The molecular features of normal and atopic dermatitis skin in infants, children, adolescents, and adults.

Adolescent Adult Biomarkers / metabolism Child Cytokines / immunology Dermatitis, Atopic / immunology Eczema / immunology Female Filaggrin Proteins Humans Infant Inflammation / immunology Male Severity of Illness Index Skin / immunology Th2 Cells / immunology Young Adult
Atopic dermatitis T(H)2 T(H)22 biomarkers epidermal barrier maturation normal skin pediatric

Journal

The Journal of allergy and clinical immunology
ISSN: 1097-6825
Titre abrégé: J Allergy Clin Immunol
Pays: United States
ID NLM: 1275002

Informations de publication

Date de publication:
07 2021
Historique:
received: 23 06 2020
revised: 01 12 2020
accepted: 05 01 2021
pubmed: 17 1 2021
medline: 13 10 2021
entrez: 16 1 2021
Statut: ppublish

Résumé

Although atopic dermatitis (AD) often presents in infancy and persists into adulthood, comparative characterization of AD skin among different pediatric age groups is lacking. We sought to define skin biopsy profiles of lesional and nonlesional AD across different age groups (0-5-year-old infants with disease duration <6 months, 6-11-year-old children, 12-17-year-old adolescents, ≥18-year-old adults) versus age-appropriate controls. We performed gene expression analyses by RNA-sequencing and real-time PCR (RT-PCR) and protein expression analysis using immunohistochemistry. T The shared signature of AD across ages is T

Sections du résumé

BACKGROUND
Although atopic dermatitis (AD) often presents in infancy and persists into adulthood, comparative characterization of AD skin among different pediatric age groups is lacking.
OBJECTIVE
We sought to define skin biopsy profiles of lesional and nonlesional AD across different age groups (0-5-year-old infants with disease duration <6 months, 6-11-year-old children, 12-17-year-old adolescents, ≥18-year-old adults) versus age-appropriate controls.
METHODS
We performed gene expression analyses by RNA-sequencing and real-time PCR (RT-PCR) and protein expression analysis using immunohistochemistry.
RESULTS
T
CONCLUSIONS
The shared signature of AD across ages is T

Identifiants

DOI: 10.1016/j.jaci.2021.01.001 PMID: 33453290 PMC: PMC9285652
pubmed: 33453290
pii: S0091-6749(21)00007-5
doi: 10.1016/j.jaci.2021.01.001
pmc: PMC9285652
mid: NIHMS1814529
pii:
doi:

Substances chimiques

Biomarkers 0
Cytokines 0
FLG protein, human 0
Filaggrin Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

148-163

Subventions

Organisme : NIAMS NIH HHS
ID : P30 AR075049
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001866
Pays : United States

