Contributions of white and brown adipose tissues to the circadian regulation of energy metabolism.
BAT
WAT
adipokines
adipose tissue
circadian clocks
circadian rhythm
cytokines
energy metabolism
hormones
obesity
thermogenesis
Journal
Endocrinology
ISSN: 1945-7170
Titre abrégé: Endocrinology
Pays: United States
ID NLM: 0375040
Informations de publication
Date de publication:
01 03 2021
01 03 2021
Historique:
received:
23
11
2020
pubmed:
17
1
2021
medline:
11
9
2021
entrez:
16
1
2021
Statut:
ppublish
Résumé
The term energy metabolism comprises the entirety of chemical processes associated with uptake, conversion, storage, and breakdown of nutrients. All these must be tightly regulated in time and space to ensure metabolic homeostasis in an environment characterized by cycles such as the succession of day and night. Most organisms evolved endogenous circadian clocks to achieve this goal. In mammals, a ubiquitous network of cellular clocks is coordinated by a pacemaker residing in the hypothalamic suprachiasmatic nucleus. Adipocytes harbor their own circadian clocks, and large aspects of adipose physiology are regulated in a circadian manner through transcriptional regulation of clock-controlled genes. White adipose tissue (WAT) stores energy in the form of triglycerides at times of high energy levels that then serve as fuel in times of need. It also functions as an endocrine organ, releasing factors in a circadian manner to regulate food intake and energy turnover in other tissues. Brown adipose tissue (BAT) produces heat through nonshivering thermogenesis, a process also controlled by the circadian clock. We here review how WAT and BAT contribute to the circadian regulation of energy metabolism. We describe how adipose rhythms are regulated by the interplay of systemic signals and local clocks and summarize how adipose-originating circadian factors feed-back on metabolic homeostasis. The role of adipose tissue in the circadian control of metabolism becomes increasingly clear as circadian disruption leads to alterations in adipose tissue regulation, promoting obesity and its sequelae. Stabilizing adipose tissue rhythms, in turn, may help to combat disrupted energy homeostasis and obesity.
Identifiants
pubmed: 33453099
pii: 6102571
doi: 10.1210/endocr/bqab009
pmc: PMC7864004
pii:
doi:
Substances chimiques
Adipokines
0
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.
Références
Cell Metab. 2010 Nov 3;12(5):509-20
pubmed: 21035761
Acta Physiol (Oxf). 2011 May;202(1):21-8
pubmed: 21251239
J Clin Endocrinol Metab. 2012 Feb;97(2):E218-22
pubmed: 22090280
J Clin Endocrinol Metab. 1987 Apr;64(4):832-5
pubmed: 3546356
Obesity (Silver Spring). 2012 Jul;20(7):1527-9
pubmed: 22447290
J Clin Endocrinol Metab. 1996 Sep;81(9):3419-23
pubmed: 8784108
J Comp Neurol. 2006 Jul 20;497(3):326-49
pubmed: 16736474
Brain Res. 1989 Dec 18;504(2):297-300
pubmed: 2598031
Am J Physiol Endocrinol Metab. 2005 Dec;289(6):E1051-7
pubmed: 16046456
Diabetes Obes Metab. 2016 Apr;18(4):355-65
pubmed: 26662378
BMC Med Genomics. 2009 Feb 09;2:7
pubmed: 19203388
Science. 2018 Mar 16;359(6381):
pubmed: 29439024
J Neuroendocrinol. 2001 Nov;13(11):959-66
pubmed: 11737554
Nature. 2012 Mar 29;485(7396):62-8
pubmed: 22460951
Nature. 1999 Dec 9;402(6762):656-60
pubmed: 10604470
