HBcAb Positivity Increases the Risk of Severe Hepatic Fibrosis Development in HIV/HCV-Positive Subjects From the ICONA Italian Cohort of HIV-Infected Patients.
HBV
HIV/HBV coinfection
OBI
anti-HBc
liver fibrosis
Journal
Open forum infectious diseases
ISSN: 2328-8957
Titre abrégé: Open Forum Infect Dis
Pays: United States
ID NLM: 101637045
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
16
09
2020
accepted:
11
11
2020
entrez:
15
1
2021
pubmed:
16
1
2021
medline:
16
1
2021
Statut:
epublish
Résumé
The aim of this study was to investigate the impact of anti-HBc (HBcAb) positivity on the progression of liver fibrosis (Fibrosis-4 score >3.25) in the Italian cohort of HIV-infected individuals naïve to antiretroviral treatment (ICONA). All patients with FIB-4 <3.25 at baseline were evaluated prospectively: 6966 people with HIV (PWH) were screened and classified based on hepatitis B virus (HBV) and hepatitis C virus (HCV) serology. Patients who were HBcAb+/HCV-/HBs antigen (HBsAg)- and HCV+/HBcAb+/HBsAg- or HBsAg+/HBcAb+/HCV- had CD4+ cell counts below the nadir and significantly higher prevalence of AIDS diagnosis at baseline than the other groups ( HBcAb+ contributes to liver damage in HIV+/HCV+/HBcAb+/HBsAg- subjects. A careful monitoring for signs of previous HBV infection is needed in this kind of patients.
Sections du résumé
BACKGROUND
BACKGROUND
The aim of this study was to investigate the impact of anti-HBc (HBcAb) positivity on the progression of liver fibrosis (Fibrosis-4 score >3.25) in the Italian cohort of HIV-infected individuals naïve to antiretroviral treatment (ICONA).
METHODS
METHODS
All patients with FIB-4 <3.25 at baseline were evaluated prospectively: 6966 people with HIV (PWH) were screened and classified based on hepatitis B virus (HBV) and hepatitis C virus (HCV) serology.
RESULTS
RESULTS
Patients who were HBcAb+/HCV-/HBs antigen (HBsAg)- and HCV+/HBcAb+/HBsAg- or HBsAg+/HBcAb+/HCV- had CD4+ cell counts below the nadir and significantly higher prevalence of AIDS diagnosis at baseline than the other groups (
CONCLUSIONS
CONCLUSIONS
HBcAb+ contributes to liver damage in HIV+/HCV+/HBcAb+/HBsAg- subjects. A careful monitoring for signs of previous HBV infection is needed in this kind of patients.
Identifiants
pubmed: 33447635
doi: 10.1093/ofid/ofaa566
pii: ofaa566
pmc: PMC7781466
doi:
Types de publication
Journal Article
Langues
eng
Pagination
ofaa566Investigateurs
A d'Arminio Monforte
(A)
A Antinori
(A)
M Andreoni
(M)
A Castagna
(A)
F Castelli
(F)
R Cauda
(R)
G Di Perri
(G)
M Galli
(M)
R Iardino
(R)
G Ippolito
(G)
A Lazzarin
(A)
G C Marchetti
(GC)
G Rezza
(G)
F von Schloesser
(F)
P Viale
(P)
A d'Arminio Monforte
(A)
A Antinori
(A)
A Castagna
(A)
F Ceccherini-Silberstein
(F)
A Cozzi-Lepri
(A)
E Girardi
(E)
A Gori
(A)
S Lo Caputo
(S)
F Maggiolo
(F)
C Mussini
(C)
M Puoti
(M)
C F Perno
(CF)
A Antinori
(A)
F Bai
(F)
A Bandera
(A)
S Bonora
(S)
M Borderi
(M)
A Calcagno
(A)
M R Capobianchi
(MR)
A Castagna
(A)
F Ceccherini-Silberstein
(F)
S Cicalini
(S)
A Cingolani
(A)
P Cinque
(P)
A Cozzi-Lepri
(A)
A d'Arminio Monforte
(A)
A Di Biagio
(A)
R Gagliardini
(R)
E Girardi
(E)
N Gianotti
(N)
A Gori
(A)
G Guaraldi
(G)
G Lapadula
(G)
M Lichtner
(M)
A Lai
(A)
S Lo Caputo
(S)
G Madeddu
(G)
F Maggiolo
(F)
G Marchetti
(G)
E Merlini
(E)
C Mussini
(C)
S Nozza
(S)
C F Perno
(CF)
S Piconi
(S)
C Pinnetti
(C)
M Puoti
(M)
E Quiros Roldan
(E)
R Rossotti
(R)
S Rusconi
(S)
M M Santoro
(MM)
A Saracino
(A)
L Sarmati
(L)
V Spagnuolo
(V)
V Svicher
(V)
L Taramasso
(L)
A Cozzi-Lepri
(A)
I Fanti
(I)
L Galli
(L)
P Lorenzini
