Lipid-Producing Ciliochoroidal Melanoma with Expression of HMG-CoA Reductase.
Cholesterol
HMG-CoA reductase
Lipids
Statin
Uveal melanoma
Journal
Ocular oncology and pathology
ISSN: 2296-4681
Titre abrégé: Ocul Oncol Pathol
Pays: Switzerland
ID NLM: 101656139
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
12
05
2020
accepted:
22
07
2020
entrez:
15
1
2021
pubmed:
16
1
2021
medline:
16
1
2021
Statut:
ppublish
Résumé
Uveal melanoma (UM) is the commonest primary intraocular malignancy in adults. There is limited published data on lipid production in UM. Here, we describe the clinical, histological, immunohistochemical, and molecular findings in a ciliochoroidal melanoma with lipid production and expression of the enzyme HMG-CoA reductase. This case highlights an unusual UM tumour phenotype with a high-risk molecular metastatic profile and discusses tumour lipogenesis and activation of the mevalonate pathway as a potential therapeutic target in managing lipidised ciliochoroidal UM.
Identifiants
pubmed: 33447591
doi: 10.1159/000510393
pii: oop-0006-0416
pmc: PMC7772867
doi:
Types de publication
Case Reports
Langues
eng
Pagination
416-421Informations de copyright
Copyright © 2020 by S. Karger AG, Basel.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to declare.
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