Cell Metab. 2012 Jun 6;15(6):848-60
pubmed: 22608008
Eur J Clin Invest. 2008 Jan;38(1):71-2
pubmed: 18173555
J Exp Biol. 2018 Mar 7;221(Pt Suppl 1):
pubmed: 29514879
Comp Biochem Physiol B. 1971 May 15;39(1):69-82
pubmed: 5570026
Science. 2000 Aug 11;289(5481):950-3
pubmed: 10937998
Mol Endocrinol. 2006 Aug;20(8):1715-27
pubmed: 16556735
Curr Biol. 2013 Mar 4;23(5):372-81
pubmed: 23434278
Cell Metab. 2013 May 7;17(5):790-7
pubmed: 23663742
Endocrinology. 2010 Jan;151(1):115-22
pubmed: 19887569
Exp Physiol. 2017 Dec 1;102(12):1584-1595
pubmed: 29113012
Obes Res. 1995 May;3(3):233-40
pubmed: 7627771
J Biol Chem. 2010 Nov 19;285(47):36401-9
pubmed: 20851878
Obes Surg. 2020 Apr;30(4):1392-1403
pubmed: 31781938
Nat Med. 2012 Dec;18(12):1768-77
pubmed: 23142819
Metabolism. 2010 Jan;59(1):93-9
pubmed: 19765775
Life Sci. 2018 Jan 1;192:173-182
pubmed: 29196049
Clin Endocrinol (Oxf). 2012 Nov;77(5):691-8
pubmed: 22182404
Cell Metab. 2009 Feb;9(2):203-9
pubmed: 19187776
Cell Metab. 2016 Jul 12;24(1):130-41
pubmed: 27411014
J Lipid Res. 2008 Sep;49(9):1894-903
pubmed: 18503031
PLoS Biol. 2009 Sep;7(9):e1000181
pubmed: 19721697
J Clin Endocrinol Metab. 2001 Sep;86(9):4193-7
pubmed: 11549649
Sci Rep. 2016 Aug 09;6:30796
pubmed: 27503800
Mol Cell Endocrinol. 2015 Jan 5;399:284-7
pubmed: 25448847
Cell Metab. 2016 Apr 12;23(4):602-9
pubmed: 26972823
J Biol Chem. 2011 Apr 15;286(15):12983-90
pubmed: 21317437
Endocrinology. 2005 Dec;146(12):5631-6
pubmed: 16166217
J Atheroscler Thromb. 2005;12(3):169-74
pubmed: 16020918
Obes Rev. 2011 Mar;12(3):167-88
pubmed: 20557470
J Clin Invest. 2000 Aug;106(4):473-81
pubmed: 10953022
Nat Med. 1995 Nov;1(11):1155-61
pubmed: 7584987
Diabetes. 1997 Dec;46(12):2119-23
pubmed: 9392508
J Diabetes Res. 2019 Jul 17;2019:4021623
pubmed: 31396538
FASEB J. 2016 Sep;30(9):3117-23
pubmed: 27256623
Biochem Biophys Res Commun. 2007 Jun 1;357(2):371-6
pubmed: 17433253
J Endocrinol Invest. 2016 Jun;39(6):607-15
pubmed: 26662574
Nature. 1979 Sep 6;281(5726):31-5
pubmed: 551265
PLoS Biol. 2020 Feb 10;18(2):e3000630
pubmed: 32040503
J Clin Invest. 2006 Jul;116(7):1983-93
pubmed: 16767221
Annu Rev Genet. 2000;34:533-562
pubmed: 11092838
Genes Dev. 2001 Apr 15;15(8):995-1006
pubmed: 11316793
Chronobiol Int. 1987;4(4):483-91
pubmed: 3325177
FEBS Lett. 2011 Jul 21;585(14):2217-22
pubmed: 21635892
Biophys J. 2014 Sep 16;107(6):1462-73
pubmed: 25229153
J Intern Med. 1999 Jun;245(6):621-5
pubmed: 10395191
Diabetes. 2011 May;60(5):1577-81
pubmed: 21411511
Biochem J. 2005 Mar 15;386(Pt 3):575-81
pubmed: 15500444
J Biol Chem. 2003 Sep 26;278(39):37672-80
pubmed: 12821652
Am J Physiol. 1996 Aug;271(2 Pt 1):E246-52
pubmed: 8770017
Nature. 2002 Jan 17;415(6869):339-43
pubmed: 11797013
J Clin Invest. 2003 Dec;112(12):1821-30
pubmed: 14679177
Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E1105-14
pubmed: 19706786
Front Endocrinol (Lausanne). 2020 Apr 21;11:222
pubmed: 32373072
Physiol Rep. 2016 May;4(10):
pubmed: 27230905
Biochem Biophys Res Commun. 2005 Sep 9;334(4):1092-101
pubmed: 16039994
Am J Physiol. 1997 Jul;273(1 Pt 1):E226-30
pubmed: 9252501
Endocrinology. 2014 Jan;155(1):133-42
pubmed: 24189141
Cell Rep. 2018 Mar 27;22(13):3521-3533
pubmed: 29590620
Am J Physiol Endocrinol Metab. 2015 Jan 1;308(1):E84-95
pubmed: 25389364