Informations de copyright

Copyright © 2021 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Références

Rocz Akad Med Bialymst. 2003;48:123-7
pubmed: 14737957
J Biol Chem. 2005 Apr 15;280(15):14755-64
pubmed: 15671038
J Am Acad Dermatol. 2018 May;78(5):863-871.e11
pubmed: 29353026
Curr Top Microbiol Immunol. 2017;410:29-45
pubmed: 28929191
Tissue Barriers. 2018;6(3):1539596
pubmed: 30395792
J Allergy Clin Immunol. 2013 Jan;131(1):187-200.e1-8
pubmed: 23006545
Science. 2010 Dec 17;330(6011):1695-9
pubmed: 21164017
J Allergy Clin Immunol. 2011 Apr;127(4):954-64.e1-4
pubmed: 21388663
Nat Immunol. 2004 Jul;5(7):752-60
pubmed: 15184896
Mucosal Immunol. 2017 Nov;10(6):1491-1503
pubmed: 28224996
Immunity. 2006 Aug;25(2):213-24
pubmed: 16919488
Lung. 2017 Dec;195(6):749-757
pubmed: 28993876
Br J Dermatol. 2020 Jan;182(1):85-96
pubmed: 31595499
Front Physiol. 2019 Dec 17;10:1514
pubmed: 31920718
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Oct;1862(10 Pt B):1197-1204
pubmed: 28648584
J Allergy Clin Immunol. 2014 Aug;134(2):362-72
pubmed: 24768652
Annu Rev Med. 2000;51:245-70
pubmed: 10774463
J Allergy Clin Immunol. 2020 Jan;145(1):215-228
pubmed: 31626841
J Dermatol Sci. 2013 Jun;70(3):204-10
pubmed: 23473858
Clin Mol Allergy. 2017 Dec 14;15:21
pubmed: 29259496
J Allergy Clin Immunol. 2019 Jan;143(1):135-141
pubmed: 29906525
J Allergy Clin Immunol. 2009 Jun;123(6):1244-52.e2
pubmed: 19439349
J Allergy Clin Immunol. 2015 Jan;135(1):153-63
pubmed: 25567045
J Allergy Clin Immunol. 2018 Oct;142(4):1121-1130.e7
pubmed: 29753033
Allergy. 2010 Sep;65(9):1166-72
pubmed: 20374230
J Invest Dermatol. 2018 Nov;138(11):2295-2300.e1
pubmed: 30348333
J Allergy Clin Immunol. 2019 Mar;143(3):894-913
pubmed: 30639346
JAMA Dermatol. 2020 Jan 1;156(1):44-56
pubmed: 31693077
J Am Coll Surg. 2012 Oct;215(4):503-11
pubmed: 22789546
J Invest Dermatol. 2018 Jul;138(7):1555-1563
pubmed: 29474945
J Allergy Clin Immunol. 2016 Dec;138(6):1639-1651
pubmed: 27671162
Clin Immunol. 2008 Mar;126(3):332-7
pubmed: 18166499
BMC Med Genomics. 2015 Oct 12;8:60
pubmed: 26459294
J Allergy Clin Immunol. 2014 Oct;134(4):769-79
pubmed: 25282559
JAMA Dermatol. 2019 Dec 1;155(12):1358-1370
pubmed: 31596431
Dermatol Clin. 2019 Apr;37(2):205-213
pubmed: 30850043
Curr Opin Allergy Clin Immunol. 2018 Aug;18(4):356-364
pubmed: 29870461
Clin Exp Immunol. 2005 Sep;141(3):459-66
pubmed: 16045735
J Allergy Clin Immunol. 2012 Feb;129(2):426-33, 433.e1-8
pubmed: 22177328
Proc Biol Sci. 2015 Dec 22;282(1821):20143085
pubmed: 26702035
J Allergy Clin Immunol. 1998 Oct;102(4 Pt 1):645-50
pubmed: 9802374
Semin Cell Dev Biol. 2017 Feb;62:170-177
pubmed: 27637160
J Allergy Clin Immunol. 2019 Jul;144(1):144-156
pubmed: 30685456
J Allergy Clin Immunol. 2011 Sep;128(3):583-93.e1-4
pubmed: 21762976
Ann Allergy Asthma Immunol. 2018 Jan;120(1):34-41
pubmed: 29126710
J Invest Dermatol. 2018 Jul;138(7):1467-1469
pubmed: 29941097
J Hum Genet. 2020 Apr;65(4):397-410
pubmed: 31911611
J Dermatol. 2019 Oct;46(10):825-834
pubmed: 31436343
Exp Dermatol. 2017 Apr;26(4):352-358
pubmed: 27943452
Front Immunol. 2020 Jul 28;11:1640
pubmed: 32849561
Exp Gerontol. 2001 Mar;36(3):547-57
pubmed: 11250125
J Allergy Clin Immunol. 2014 Dec;134(6):1329-1338.e10
pubmed: 25112699
J Allergy Clin Immunol. 2018 Jun;141(6):2094-2106
pubmed: 29731129
J Allergy Clin Immunol. 2018 Sep;142(3):844-856
pubmed: 29155150
Biomed Pharmacother. 2020 Feb;122:109705
pubmed: 31918276
J Immunol Res. 2015;2015:328146
pubmed: 26146640
J Allergy Clin Immunol. 2019 Jan;143(1):155-172
pubmed: 30194992
Br J Dermatol. 2018 May;178(5):1083-1101
pubmed: 29193016
J Allergy Clin Immunol. 2012 Dec;130(6):1344-54
pubmed: 22951056
N Engl J Med. 2014 Jul 10;371(2):130-9
pubmed: 25006719
J Dermatol. 2016 Oct;43(10):1117-1145
pubmed: 27076388
J Allergy Clin Immunol. 2016 Jan;137(1):301-304
pubmed: 26607705
Lancet. 2015 Feb 26;385 Suppl 1:S59
pubmed: 26312881
J Immunol. 2017 Jul 15;199(2):707-717
pubmed: 28615416
J Allergy Clin Immunol Pract. 2014 Jul-Aug;2(4):371-9; quiz 380-1
pubmed: 25017523
Semin Cutan Med Surg. 2012 Sep;31(3 Suppl):S6-9
pubmed: 23021784
J Exp Med. 2005 Nov 7;202(9):1213-23
pubmed: 16275760
J Dermatol. 2019 Aug;46(8):662-671
pubmed: 31166620
Expert Opin Pharmacother. 2019 Apr;20(5):621-629
pubmed: 30601075
Nat Commun. 2015 Feb 19;6:6329
pubmed: 25695838
Iran J Allergy Asthma Immunol. 2016 Apr;15(2):138-44
pubmed: 27090367
J Allergy Clin Immunol. 2006 Feb;117(2):411-7
pubmed: 16461142
Dermatol Clin. 2017 Jul;35(3):283-289
pubmed: 28577797
Immunol Rev. 2018 Jan;281(1):154-168
pubmed: 29247993
J Allergy Clin Immunol. 2009 May;123(5):977-83; quiz 984-5
pubmed: 19410687
J Immunol. 2007 Jun 1;178(11):6912-22
pubmed: 17513740
Nat Immunol. 2018 Jun;19(6):547-560
pubmed: 29777223
Mol Immunol. 2015 Jan;63(1):80-5
pubmed: 25017307
J Immunol. 2012 Oct 15;189(8):4079-87
pubmed: 22972927
Cutis. 2015 Dec;96(6):359-61
pubmed: 26761930
Ann Allergy Asthma Immunol. 2009 Aug;103(2):160-5
pubmed: 19739430
J Exp Med. 2006 May 15;203(5):1161-71
pubmed: 16618793
Pediatr Allergy Immunol. 2008 Nov;19(7):605-13
pubmed: 18266834
Eur J Immunol. 2012 Feb;42(2):311-9
pubmed: 22101893
Allergol Int. 2013 Jun;62(2):151-61
pubmed: 23712284
J Invest Dermatol. 2017 Oct;137(10):2110-2119
pubmed: 28595996
Iran J Allergy Asthma Immunol. 2014 Feb;13(1):11-8
pubmed: 24338223
Ann Allergy Asthma Immunol. 2019 Jan;122(1):99-110.e6
pubmed: 30223113
J Allergy Clin Immunol. 2015 Nov;136(5):1277-87
pubmed: 26316095
Genome Med. 2016 Dec 13;8(1):129
pubmed: 27964755
J Dermatol Sci. 2014 Jun;74(3):229-35
pubmed: 24667097
Allergy. 2020 Jul;75(7):1606-1617
pubmed: 31975538
J Allergy Clin Immunol. 2011 Mar;127(3):773-86.e1-7
pubmed: 21163515