(P)
A Rodanó
(A)
M Macchia
(M)
A Tavelli
(A)
A Bove
(A)
A Camposeragna
(A)
M Errico
(M)
M Manfredini
(M)
A Perziano
(A)
V Calvino
(V)
F Carletti
(F)
S Carrara
(S)
A Di Caro
(A)
S Graziano
(S)
F Petroni
(F)
G Prota
(G)
S Truffa
(S)
A Giacometti
(A)
A Costantini
(A)
V Barocci
(V)
G Angarano
(G)
L Monno
(L)
E Milano
(E)
F Maggiolo
(F)
C Suardi
(C)
P Viale
(P)
V Donati
(V)
G Verucchi
(G)
F Castelnuovo
(F)
C Minardi
(C)
E Quiros Roldan
(E)
B Menzaghi
(B)
C Abeli
(C)
L Chessa
(L)
F Pes
(F)
B Cacopardo
(B)
B Celesia
(B)
J Vecchiet
(J)
K Falasca
(K)
A Pan
(A)
S Lorenzotti
(S)
L Sighinolfi
(L)
D Segala
(D)
P Blanc
(P)
F Vichi
(F)
G Cassola
(G)
M Bassetti
(M)
A Alessandrini
(A)
N Bobbio
(N)
G Mazzarello
(G)
M Lichtner
(M)
L Fondaco
(L)
P Bonfanti
(P)
C Molteni
(C)
A Chiodera
(A)
P Milini
(P)
G Nunnari
(G)
G Pellicanò
(G)
A d'Arminio Monforte
(A)
M Galli
(M)
A Lazzarin
(A)
G Rizzardini
(G)
M Puoti
(M)
A Castagna
(A)
E S Cannizzo
(ES)
M C Moioli
(MC)
R Piolini
(R)
D Bernacchia
(D)
A Poli
(A)
C Tincati
(C)
C Mussini
(C)
C Puzzolante
(C)
C Migliorino
(C)
G Lapadula
(G)
V Sangiovanni
(V)
G Borgia
(G)
V Esposito
(V)
G Di Flumeri
(G)
I Gentile
(I)
V Rizzo
(V)
A M Cattelan
(AM)
S Marinello
(S)
A Cascio
(A)
M Trizzino
(M)
D Francisci
(D)
E Schiaroli
(E)
G Parruti
(G)
F Sozio
(F)
C Lazzaretti
(C)
R Corsini
(R)
M Andreoni
(M)
A Antinori
(A)
R Cauda
(R)
A Cristaudo
(A)
V Vullo
(V)
R Acinapura
(R)
S Lamonica
(S)
M Capozzi
(M)
A Mondi
(A)
A Cingolani
(A)
M Rivano Capparuccia
(M)
G Iaiani
(G)
A Latini
(A)
G Onnelli
(G)
M M Plazzi
(MM)
G De Girolamo
(G)
A Vergori
(A)
M Cecchetto
(M)
F Viviani
(F)
G Madeddu
(G)
A De Vito
(A)
B Rossetti
(B)
F Montagnani
(F)
A Franco
(A)
R Fontana Del Vecchio
(R)
C Di Giuli
(C)
P Caramello
(P)
G Di Perri
(G)
S Bonora
(S)
G C Orofino
(GC)
M Sciandra
(M)
A Londero
(A)
V Manfrin
(V)
G Battagin
(G)
G Starnini
(G)
A Ialungo
(A)
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
Références
AIDS. 2017 Nov 28;31(18):2525-2532
pubmed: 28926400
J Med Virol. 2019 Apr;91(4):630-641
pubmed: 30431661
Dig Liver Dis. 2015 Mar;47(3):218-25
pubmed: 25544657
J Int AIDS Soc. 2017 Feb 28;20(1):21426
pubmed: 28362068
Curr Opin HIV AIDS. 2011 Nov;6(6):472-7
pubmed: 21918438
Clin Infect Dis. 2016 Nov 1;63(9):1160-1167
pubmed: 27506682
Arch Intern Med. 2006 Aug 14-28;166(15):1632-41
pubmed: 16908797
AIDS. 2017 Sep 24;31(15):2035-2052
pubmed: 28692539
HIV Med. 2014 Mar;15(3):189-92
pubmed: 24118868
J Trop Med. 2014;2014:796121
pubmed: 24868208
J Hepatol. 2008 Oct;49(4):652-7
pubmed: 18715666
Open Forum Infect Dis. 2020 Jun 25;7(7):ofaa226
pubmed: 32665961
AIDS Patient Care STDS. 2016 May;30(5):200-7
pubmed: 27158847
Open Forum Infect Dis. 2017 Sep 13;4(4):ofx195
pubmed: 29062862
J Acquir Immune Defic Syndr. 2016 May 1;72(1):e14-7
pubmed: 26829660
PLoS One. 2009;4(2):e4623
pubmed: 19247452
J Viral Hepat. 2014 Mar;21(3):153-62
pubmed: 24438677
Curr HIV/AIDS Rep. 2018 Apr;15(2):172-181
pubmed: 29572624
Infection. 2009 Oct;37(5):445-9
pubmed: 19669092
J Med Virol. 2009 Mar;81(3):441-5
pubmed: 19152397
Clin Infect Dis. 2010 Feb 15;50(4):502-11
pubmed: 20085465
AIDS. 2005 Sep 2;19(13):1361-5
pubmed: 16103766
Hepatology. 1998 Jun;27(6):1717-22
pubmed: 9620348
Liver Int. 2012 Feb;32(2):231-40
pubmed: 21745272
AIDS. 2004 Oct 21;18(15):2039-45
pubmed: 15577625
J Hepatol. 2017 Mar;66(3):645-654
pubmed: 27771453
J Acquir Immune Defic Syndr. 2007 Apr 15;44(5):606-7
pubmed: 17413991
Virol J. 2012 Aug 09;9:157
pubmed: 22877244
PLoS One. 2017 Jun 7;12(6):e0179035
pubmed: 28591184
Int J STD AIDS. 2017 Jun;28(7):636-650
pubmed: 26868158