Design, Synthesis and Biological Evaluation of Arylpyridin-2-yl Guanidine Derivatives and Cyclic Mimetics as Novel MSK1 Inhibitors. An Application in an Asthma Model.
MSK1
Pyridine-2-yl guanidine
asthma
inflammation
kinase inhibitors
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
13 Jan 2021
13 Jan 2021
Historique:
received:
03
12
2020
revised:
08
01
2021
accepted:
11
01
2021
entrez:
16
1
2021
pubmed:
17
1
2021
medline:
8
9
2021
Statut:
epublish
Résumé
Mitogen- and Stress-Activated Kinase 1 (MSK1) is a nuclear kinase, taking part in the activation pathway of the pro-inflammatory transcription factor NF-kB and is demonstrating a therapeutic target potential in inflammatory diseases such as asthma, psoriasis and atherosclerosis. To date, few MSK1 inhibitors were reported. In order to identify new MSK1 inhibitors, a screening of a library of low molecular weight compounds was performed, and the results highlighted the 6-phenylpyridin-2-yl guanidine (compound
Identifiants
pubmed: 33450992
pii: molecules26020391
doi: 10.3390/molecules26020391
pmc: PMC7828447
pii:
doi:
Substances chimiques
Guanidines
0
Protein Kinase Inhibitors
0
Ribosomal Protein S6 Kinases, 90-kDa
EC 2.7.11.1
mitogen and stress-activated protein kinase 1
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Association Vaincre la Mucoviscidose
ID : PRTP13/10 2010, RF20140501176, RF2016051629, RF2016052094
Organisme : Laboratory of Excellence Medalis, Initiative of Excellence (IdEx), Strasbourg University, France
ID : NA
Références
Clin Exp Immunol. 2014 Apr;176(1):1-10
pubmed: 24313320
J Invest Dermatol. 2007 Jun;127(6):1326-36
pubmed: 17255956
J Immunol. 2008 Mar 15;180(6):4256-64
pubmed: 18322238
PLoS One. 2012;7(11):e49512
pubmed: 23189147
EMBO J. 2003 Mar 17;22(6):1313-24
pubmed: 12628924
Biochem J. 2012 Jan 1;441(1):347-57
pubmed: 21970321
Int J Mol Sci. 2017 Oct 17;18(10):
pubmed: 29039777
J Biomol Screen. 1999;4(2):67-73
pubmed: 10838414
ChemMedChem. 2011 Feb 7;6(2):302-8
pubmed: 21275054
J Med Chem. 1980 Nov;23(11):1261-4
pubmed: 7452680
Eur J Med Chem. 2018 Mar 10;147:163-182
pubmed: 29432948
EMBO J. 1998 Aug 3;17(15):4426-41
pubmed: 9687510
J Nutr Biochem. 2008 Aug;19(8):536-44
pubmed: 18155512
Bioorg Med Chem Lett. 2017 Nov 15;27(22):5002-5005
pubmed: 29050783
ACS Med Chem Lett. 2010 Dec 29;2(2):107-12
pubmed: 24900288
J Org Chem. 2011 Nov 18;76(22):9216-27
pubmed: 21977964
Front Cell Dev Biol. 2016 Jun 10;4:56
pubmed: 27376065
Cells. 2019 Jul 05;8(7):
pubmed: 31284537
Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L326-39
pubmed: 19465513
Chemistry. 2004 May 17;10(10):2487-506
pubmed: 15146522
J Med Chem. 2007 May 31;50(11):2647-54
pubmed: 17480064
Neurosurgery. 2005 Feb;56(2):214-23; discussion 214-23
pubmed: 15670369
Angew Chem Int Ed Engl. 2000 Jan;39(1):165-168
pubmed: 10649362
J Cell Biochem. 2006 Aug 1;98(5):1095-105
pubmed: 16479592
Org Lett. 2019 Feb 1;21(3):683-686
pubmed: 30633536
J Biol Chem. 2003 Jun 27;278(26):23243-50
pubmed: 12690113
J Med Chem. 2009 Jul 23;52(14):4454-65
pubmed: 19527033
J Biol Chem. 2004 Jul 16;279(29):30474-9
pubmed: 15133024
FEBS Lett. 2000 Sep 29;482(1-2):44-8
pubmed: 11018520
Acta Neurochir (Wien). 1999;141(1):13-9
pubmed: 10071681
J Biol Chem. 2001 Jul 6;276(27):25184-9
pubmed: 11335727
Nat Commun. 2015 Jul 17;6:7796
pubmed: 26183376
Biochem Pharmacol. 2009 Apr 1;77(7):1194-205
pubmed: 19150610
Am J Physiol Lung Cell Mol Physiol. 2009 May;296(5):L804-10
pubmed: 19251839
Cell Mol Life Sci. 2009 Apr;66(7):1163-77
pubmed: 19011754
J Biol Chem. 2009 Sep 25;284(39):26368-76
pubmed: 19633291
EMBO J. 2002 Sep 16;21(18):4831-40
pubmed: 12234923
J Biol Chem. 2010 Aug 20;285(34):25928-40
pubmed: 20547488
Cardiovasc Res. 2010 May 1;86(2):211-8
pubmed: 20202975
ACS Chem Neurosci. 2018 Jun 20;9(6):1357-1365
pubmed: 29566331
Biochem J. 2000 Oct 1;351(Pt 1):95-105
pubmed: 10998351
J Immunol. 2000 Mar 15;164(6):3018-25
pubmed: 10706690
PLoS One. 2009;4(2):e4393
pubmed: 19197368