Protein-bound molybdenum cofactor is bioavailable and rescues molybdenum cofactor-deficient
C. elegans
E. coli
molybdenum cofactor
sulfite oxidase
Journal
Genes & development
ISSN: 1549-5477
Titre abrégé: Genes Dev
Pays: United States
ID NLM: 8711660
Informations de publication
Date de publication:
01 02 2021
01 02 2021
Historique:
received:
19
10
2020
accepted:
01
12
2020
pubmed:
16
1
2021
medline:
4
9
2021
entrez:
15
1
2021
Statut:
ppublish
Résumé
The molybdenum cofactor (Moco) is a 520-Da prosthetic group that is synthesized in all domains of life. In animals, four oxidases (among them sulfite oxidase) use Moco as a prosthetic group. Moco is essential in animals; humans with mutations in genes that encode Moco biosynthetic enzymes display lethal neurological and developmental defects. Moco supplementation seems a logical therapy; however, the instability of Moco has precluded biochemical and cell biological studies of Moco transport and bioavailability. The nematode
Identifiants
pubmed: 33446569
pii: gad.345579.120
doi: 10.1101/gad.345579.120
pmc: PMC7849362
doi:
Substances chimiques
Coenzymes
0
Metalloproteins
0
Molybdenum Cofactors
0
Pteridines
0
molybdenum cofactor
ATN6EG42UQ
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
212-217Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM044619
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021 Warnhoff et al.; Published by Cold Spring Harbor Laboratory Press.
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