Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms.
ARNTL Transcription Factors
/ deficiency
Animals
Basic-Leucine Zipper Transcription Factors
/ genetics
Circadian Clocks
/ genetics
Circadian Rhythm
/ genetics
Cryptochromes
/ deficiency
DNA-Binding Proteins
/ genetics
Feeding Behavior
/ physiology
Gene Expression Regulation
Liver
/ metabolism
Male
Metabolic Networks and Pathways
/ genetics
Mice
Mice, Knockout
RNA, Messenger
/ genetics
Transcription Factors
/ genetics
Transcriptome
circadian clock
differential rhythmicity analysis
feeding–fasting cycle
liver metabolism
transcriptomics
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
19 01 2021
19 01 2021
Historique:
entrez:
16
1
2021
pubmed:
17
1
2021
medline:
13
5
2021
Statut:
ppublish
Résumé
The circadian clock and feeding rhythms are both important regulators of rhythmic gene expression in the liver. To further dissect the respective contributions of feeding and the clock, we analyzed differential rhythmicity of liver tissue samples across several conditions. We developed a statistical method tailored to compare rhythmic liver messenger RNA (mRNA) expression in mouse knockout models of multiple clock genes, as well as PARbZip output transcription factors (
Identifiants
pubmed: 33452134
pii: 2015803118
doi: 10.1073/pnas.2015803118
pmc: PMC7826335
pii:
doi:
Substances chimiques
ARNTL Transcription Factors
0
Bmal1 protein, mouse
0
Basic-Leucine Zipper Transcription Factors
0
Cry1 protein, mouse
0
Cry2 protein, mouse
0
Cryptochromes
0
DNA-Binding Proteins
0
Dbp protein, mouse
0
Hlf protein, mouse
0
Nfil3 protein, mouse
0
RNA, Messenger
0
Tef protein, mouse
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2021 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
Competing interest statement: B.D.W., C.G., F.A., E.M, A.C., and F.G. were employees of Société des Produits Nestlé SA.
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