Curcumin and cardiovascular diseases: Focus on cellular targets and cascades.
Cardiovascular diseases
Curcumin
Molecular signaling
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
20
08
2020
revised:
18
12
2020
accepted:
26
12
2020
pubmed:
16
1
2021
medline:
20
7
2021
entrez:
15
1
2021
Statut:
ppublish
Résumé
Cardiovascular diseases (CVDs) are one of the leading causes of the most considerable mortality globally, and it has been tried to find the molecular mechanisms and design new drugs that triggered the molecular target. Curcumin is the main ingredient of Curcuma longa (turmeric) that has been used in traditional medicine for treating several diseases for years. Numerous investigations have indicated the beneficial effect of Curcumin in modulating multiple signaling pathways involved in oxidative stress, inflammation, apoptosis, and proliferation. The cardiovascular protective effects of Curcumin against CVDs have been indicated in several studies. In the current review study, we provided novel information on Curcumin's protective effects against various CVDs and potential molecular signaling targets of Curcumin. Nonetheless, more studies should be performed to discover the exact molecular target of Curcumin against CVDs.
Identifiants
pubmed: 33450488
pii: S0753-3322(20)31407-4
doi: 10.1016/j.biopha.2020.111214
pii:
doi:
Substances chimiques
Cardiovascular Agents
0
Curcumin
IT942ZTH98
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111214Informations de copyright
Copyright © 2020. Published by Elsevier Masson SAS.