Ethical Principles, Constraints and Opportunities in Clinical Proteomics.
Journal
Molecular & cellular proteomics : MCP
ISSN: 1535-9484
Titre abrégé: Mol Cell Proteomics
Pays: United States
ID NLM: 101125647
Informations de publication
Date de publication:
14 Jan 2021
14 Jan 2021
Historique:
received:
18
12
2020
accepted:
04
01
2021
pubmed:
17
1
2021
medline:
17
1
2021
entrez:
16
1
2021
Statut:
aheadofprint
Résumé
Recent advances in mass spectrometry (MS)-based proteomics have vastly increased the quality and scope of biological information that can be derived from human samples. These advances have rendered current workflows increasingly applicable in biomedical and clinical contexts. As proteomics is poised to take an important role in the clinic, associated ethical responsibilities increase in tandem with impacts on the health, privacy, and wellbeing of individuals. We conducted and here report a systematic literature review of ethical issues in clinical proteomics. We add our perspectives from a background of bioethics, the results of our accompanying paper extracting individual-sensitive results from patient samples, and the literature addressing similar issues in genomics. The spectrum of potential issues ranges from patient re-identification to incidental findings of clinical significance. The latter can be divided into actionable and unactionable findings. Some of these have the potential to be employed in discriminatory or privacy-infringing ways. However, incidental findings may also have great positive potential. A plasma proteome profile, for instance, could inform on the general health or disease status of an individual regardless of the narrow diagnostic question that prompted it. We suggest that early discussion of ethical issues in clinical proteomics can ensure that eventual healthcare practices and regulations reflect the considered judgment of the community and anticipate opportunities and problems that may arise as the technology matures.
Identifiants
pubmed: 33453411
pii: S1535-9476(21)00001-3
doi: 10.1016/j.mcpro.2021.100046
pmc: PMC7950205
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
100046Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES017885
Pays : United States
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
Références
PeerJ. 2014 Aug 05;2:e506
pubmed: 25165623
J Law Med Ethics. 2020 Mar;48(1):142-150
pubmed: 32342776
BMC Med Res Methodol. 2008 Jul 10;8:45
pubmed: 18616818
Mol Cell Proteomics. 2021;20:100035
pubmed: 33444735
J Law Med Ethics. 2020 Mar;48(1):69-86
pubmed: 32342790
Philos Trans A Math Phys Eng Sci. 2016 Dec 28;374(2083):
pubmed: 28336803
J Health Econ. 2019 Dec;68:102242
pubmed: 31605834
New Genet Soc. 2016 Jan 2;35(1):49-68
pubmed: 27134568
Nat Rev Mol Cell Biol. 2019 May;20(5):285-302
pubmed: 30659282
J Adv Nurs. 2013 Jan;69(1):194-204
pubmed: 22591030
Mol Cell Proteomics. 2004 Jun;3(6):531-3
pubmed: 15075378
Comput Secur. 2020 Oct;97:101966
pubmed: 32834254
BMC Med Res Methodol. 2012 Nov 27;12:181
pubmed: 23185978
Eur J Hum Genet. 2019 Aug;27(8):1159-1167
pubmed: 30996335
Nat Biotechnol. 2014 Mar;32(3):223-6
pubmed: 24727771
J Neural Transm (Vienna). 2017 Jan;124(1):25-32
pubmed: 26645377
