Reduction of T-Box 15 gene expression in tumor tissue is a prognostic biomarker for patients with hepatocellular carcinoma.
genome-wide analysis
hepatocellular carcinoma
methylation
prognostic biomarker
tumor suppressor gene
Journal
Oncotarget
ISSN: 1949-2553
Titre abrégé: Oncotarget
Pays: United States
ID NLM: 101532965
Informations de publication
Date de publication:
29 Dec 2020
29 Dec 2020
Historique:
received:
28
10
2020
accepted:
08
12
2020
entrez:
15
1
2021
pubmed:
16
1
2021
medline:
16
1
2021
Statut:
epublish
Résumé
Genome-wide analysis is widely applied to detect molecular alterations during oncogenesis and tumor progression. We analyzed DNA methylation profiles of hepatocellular carcinoma (HCC), and investigated the clinical role of most heypermethylated of tumor, encodes T-box 15 (TBX15), which was originally involved in mesodermal differentiation. We conducted a genome-wide analysis of DNA methylation of tumor and non-tumor tissue of 15 patients with HCC, and revealed
Identifiants
pubmed: 33447348
doi: 10.18632/oncotarget.27852
pii: 27852
pmc: PMC7779253
doi:
Types de publication
Journal Article
Langues
eng
Pagination
4803-4812Informations de copyright
Copyright: © 2020 Morine et al.
Déclaration de conflit d'intérêts
CONFLICTS OF INTEREST Authors have no conflicts of interest to declare.
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