Vincamine, a safe natural alkaloid, represents a novel anticancer agent.
A549 Cells
Alkaloids
/ chemistry
Antineoplastic Agents
/ chemistry
Apoptosis
/ drug effects
Binding Sites
Caspase 3
/ chemistry
Caspase Inhibitors
/ pharmacology
Catalytic Domain
Cell Survival
/ drug effects
Humans
Kinetics
Membrane Potential, Mitochondrial
/ drug effects
Molecular Docking Simulation
Reactive Oxygen Species
/ metabolism
Thermodynamics
Vincamine
/ chemistry
Alkaloid
Caspase-3
Lung cancer
ROS
Vincamine
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
06
08
2020
revised:
30
12
2020
accepted:
31
12
2020
pubmed:
16
1
2021
medline:
9
9
2021
entrez:
15
1
2021
Statut:
ppublish
Résumé
Vincamine, a well-known plant alkaloid, has been used as a dietary supplement and as a peripheral vasodilator to combat aging in humans. In this study, for the very first time, we demonstrated that vincamine can function as an anticancer agent in a human alveolar basal epithelial cell line A549 (IC
Identifiants
pubmed: 33450545
pii: S0045-2068(21)00002-X
doi: 10.1016/j.bioorg.2021.104626
pii:
doi:
Substances chimiques
Alkaloids
0
Antineoplastic Agents
0
Caspase Inhibitors
0
Reactive Oxygen Species
0
Vincamine
996XVD0JHT
Caspase 3
EC 3.4.22.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104626Informations de copyright
Copyright © 2021. Published by Elsevier Inc.