Therapy Algorithms for the Diagnosis and Treatment of Patients with Early and Advanced Breast Cancer.

BACKGROUND

In order to offer optimal treatment approaches based on available evidence, the Commission Breast of the Working Group Gynecologic Oncology (AGO) of the German Cancer Society developed therapy algorithms for eight complex treatment situations in primary and advanced breast cancer.

SUMMARY

Therapy algorithms for the following complex treatment situations are outlined in this paper: (neo)adjuvant therapy of human epidermal growth factor receptor 2 (HER2)-positive breast cancer; axillary surgery and neoadjuvant chemotherapy; adjuvant endocrine therapy in premenopausal patients; adjuvant endocrine therapy in postmenopausal patients; hormone receptor (HR)-positive/HER2-negative metastatic breast cancer: strategies; HR-positive/HER2-negative metastatic breast cancer: endocrine-based first-line treatment; HER2-positive metastatic breast cancer: first to third-line; metastatic triple-negative breast cancer.

KEY MESSAGES

The therapy options shown in these algorithms are based on the current AGO recommendations updated in January 2020 but cannot represent all evidence-based treatment options. Prior therapies, performance status, comorbidities, patient preference, etc. must be taken into account for the actual treatment choice. Therefore, in individual cases, other evidence-based treatment options not listed here may also be appropriate and justified.

Informations de copyright

Copyright © 2020 by S. Karger AG, Basel.

Déclaration de conflit d'intérêts

A. Schneeweiss reports grants from Celgene, Roche, and Abb­Vie, personal fees from Roche, AstraZeneca, Celgene, Pfizer, Novartis, MSD, Tesaro, and Lilly, and travel grants from Roche and Celgene. I. Bauerfeind reports honoraria from Novartis, Celgene, Pfizer, Roche, GSK, and Lilly. T. Fehm reports honoraria from Daiichi Sankyo, Novartis, Roche, Lilly, MSD, HelloHealthcare, Amgen, AstraZeneca, Pfizer, and Olympus. W. Janni reports grants and personal fees from Amgen, AstraZeneca, Daiichi Sankyo, Lilly, MSD, MSB, Novartis, Pfizer, and Roche. C. Thomssen reports honoraria from Amgen, AstraZeneca, Celgene, Daiichi Sankyo, Eisai, Lilly, MSD, Mylan, Nanostring, Novartis, Pfizer, Pierre Fabre, Puma, Roche, and Vifor. I. Witzel reports honoraria from Amgen, Celgene, Daiichi Sankyo, Lilly, MSD, Novartis, Pfizer, Roche, and TEVA. A. Wöckel reports personal fees from Amgen, Novartis, Eisai, Celgene, Pfizer, Tesaro, TEVA, Hexal Lilly, Roche, AstraZeneca, Sirtex, MSD, and Genomic Health. V. Müller reports institutional research support from Novartis, Roche, Seattle Genetics, and Genentech, honoraria from Amgen, AstraZeneca, Daiichi Sankyo, Eisai, Pfizer, MSD, Novartis, Roche, Teva, Seattle Genetics, Genomic Health, Hexal, Pierre Fabre, Amgen, ClinSol, MSD, Lilly, Tesaro, and Nektar, and travel grants from Roche, Pfizer, and Daiichi Sankyo.