Endocrinology. 2016 Nov;157(11):4222-4233
pubmed: 27690690
Nature. 2013 Nov 21;503(7476):410-413
pubmed: 24162845
PLoS One. 2015 Apr 02;10(4):e0122570
pubmed: 25837425
FASEB J. 2012 Aug;26(8):3453-63
pubmed: 22611086
Mol Cell Biol. 2000 Jul;20(13):4773-81
pubmed: 10848603
J Clin Invest. 1995 May;95(5):2111-9
pubmed: 7738178
PLoS Genet. 2007 Apr 27;3(4):e64
pubmed: 17465682
J Clin Invest. 1995 May;95(5):2409-15
pubmed: 7738205
J Biol Chem. 2006 Jun 9;281(23):15837-44
pubmed: 16595669
Physiol Rev. 2004 Jan;84(1):277-359
pubmed: 14715917
Cell Metab. 2007 Jul;6(1):55-68
pubmed: 17618856
J Clin Invest. 1975 Dec;56(6):1499-1508
pubmed: 1202081
Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12071-6
pubmed: 16093318
Genes Dev. 2017 Feb 15;31(4):383-398
pubmed: 28275001
FEBS J. 2020 Aug;287(15):3141-3149
pubmed: 32255270
Aging Cell. 2011 Dec;10(6):996-1010
pubmed: 21895961
Diabetologia. 2019 Apr;62(4):704-716
pubmed: 30737520
J Clin Endocrinol Metab. 1998 Feb;83(2):626-31
pubmed: 9467584
Acta Physiol (Oxf). 2020 Jan;228(1):e13281
pubmed: 30980501
Cell Metab. 2018 Aug 7;28(2):207-216.e3
pubmed: 29909972
Vitam Horm. 2000;59:265-304
pubmed: 10714243
Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16219-24
pubmed: 25349387
Science. 2009 May 1;324(5927):651-4
pubmed: 19299583
Diabetologia. 2006 Aug;49(8):1909-14
pubmed: 16736128
Mol Cell. 1999 Oct;4(4):585-95
pubmed: 10549290
Diabetes. 2006 Apr;55(4):962-70
pubmed: 16567517
FEBS Lett. 2006 Jan 9;580(1):127-30
pubmed: 16343493
Diabetologia. 2006 Apr;49(4):744-7
pubmed: 16496121
Front Endocrinol (Lausanne). 2020 Jun 12;11:351
pubmed: 32595600
J Biol Chem. 2000 Dec 8;275(49):38486-93
pubmed: 10948207
Cell Metab. 2016 Mar 8;23(3):441-53
pubmed: 26853749
Nature. 1979 Nov 29;282(5738):503-5
pubmed: 116135
J Physiol. 2019 Mar;597(6):1439-1450
pubmed: 30615204
Nat Med. 2011 Feb;17(2):200-5
pubmed: 21258337
J Nutr. 1997 Oct;127(10):2065-72
pubmed: 9311966
FEBS Lett. 2008 Oct 29;582(25-26):3639-42
pubmed: 18840432
Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20970-5
pubmed: 19091946
Endocrinology. 2001 Jun;142(6):2677-85
pubmed: 11356719
Diabetes. 1979 Nov;28(11):957-61
pubmed: 226442
Cell Metab. 2013 May 7;17(5):779-89
pubmed: 23663741
Proc Natl Acad Sci U S A. 2020 Feb 4;117(5):2484-2495
pubmed: 31964806
Diabetologia. 2014 May;57(5):1027-36
pubmed: 24531262
Handb Exp Pharmacol. 2013;(217):3-27
pubmed: 23604473
Cell Metab. 2015 Sep 1;22(3):448-59
pubmed: 26166747
Sci Rep. 2019 Feb 25;9(1):2641
pubmed: 30804433
Biochem Biophys Res Commun. 2003 Sep 19;309(2):286-90
pubmed: 12951047
PLoS One. 2011;6(10):e26223
pubmed: 22022575
Am J Physiol Cell Physiol. 2011 Jan;300(1):C198-209
pubmed: 20943959
Biochem Biophys Res Commun. 2009 Oct 30;388(4):654-9
pubmed: 19682428
J Clin Invest. 2014 Feb;124(2):515-27
pubmed: 24401271
Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):637-41
pubmed: 18396149
Cell Metab. 2016 Apr 12;23(4):610-21
pubmed: 27076076
Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2625-9
pubmed: 22308371
J Pharmacol Exp Ther. 1968 Jan;159(1):1-7
pubmed: 4384515
Science. 1990 Feb 23;247(4945):975-8
pubmed: 2305266
Mol Cell Biol. 2013 Sep;33(18):3659-66
pubmed: 23858058
J Lipid Res. 1994 Sep;35(9):1535-41
pubmed: 7806967
Diabetes. 2013 Jul;62(7):2195-203
pubmed: 23434933
