A risk marker of tribasic hemagglutinin cleavage site in influenza A (H9N2) virus.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
15 01 2021
15 01 2021
Historique:
received:
15
06
2020
accepted:
06
12
2020
entrez:
16
1
2021
pubmed:
17
1
2021
medline:
29
6
2021
Statut:
epublish
Résumé
Low pathogenic avian influenza A(H9N2) virus is endemic worldwide and continually recruit internal genes to generate human-infecting H5N1, H5N6, H7N9, and H10N8 influenza variants. Here we show that hemagglutinin cleavage sites (HACS) of H9N2 viruses tended to mutate towards hydrophilic via evolutionary transition, and the tribasic HACS were found at high prevalence in Asia and the Middle East. Our finding suggested that the tribasic H9N2 viruses increased the viral replication, stability, pathogenicity and transmission in chickens and the virulence of mice compared to the monobasic H9N2 viruses. Notably, the enlarged stem-loop structures of HACS in the RNA region were found in the increasing tribasic H9N2 viruses. The enlarged HACS RNA secondary structures of H9N2 viruses did not influence the viral replication but accelerated the frequency of nucleotide insertion in HACS. With the prevailing tendency of the tribasic H9N2 viruses, the tribasic HACS in H9N2 viruses should be paid more attention.
Identifiants
pubmed: 33452423
doi: 10.1038/s42003-020-01589-7
pii: 10.1038/s42003-020-01589-7
pmc: PMC7811019
doi:
Substances chimiques
Hemagglutinins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
71Références
Proc Natl Acad Sci U S A. 2000 May 23;97(11):6108-13
pubmed: 10801978
Algorithms Mol Biol. 2011 Nov 24;6:26
pubmed: 22115189
Mol Cell. 2020 May 21;78(4):779-784.e5
pubmed: 32362314
J Virol. 2013 Feb;87(3):1811-20
pubmed: 23192872
J Virol. 2014 Feb;88(3):1673-83
pubmed: 24257604
Lancet. 2013 Jun 1;381(9881):1926-32
pubmed: 23643111
PLoS One. 2012;7(6):e40118
pubmed: 22768236
Emerg Microbes Infect. 2013 Nov;2(11):e75
pubmed: 26038443
Cell Host Microbe. 2016 Dec 14;20(6):810-821
pubmed: 27916476
Sci Rep. 2018 Jun 20;8(1):9396
pubmed: 29925854
Clin Infect Dis. 2014 Jun;58(11):1644-6
pubmed: 24621952
Sci Rep. 2016 Dec 14;6:38892
pubmed: 27966593
Emerg Microbes Infect. 2017 Mar 8;6(3):e12
pubmed: 28270655
Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9713-5
pubmed: 9707539
Infect Genet Evol. 2019 Nov;75:103979
pubmed: 31351233
J Virol. 2018 Jan 2;92(2):
pubmed: 29070694
Cell. 1998 Oct 30;95(3):409-17
pubmed: 9814710
J Virol. 2017 Mar 29;91(8):
pubmed: 28148803
J Cell Biol. 1981 Jun;89(3):674-9
pubmed: 6265470
Protein Cell. 2015 Jan;6(1):18-25
pubmed: 25384439
J Virol. 1997 Oct;71(10):7579-85
pubmed: 9311838
Euro Surveill. 2014 Jun 26;19(25):
pubmed: 24993558
Nucleic Acids Res. 2013 Jan;41(2):1241-54
pubmed: 23221636
Bioinformatics. 2017 Aug 15;33(16):2431-2435
pubmed: 28383669
J Infect Dis. 2015 May 1;211(9):1399-407
pubmed: 25355942
Protein Cell. 2014 Nov;5(11):878-82
pubmed: 25109943
Prev Vet Med. 2018 Aug 1;156:22-27
pubmed: 29891142
Emerg Microbes Infect. 2016 Apr 20;5:e35
pubmed: 27094903
Emerg Microbes Infect. 2014 Dec;3(12):e88
pubmed: 26038507
Arch Virol. 2014 Nov;159(11):2861-76
pubmed: 24990416
J Virol. 2013 Mar;87(5):2963-8
pubmed: 23269805
J Virol. 2000 Oct;74(20):9372-80
pubmed: 11000205
Emerg Microbes Infect. 2017 Nov 29;6(11):e106
pubmed: 29184157
Arch Virol. 2015 Aug;160(8):2063-70
pubmed: 26081872
J Clin Microbiol. 2005 Nov;43(11):5760-7
pubmed: 16272514
J Virol. 2012 Jun;86(12):6924-31
pubmed: 22496231
Vet Res. 2020 Mar 31;51(1):48
pubmed: 32234073
PLoS One. 2018 Jul 3;13(7):e0199260
pubmed: 29969454
mBio. 2017 Feb 14;8(1):
pubmed: 28196963
Clin Infect Dis. 2014 Sep 1;59(5):748-50
pubmed: 24812294
Avian Pathol. 2003 Oct;32(5):551-60
pubmed: 14522712
Annu Rev Genet. 2000;34:499-531
pubmed: 11092837
Virol J. 2011 Feb 10;8:64
pubmed: 21310053
J Virol. 2007 Oct;81(19):10389-401
pubmed: 17652402