An interplay of NOX1-derived ROS and oxygen determines the spermatogonial stem cell self-renewal efficiency under hypoxia.

Adult Germline Stem Cells / cytology Animals Cell Division / genetics Cell Hypoxia / physiology Cell Proliferation / genetics Cells, Cultured DNA Topoisomerases, Type I / genetics Gene Expression Regulation, Developmental Hypoxia-Inducible Factor 1, alpha Subunit / deficiency Mice Mice, Knockout Mitochondria / physiology NADPH Oxidase 1 / metabolism Oxygen / metabolism Reactive Oxygen Species / metabolism
Hif1 reactive oxygen species spermatogonia

Journal

Genes & development
ISSN: 1549-5477
Titre abrégé: Genes Dev
Pays: United States
ID NLM: 8711660

Informations de publication

Date de publication:
01 02 2021
Historique:
received: 22 05 2020
accepted: 18 12 2020
pubmed: 16 1 2021
medline: 4 9 2021
entrez: 15 1 2021
Statut: ppublish

Résumé

Reactive oxygen species (ROS) produced by NADPH1 oxidase 1 (NOX1) are thought to drive spermatogonial stem cell (SSC) self-renewal through feed-forward production of ROS by the ROS-BCL6B-NOX1 pathway. Here we report the critical role of oxygen on ROS-induced self-renewal. Cultured SSCs proliferated poorly and lacked BCL6B expression under hypoxia despite increase in mitochondria-derived ROS. Due to lack of ROS amplification under hypoxia, NOX1-derived ROS were significantly reduced, and

Identifiants

DOI: 10.1101/gad.339903.120 PMID: 33446567 PMC: PMC7849365
pubmed: 33446567
pii: gad.339903.120
doi: 10.1101/gad.339903.120
pmc: PMC7849365
doi:

Substances chimiques

Hif1a protein, mouse 0
Hypoxia-Inducible Factor 1, alpha Subunit 0
Reactive Oxygen Species 0
NADPH Oxidase 1 EC 1.6.3.-
NOX1 protein, mouse EC 1.6.3.-
DNA Topoisomerases, Type I EC 5.99.1.2
Top1mt protein, mouse EC 5.99.1.2
Oxygen S88TT14065

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

250-260

Informations de copyright

© 2021 Morimoto et al.; Published by Cold Spring Harbor Laboratory Press.

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Auteurs

Hiroko Morimoto (H)

Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.

Takuya Yamamoto (T)

Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan.
AMED-CREST, Chiyodaku, Tokyo 100-0004, Japan.
Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto 606-8501, Japan.
Medical risk Avoidance Based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP), Kyoto 606-8507, Japan.
ORCID: 0000-0002-0022-3947

Takehiro Miyazaki (T)

Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.

Narumi Ogonuki (N)

Bioresource Engineering Division, RIKEN BioResource Research Center, Ibaraki 305-0074, Japan.

Atsuo Ogura (A)

Bioresource Engineering Division, RIKEN BioResource Research Center, Ibaraki 305-0074, Japan.

Takashi Tanaka (T)

Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.

Mito Kanatsu-Shinohara (M)

Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.

Chihiro Yabe-Nishimura (C)

Department of Pharmacology, Kyoto Prefectural University of Medicine, Kyoto 606-8566, Japan.

Hongliang Zhang (H)

Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, Maryland 20892, USA.

Yves Pommier (Y)

Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, Maryland 20892, USA.

Andreas Trumpp (A)

Division of Stem Cells and Cancer, Deutsches Krebsforshungszentrum (DKFZ), 69120 Heidelberg, Germany.

Takashi Shinohara (T)

Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
AMED-CREST, Chiyodaku, Tokyo 100-0004, Japan.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules souches › Cellules souches adultes › Cellules souches germinales adultes › An interplay of NOX1-derived ROS and oxygen...
questionsmedicales.fr › Eucaryotes › Animaux › An interplay of NOX1-derived ROS and oxygen...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Division cellulaire › An interplay of NOX1-derived ROS and oxygen...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Respiration cellulaire › Hypoxie cellulaire › An interplay of NOX1-derived ROS and oxygen...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › An interplay of NOX1-derived ROS and oxygen...
questionsmedicales.fr › Cellules › Cellules cultivées › An interplay of NOX1-derived ROS and oxygen...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines liant le poly-adp-ribose › ADN topoisomérases de type I › An interplay of NOX1-derived ROS and oxygen...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes au cours du développement › An interplay of NOX1-derived ROS and oxygen...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique hélice-boucle-hélice › Facteur-1 induit par l'hypoxie › Sous-unité alpha du facteur-1 induit par l'hypoxie › An interplay of NOX1-derived ROS and oxygen...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › An interplay of NOX1-derived ROS and oxygen...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › An interplay of NOX1-derived ROS and oxygen...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › An interplay of NOX1-derived ROS and oxygen...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › NADPH oxidase › NADPH Oxidase 1 › An interplay of NOX1-derived ROS and oxygen...
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Oxygène › An interplay of NOX1-derived ROS and oxygen...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › An interplay of NOX1-derived ROS and oxygen...