Imaging Features to Predict Response to Olfactory Training in Post-Traumatic Olfactory Dysfunction.
Adult
Aged
Area Under Curve
Craniocerebral Trauma
/ complications
Female
Humans
Magnetic Resonance Imaging
/ methods
Male
Middle Aged
Olfaction Disorders
/ diagnostic imaging
Olfactory Bulb
/ diagnostic imaging
Predictive Value of Tests
Prognosis
Reference Values
Reproducibility of Results
Retrospective Studies
Sensitivity and Specificity
Sensory Thresholds
Signal Detection, Psychological
Treatment Outcome
Young Adult
Olfactory dysfunction
Sniffin' Sticks test
head-trauma
olfactory training
Journal
The Laryngoscope
ISSN: 1531-4995
Titre abrégé: Laryngoscope
Pays: United States
ID NLM: 8607378
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
revised:
04
12
2020
received:
29
09
2020
accepted:
03
01
2021
pubmed:
16
1
2021
medline:
29
6
2021
entrez:
15
1
2021
Statut:
ppublish
Résumé
Prognosis of post-traumatic olfactory dysfunction is poor, with medical treatment options showing limited success rates. Olfactory training (OT) has been introduced as a potential therapeutic option in olfactory dysfunction. We aimed to identify the imaging features that would predict a better response to OT and create an imaging-based prognostic scale. We retrospectively reviewed 52 patients that underwent OT at our center for post-traumatic olfactory dysfunction. Olfactory functions at the time of initial presentation and at completion of OT were evaluated using Sniffin' Sticks test and threshold discrimination identification (TDI) scores were calculated. Patients were divided into responders (ROT group: 16 cases) and non-responders (n-ROT group: 36 cases) to OT based on TDI score change (cut-off 5.5 point). Morphological measurements of olfactory fossa, olfactory bulb volume and signal abnormalities, olfactory nerve filia integrity, siderosis, encephalomalacic changes in olfactory cortex, and other cortical regions were reviewed. There was no significant difference between the two groups in terms of age, gender distribution, olfactory dysfunction duration, head-trauma severity, and initial TDI scores. A model incorporating five variables: cribriform plate fracture, olfactory fossa depth (cut-off: 4.9 mm), olfactory bulb encephalomalacia, olfactory bulb volume (cut-off: 27.1 mm We developed an imaging-based scoring system with good specificity that can be used as an adjunctive tool for patient counseling, and optimal selection of management options. 4 Laryngoscope, 131:E2243-E2250, 2021.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
E2243-E2250Informations de copyright
© 2021 The American Laryngological, Rhinological and Otological Society, Inc.
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