Biochim Biophys Acta. 2014 May;1844(5):899-908
pubmed: 24412545
Genome Biol. 2018 Feb 15;19(1):21
pubmed: 29448949
J Law Med Ethics. 2015 Fall;43(3):576-93
pubmed: 26479568
Genes (Basel). 2019 Sep 05;10(9):
pubmed: 31492022
Fla Law Rev. 2019 Sep;71(5):1281-1345
pubmed: 34305361
Nat Chem Biol. 2018 Feb 14;14(3):206-214
pubmed: 29443976
J Proteome Res. 2020 Dec 4;19(12):4735-4746
pubmed: 32931287
J Med Ethics. 2018 Jun;44(6):392-396
pubmed: 29358219
Expert Rev Proteomics. 2004 Jun;1(1):77-86
pubmed: 15966801
Mol Syst Biol. 2017 Sep 26;13(9):942
pubmed: 28951502
J Proteome Res. 2016 Nov 4;15(11):3961-3970
pubmed: 27490519
Open Med. 2009;3(3):e123-30
pubmed: 21603045
Syst Rev. 2016 May 04;5:74
pubmed: 27145932
Nurs Ethics. 2020 Jun;27(4):960-978
pubmed: 32238039
Annu Rev Public Health. 2016;37:375-94
pubmed: 26789384
Mol Syst Biol. 2016 Dec 22;12(12):901
pubmed: 28007936
Curr Protoc Hum Genet. 2015 Oct 06;87:9.23.1-9.23.16
pubmed: 26439717
Sci Data. 2016 Mar 15;3:160018
pubmed: 26978244
PLoS Biol. 2019 May 1;17(5):e3000246
pubmed: 31042704
Proteomics Clin Appl. 2010 Mar;4(3):250-70
pubmed: 21137047
Syst Rev. 2017 Dec 19;6(1):261
pubmed: 29258598
Eur J Hum Genet. 2013 Mar;21(3):248-55
pubmed: 22739341
Proteomics Clin Appl. 2019 Mar;13(2):e1800199
pubmed: 30706988
J Proteome Res. 2019 Dec 6;18(12):4108-4116
pubmed: 31599596
Front Psychol. 2016 Nov 25;7:1832
pubmed: 27933012
Mol Syst Biol. 2018 Aug 13;14(8):e8126
pubmed: 30104418
Nat Genet. 2019 Apr;51(4):584-591
pubmed: 30926966
AMIA Jt Summits Transl Sci Proc. 2016 Aug 31;2016:122-31
pubmed: 27595046
BMC Med. 2016 Oct 3;14(1):152
pubmed: 27716264
Eur J Hum Genet. 2020 Feb;28(2):147-154
pubmed: 31534213
Nat Biotechnol. 2017 Aug;35(8):747-756
pubmed: 28714965
Pathol Res Pract. 2004;200(2):179-80
pubmed: 15237927
Proteomics. 2004 Jul;4(7):1929-31
pubmed: 15221751
Hum Genet. 2019 Dec;138(11-12):1237-1246
pubmed: 31531740
Trends Biochem Sci. 2017 May;42(5):333-341
pubmed: 28118949
EMBO Rep. 2017 Mar;18(3):355-358
pubmed: 28219901
Proteomics. 2003 Aug;3(8):1387-96
pubmed: 12923763
Nat Hum Behav. 2017 Jan 10;1:0021
pubmed: 33954258
J Med Ethics. 2020 May 4;:
pubmed: 32366703
PLoS One. 2016 Sep 07;11(9):e0160653
pubmed: 27603779
Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):10820-10823
pubmed: 30352870
Mol Cell Proteomics. 2005 Apr;4(4):384-93
pubmed: 15695805
Hum Mutat. 2016 Dec;37(12):1248-1256
pubmed: 27647801
Genet Med. 2013 Nov;15(11):854-9
pubmed: 23907645
J Pain Symptom Manage. 2018 Jun;55(6):1577-1590
pubmed: 29382541
Nat Methods. 2013 Jan;10(1):19-22
pubmed: 23547293
BMC Med Res Methodol. 2020 Jan 13;20(1):7
pubmed: 31931747
Genome Med. 2019 Jul 25;11(1):46
pubmed: 31345272
Eur J Med Genet. 2019 Jun;62(6):103529
pubmed: 30165243
J Proteome Res. 2013 Dec 6;12(12):5383-94
pubmed: 24063748
Nature. 2016 Sep 14;537(7620):347-55
pubmed: 27629641
Cancer Prev Res (Phila). 2020 Mar;13(3):219-222
pubmed: 32132115
J Med Libr Assoc. 2018 Oct;106(4):531-541
pubmed: 30271302
Eur J Hum Genet. 2019 Apr;27(4):535-546
pubmed: 30622328
Proteomics. 2015 Feb;15(4):649-55
pubmed: 25404351
Eur J Hum Genet. 2018 Oct;26(10):1424-1431
pubmed: 29970927
EMBO Mol Med. 2019 Nov 7;11(11):e10427
pubmed: 31566909
Genet Med. 2017 Feb;19(2):249-255
pubmed: 27854360