Nat Med. 1995 Dec;1(12):1311-4
pubmed: 7489415
Commun Biol. 2019 Aug 8;2:300
pubmed: 31428688
Klin Wochenschr. 1961 Mar 15;39:293-8
pubmed: 13783942
Mol Cell. 1999 Oct;4(4):611-7
pubmed: 10549292
Nat Med. 2001 Aug;7(8):947-53
pubmed: 11479628
Pflugers Arch. 2006 Jun;452(3):260-7
pubmed: 16404608
Cell. 2006 Aug 25;126(4):801-10
pubmed: 16923398
Neuropeptides. 2017 Oct;65:1-9
pubmed: 28606559
Nat Rev Genet. 2017 Mar;18(3):164-179
pubmed: 27990019
Cell Metab. 2018 Jan 9;27(1):68-83
pubmed: 29320711
Trends Cell Biol. 2014 Feb;24(2):90-9
pubmed: 23916625
Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):2005-10
pubmed: 11172066
Life Sci. 2011 Mar 28;88(13-14):613-8
pubmed: 21295043
Methods Enzymol. 2015;552:125-43
pubmed: 25707275
Am J Physiol Cell Physiol. 2002 Jul;283(1):C244-50
pubmed: 12055093
Nat Med. 2001 Aug;7(8):941-6
pubmed: 11479627
Mol Cell Biol. 2010 Nov;30(21):5009-20
pubmed: 20733001
Nucleic Acids Res. 2007;35(2):648-55
pubmed: 17182630
Diabetologia. 1995 Jul;38(7):764-71
pubmed: 7556976
Compr Physiol. 2017 Dec 12;8(1):1-8
pubmed: 29357123
Diabetologia. 2011 May;54(5):1200-11
pubmed: 21298414
PLoS Biol. 2004 Nov;2(11):e377
pubmed: 15523558
Nature. 2000 Oct 19;407(6806):908-13
pubmed: 11057670
J Endocrinol. 2005 Jun;185(3):R1-8
pubmed: 15930160
Annu Rev Physiol. 2010;72:517-49
pubmed: 20148687
Aging (Albany NY). 2014 Dec;6(12):1019-32
pubmed: 25543537
J Clin Invest. 1993 Nov;92(5):2191-8
pubmed: 8227334
J Biol Chem. 1998 Sep 25;273(39):25420-6
pubmed: 9738010
Int J Obes (Lond). 2019 Aug;43(8):1644-1649
pubmed: 30232416
Cell Metab. 2017 Apr 4;25(4):935-944.e4
pubmed: 28380381
Chronobiol Int. 2009 Oct;26(7):1340-54
pubmed: 19916835
Cell Rep. 2015 Nov 24;13(8):1521-7
pubmed: 26586424
Cell Metab. 2006 Aug;4(2):163-73
pubmed: 16890544
Diabetes. 1997 Jul;46(7):1235-8
pubmed: 9200662
Cell Rep. 2020 Jan 21;30(3):672-686.e8
pubmed: 31968245
Stem Cells Int. 2016;2016:6067349
pubmed: 27073398
Cell Tissue Res. 2010 Jul;341(1):1-11
pubmed: 20563601
Am J Physiol Endocrinol Metab. 2012 Nov 1;303(9):E1126-33
pubmed: 22949029
Diabetes. 2003 Sep;52(9):2266-73
pubmed: 12941765
Elife. 2020 Jul 09;9:
pubmed: 32644041
Sci Rep. 2020 Oct 15;10(1):16888
pubmed: 33060645
Nature. 2001 May 24;411(6836):480-4
pubmed: 11373681
Physiol Res. 2010;59(4):615-618
pubmed: 19929131
J Biol Chem. 1994 Jan 28;269(4):2516-20
pubmed: 8300578
Front Neurosci. 2013 Feb 26;7:20
pubmed: 23550218
J Nutr Biochem. 2013 Jan;24(1):156-62
pubmed: 22898571
J Biol Chem. 2003 Mar 7;278(10):8401-6
pubmed: 12477720
Nature. 2001 Jan 11;409(6817):194-8
pubmed: 11196643
J Clin Invest. 2003 Dec;112(12):1796-808
pubmed: 14679176
Eur Rev Med Pharmacol Sci. 2011 Jan;15(1):9-14
pubmed: 21381495
Clin Endocrinol (Oxf). 2011 Oct;75(4):514-9
pubmed: 21521350
J Clin Endocrinol Metab. 2004 Jun;89(6):2548-56
pubmed: 15181022
Sci Rep. 2015 Nov 18;5:16748
pubmed: 26576661
Genes Cells. 2020 Apr;25(4):232-241
pubmed: 31991027
J Biol Chem. 1998 Sep 18;273(38):24665-9
pubmed: 9733764
Diabetes. 2000 Oct;49(10):1700-8
pubmed: 11016454
Science. 1995 Jul 28;269(5223):546-9
pubmed: 7624778
Diabetologia. 2013 May;56(5):949-64
pubmed: 23443243
Genes Dev. 2012 Feb 1;26(3):271-81
pubmed: 22302939
Nature. 2001 Jan 18;409(6818):307-12
pubmed: 11201732
Kobe J Med Sci. 2007;53(3):99-106
pubmed: 17684441