;80(3):257-63
pubmed: 9796941
Psychiatry Res. 2019 Jan;271:214-219
pubmed: 30502557
Psychiatry Res. 2016 Oct 30;244:279-83
pubmed: 27512915
Biol Psychiatry. 2013 Aug 15;74(4):242-9
pubmed: 23558300
J Behav Ther Exp Psychiatry. 2016 Mar;50:23-32
pubmed: 25989071
Eur Arch Psychiatry Clin Neurosci. 1994;243(5):273-8
pubmed: 8172942
Arch Gen Psychiatry. 1989 Nov;46(11):1012-6
pubmed: 2510699
JAMA Psychiatry. 2018 Oct 1;75(10):1052-1061
pubmed: 30046833
World Psychiatry. 2007 Jun;6(2):108-11
pubmed: 18235868
Psychiatry Res Neuroimaging. 2017 Jul 30;265:26-34
pubmed: 28500965
Genes Brain Behav. 2020 Apr;19(4):e12644
pubmed: 31997568
Curr Psychiatry Rep. 2015 Sep;17(9):73
pubmed: 26216591
Mol Psychiatry. 2010 Jan;15(1):53-63
pubmed: 18725912
Psychol Bull. 2016 Sep;142(9):969-990
pubmed: 27416139
Sleep Med Rev. 2013 Oct;17(5):377-90
pubmed: 23391633
Curr Psychiatry Rep. 2019 Jun 4;21(7):54
pubmed: 31165330
J Psychiatr Res. 2014 Oct;57:101-7
pubmed: 25038630
J Affect Disord. 2020 Apr 1;266:413-416
pubmed: 32056907
J Clin Sleep Med. 2011 Oct 15;7(5 Suppl):S6-8
pubmed: 22003334
Int J Psychiatry Clin Pract. 2002;6(1):15-21
pubmed: 24931884
Sleep Med. 2015 Sep;16(9):1049-55
pubmed: 26298778