[Histopathological features due to the SARS-CoV-2].
Les lésions histologiques associées à l’infection par le SARS-CoV-2.
Ancillary tools
Autopsie
Autopsy
COVID-19
Pathologie
Pathology
Pathophysiology
Physiopathologie
Études ancillaires
Journal
Annales de pathologie
ISSN: 0242-6498
Titre abrégé: Ann Pathol
Pays: France
ID NLM: 8106337
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
07
11
2020
revised:
23
12
2020
accepted:
28
12
2020
pubmed:
16
1
2021
medline:
20
2
2021
entrez:
15
1
2021
Statut:
ppublish
Résumé
The infection due to the SARS-CoV-2 leads lesions mainly observed at the respiratory tract level, but not exclusively. The analyses of these lesions benefited from different autopsy studies. Thus, these lesions were observed in different organs, tissues and cells. These observations allowed us to rapidly improve the knowledge of the pathophysiological mechanisms associated with this emergent infectious disease. The virus can be detected in formalin fixed paraffin embedded tissues using immunohistochemistry, in situ hybridization, molecular biology and/or electron microscopy approaches. However, many uncertainties are still present concerning the direct role of the SARS-CoV-2 on the different lesions observed in different organs, outside the lung, such as the heart, the brain, the liver, the gastrointestinal tract, the kidney and the skin. In this context, it is pivotal to keep going to increase the different tissue and cellular studies in the COVID-19 positive patients aiming to better understanding the consequences of this new infectious disease, notably considering different epidemiological and co-morbidities associated factors. This could participate to the development of new therapeutic strategies too. The purpose of this review is to describe the main histological and cellular lesions associated with the infection due to the SARS-CoV-2.
Identifiants
pubmed: 33446414
pii: S0242-6498(20)30285-6
doi: 10.1016/j.annpat.2020.12.009
pmc: PMC7773006
pii:
doi:
Types de publication
Journal Article
Review
Langues
fre
Sous-ensembles de citation
IM
Pagination
9-22Informations de copyright
Copyright © 2020 Elsevier Masson SAS. All rights reserved.
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