Selective vulnerability of inhibitory networks in multiple sclerosis.
Interneurons
Multiple sclerosis
Myelin
Neurodegeneration
Synapses
Journal
Acta neuropathologica
ISSN: 1432-0533
Titre abrégé: Acta Neuropathol
Pays: Germany
ID NLM: 0412041
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
12
10
2020
accepted:
22
12
2020
revised:
21
12
2020
pubmed:
16
1
2021
medline:
6
11
2021
entrez:
15
1
2021
Statut:
ppublish
Résumé
In multiple sclerosis (MS), a chronic demyelinating disease of the central nervous system, neurodegeneration is detected early in the disease course and is associated with the long-term disability of patients. Neurodegeneration is linked to both inflammation and demyelination, but its exact cause remains unknown. This gap in knowledge contributes to the current lack of treatments for the neurodegenerative phase of MS. Here we ask if neurodegeneration in MS affects specific neuronal components and if it is the result of demyelination. Neuropathological examination of secondary progressive MS motor cortices revealed a selective vulnerability of inhibitory interneurons in MS. The generation of a rodent model of focal subpial cortical demyelination reproduces this selective neurodegeneration providing a new preclinical model for the study of neuroprotective treatments.
Identifiants
pubmed: 33449171
doi: 10.1007/s00401-020-02258-z
pii: 10.1007/s00401-020-02258-z
pmc: PMC7882577
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
415-429Subventions
Organisme : Medical Research Council
ID : MR/K014137/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P006213/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P016022/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S035915/1
Pays : United Kingdom
Références
Curr Opin Neurol. 1999 Jun;12(3):295-302
pubmed: 10499174
Cereb Cortex. 2017 Oct 1;27(10):5001-5013
pubmed: 28922832
J Neurosci. 2008 Feb 20;28(8):1824-32
pubmed: 18287499
Brain. 2011 Feb;134(Pt 2):534-41
pubmed: 21216828
eNeuro. 2018 Jan 29;5(1):
pubmed: 29383328
Immunity. 2020 Jan 14;52(1):167-182.e7
pubmed: 31883839
Biophys J. 1997 Jul;73(1):220-9
pubmed: 9199786
Ann Neurol. 2015 Jun;77(6):1007-26
pubmed: 25727254
Cell Rep. 2019 Jun 4;27(10):2799-2808.e3
pubmed: 31167127
Elife. 2019 Nov 19;8:
pubmed: 31742557
Brain Pathol. 2017 Nov;27(6):737-747
pubmed: 27706868
Science. 2014 Apr 18;344(6181):319-24
pubmed: 24744380
Ann Neurol. 2001 Sep;50(3):389-400
pubmed: 11558796
Mult Scler. 2003 Aug;9(4):323-31
pubmed: 12926836
Annu Rev Neurosci. 2020 Jul 8;43:1-30
pubmed: 31299170
Brain. 2013 Dec;136(Pt 12):3596-608
pubmed: 24176976
J Neuroinflammation. 2019 Dec 7;16(1):259
pubmed: 31810488
JAMA Neurol. 2015 Sep;72(9):1004-12
pubmed: 26192316
Trends Mol Med. 2014 Mar;20(3):179-87
pubmed: 24369898
J Neuropathol Exp Neurol. 2003 Jul;62(7):723-32
pubmed: 12901699
Elife. 2016 Jul 06;5:
pubmed: 27383052
Brain. 1999 Jan;122 ( Pt 1):17-26
pubmed: 10050891
Neuropathol Appl Neurobiol. 2018 Jun;44(4):377-390
pubmed: 28419506
Eur J Neurosci. 2006 May;23(10):2581-94
pubmed: 16817861
Ann Neurol. 2011 Mar;69(3):445-54
pubmed: 21446020
Cell Rep. 2020 Aug 11;32(6):107988
pubmed: 32783927
Brain Pathol. 2001 Jan;11(1):107-16
pubmed: 11145196
Acta Biomater. 2019 Oct 1;97:216-229
pubmed: 31425890
Nat Neurosci. 2018 Oct;21(10):1392-1403
pubmed: 30258239
Mult Scler. 2012 Apr;18(4):425-32
pubmed: 21965421
Brain. 2016 Jan;139(Pt 1):39-46
pubmed: 26667278
Ann Neurol. 2020 Sep;88(3):562-573
pubmed: 32418239
Mol Psychiatry. 2017 Jan;22(1):4-12
pubmed: 27646261
Sci Rep. 2017 Dec 4;7(1):16878
pubmed: 29203879
Brain. 2006 Aug;129(Pt 8):1972-83
pubmed: 16714315
Ann Neurol. 2002 Dec;52(6):755-61
pubmed: 12447929
Nat Protoc. 2013;8(7):1366-80
pubmed: 23787894
N Engl J Med. 2011 Dec 8;365(23):2188-97
pubmed: 22150037
Brain Pathol. 2020 May;30(3):641-652
pubmed: 31916298
J Physiol. 2017 Mar 15;595(6):2147-2160
pubmed: 28083896
Am J Pathol. 2000 Jul;157(1):267-76
pubmed: 10880396
Nature. 2019 Sep;573(7772):75-82
pubmed: 31316211
Brain. 2015 Sep;138(Pt 9):2584-95
pubmed: 26304151
Nat Rev Drug Discov. 2019 Dec;18(12):905-922
pubmed: 31399729
Ann Neurol. 2006 Mar;59(3):478-89
pubmed: 16392116
Brain. 2012 Oct;135(Pt 10):2952-61
pubmed: 23065788
Curr Biol. 2011 Mar 22;21(6):480-4
pubmed: 21376596
J Neurophysiol. 2002 Jul;88(1):2-12
pubmed: 12091528
eNeuro. 2018 Oct 16;5(5):
pubmed: 30406183
Front Neuroinform. 2014 Feb 21;8:16
pubmed: 24600389
Neuron. 2018 Aug 22;99(4):781-799.e10
pubmed: 30078578