Application of DNA-Alkylating Pyrrole-Imidazole Polyamides for Cancer Treatment.


Journal

Chembiochem : a European journal of chemical biology
ISSN: 1439-7633
Titre abrégé: Chembiochem
Pays: Germany
ID NLM: 100937360

Informations de publication

Date de publication:
04 05 2021
Historique:
revised: 28 12 2020
received: 01 11 2020
pubmed: 17 1 2021
medline: 15 12 2021
entrez: 16 1 2021
Statut: ppublish

Résumé

Pyrrole-imidazole (PI) polyamides, which target specific DNA sequences, have been studied as a class of DNA minor-groove-binding molecules. To investigate the potential of compounds for cancer treatment, PI polyamides were conjugated with DNA-alkylating agents, such as seco-CBI and chlorambucil. DNA-alkylating PI polyamides have attracted attention because of their sequence-specific alkylating activities, which contribute to reducing the severe side effects of current DNA-damaging drugs. Many of these types of conjugates have been developed as new candidates for anticancer drugs. Herein, we review recent progress into research on DNA-alkylating PI polyamides and their sequence-specific action on targets associated with cancer development.

Identifiants

pubmed: 33453075
doi: 10.1002/cbic.202000752
doi:

Substances chimiques

Antineoplastic Agents, Alkylating 0
Imidazoles 0
KRAS protein, human 0
Nylons 0
Pyrroles 0
DNA 9007-49-2
Proto-Oncogene Proteins p21(ras) EC 3.6.5.2

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1538-1545

Subventions

Organisme : AMED
ID : JP18am0301005
Organisme : Basic Science and Platform Technology Program for Innovative Biological Medicine
ID : JP18am0101101
Organisme : Platform Project for Supporting Drug Discovery
Organisme : Life Science Research
ID : JP16H06356
Organisme : JSPS

Informations de copyright

© 2021 Wiley-VCH GmbH.

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Auteurs

Rina Maeda (R)

Graduate School of Advanced Integrated Studies in Human Survivability, Kyoto University, Sakyo-ku, Kyoto, 606-8306, Japan.

Toshikazu Bando (T)

Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto, 606-8502, Japan.

Hiroshi Sugiyama (H)

Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto, 606-8502, Japan.
Institute for Integrated Cell-Material Science (iCeMS), Kyoto University, Yoshida-Ushinomiyacho, Sakyo-ku, Kyoto, 606-8501, Japan.

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