Auteurs

Yael Renert-Yuval (Y)

Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY; Department of Dermatology and Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY.

Ester Del Duca (E)

Department of Dermatology and Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Dermatology, University Magna Graecia, Catanzaro, Italy.

Ana B Pavel (AB)

Department of Dermatology and Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Biomedical Engineering, University of Mississippi, Oxford, Miss.

Milie Fang (M)

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Ill.

Rachel Lefferdink (R)

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Ill.

Jianni Wu (J)

Department of Dermatology and Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY.

Aisleen Diaz (A)

Department of Dermatology and Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY.

Yeriel D Estrada (YD)

Department of Dermatology and Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY.

Talia Canter (T)

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Ill.

Ning Zhang (N)

Department of Dermatology and Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY.

Annette Wagner (A)

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Ill.

Sarah Chamlin (S)

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Ill.

James G Krueger (JG)

Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY.

Emma Guttman-Yassky (E)

Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY; Department of Dermatology and Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: Emma.Guttman@mountsinai.org.

Amy S Paller (AS)

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Ill. Electronic address: apaller@northwestern.edu.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › The molecular features of normal and atopic...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › The molecular features of normal and atopic...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › The molecular features of normal and atopic...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › The molecular features of normal and atopic...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › The molecular features of normal and atopic...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Eczéma atopique › The molecular features of normal and atopic...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Dermatoses eczémateuses › Eczéma › The molecular features of normal and atopic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines S100 › Protéines filaggrine › The molecular features of normal and atopic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The molecular features of normal and atopic...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › The molecular features of normal and atopic...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › The molecular features of normal and atopic...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Indice de gravité de la maladie › The molecular features of normal and atopic...
questionsmedicales.fr › Système tégumentaire › Peau › The molecular features of normal and atopic...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Lymphocytes auxiliaires Th2 › The molecular features of normal and atopic...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › The molecular features of normal and atopic...