Lassa-VSV chimeric virus targets and destroys human and mouse ovarian cancer by direct oncolytic action and by initiating an anti-tumor response.
Journal
Virology
ISSN: 1096-0341
Titre abrégé: Virology
Pays: United States
ID NLM: 0110674
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
07
08
2020
revised:
18
10
2020
accepted:
28
10
2020
pubmed:
17
1
2021
medline:
31
12
2021
entrez:
16
1
2021
Statut:
ppublish
Résumé
Ovarian cancer is the third most common female cancer, with poor survival in later stages of metastatic spread. We test a chimeric virus consisting of genes from Lassa and vesicular stomatitis viruses, LASV-VSV; the native VSV glycoprotein is replaced by the Lassa glycoprotein, greatly reducing neurotropism. Human ovarian cancer cells in immunocompromised nude mice were lethal in controls. Chemotherapeutic paclitaxel and cisplatin showed modest cancer inhibition and survival extension. In contrast, a single intraperitoneal injection of LASV-VSV selectively infected and killed ovarian cancer cells, generating long-term survival. Mice with human ovarian cancer cells in brain showed rapid deterioration; LASV-VSV microinjection into brain blocked cancer growth, and generated long-term survival. Treatment of immunocompetent mice with infected mouse ovarian cancer cells blocked growth of non-infected ovarian cancer cells peritoneally and in brain. These results suggest LASV-VSV is a viable candidate for further study and may be of use in the treatment of ovarian cancer.
Identifiants
pubmed: 33453650
pii: S0042-6822(20)30211-7
doi: 10.1016/j.virol.2020.10.009
pmc: PMC8451984
mid: NIHMS1713987
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
44-55Subventions
Organisme : NCI NIH HHS
ID : R01 CA188359
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA199004
Pays : United States
Informations de copyright
Copyright © 2020. Published by Elsevier Inc.
Références
Am J Reprod Immunol. 2012 Jan;67(1):84-90
pubmed: 21951577
J Virol. 2005 May;79(10):6005-22
pubmed: 15857987
J Neurooncol. 2004 Feb;66(3):313-25
pubmed: 15015663
Med Oncol. 2012 Jun;29(2):1250-2
pubmed: 21380785
Oncotarget. 2017 Jun 20;8(25):41143-41153
pubmed: 28467804
Cancer Sci. 2016 Oct;107(10):1373-1379
pubmed: 27486853
J Clin Oncol. 2009 Mar 20;27(9):1419-25
pubmed: 19224846
EMBO J. 2012 Apr 18;31(8):1947-60
pubmed: 22395071
Mol Ther Oncolytics. 2018 May 03;9:51-63
pubmed: 29988525
Gynecol Oncol. 2012 Oct;127(1):75-82
pubmed: 22750127
Gene Ther. 2003 Feb;10(4):292-303
pubmed: 12595888
Oncogene. 2015 Jul;34(27):3605-16
pubmed: 25263447
J Virol. 2013 Jan;87(2):1019-34
pubmed: 23135719
J Virol. 2002 Feb;76(3):1309-27
pubmed: 11773406
Mol Cancer Res. 2019 Apr;17(4):974-986
pubmed: 30587523
Anticancer Res. 2009 Jul;29(7):2793-8
pubmed: 19596963
J Virol. 2015 Jul;89(13):6711-24
pubmed: 25878115
Obstet Gynecol. 1986 Dec;68(6):746-50
pubmed: 3024084
Acta Obstet Gynecol Scand. 2016 Oct;95(10):1181-9
pubmed: 27454324
J Neurooncol. 2017 Jul;133(3):469-476
pubmed: 28497333
Endocrinology. 2015 Jun;156(6):1975-81
pubmed: 25815421
J Virol. 2010 Feb;84(3):1563-73
pubmed: 19906910
Curr Opin Obstet Gynecol. 2017 Feb;29(1):26-34
pubmed: 27898521
F1000Res. 2016 Aug 30;5:
pubmed: 27635234
Neuropathol Appl Neurobiol. 1987 Mar-Apr;13(2):111-22
pubmed: 3039392
Apoptosis. 2017 Apr;22(4):558-569
pubmed: 28012060
Nat Med. 2011 Oct 30;17(11):1498-503
pubmed: 22037646
Int J Gynecol Cancer. 2010 Dec;20(9):1511-7
pubmed: 21370594
Hum Gene Ther. 2011 Nov;22(11):1343-53
pubmed: 21366404
PLoS Negl Trop Dis. 2012;6(3):e1567
pubmed: 22448291
J Hematol Oncol. 2018 May 10;11(1):64
pubmed: 29747682
Cancer Gene Ther. 2009 Jan;16(1):44-52
pubmed: 18654610
Gynecol Oncol. 1993 Apr;49(1):37-40
pubmed: 8482558
Jpn J Clin Oncol. 2017 Jul 1;47(7):604-610
pubmed: 28398498
Cancer Gene Ther. 2013 Nov;20(11):616-21
pubmed: 24176894
Semin Cancer Biol. 2017 Jun;44:67-71
pubmed: 28450177
Gynecol Oncol. 2015 Mar;136(3):491-7
pubmed: 25455734
Cancer Med. 2013 Dec;2(6):751-62
pubmed: 24403249
J Virol. 2009 Jul;83(14):7296-304
pubmed: 19386702
J Virol. 2013 Jun;87(12):6644-59
pubmed: 23552414
Acta Obstet Gynecol Scand. 2008;87(12):1343-52
pubmed: 18951208
Mol Cancer Ther. 2016 Jun;15(6):1279-90
pubmed: 27196760
Clin Exp Immunol. 2019 Mar;195(3):334-344
pubmed: 30582756
J Virol. 2010 Jan;84(1):163-75
pubmed: 19846533
J Clin Endocrinol Metab. 1975 Mar;40(3):401-5
pubmed: 163842
Cancer Res. 2012 Apr 1;72(7):1651-60
pubmed: 22315352
In Vitro. 1970 Nov-Dec;6(3):205-14
pubmed: 5535575
Nihon Sanka Fujinka Gakkai Zasshi. 1985 Jul;37(7):1103-11
pubmed: 4031568
J Virol. 1993 Nov;67(11):6698-706
pubmed: 8105106
Science. 2013 Apr 26;340(6131):479-83
pubmed: 23519211
Oncotarget. 2019 Feb 22;10(16):1544-1545
pubmed: 30899421
J Immunother Cancer. 2019 Jul 17;7(1):189
pubmed: 31315674
Nat Med. 2000 Jul;6(7):821-5
pubmed: 10888934
PLoS Negl Trop Dis. 2015 Apr 17;9(4):e0003736
pubmed: 25884628
Mol Ther. 2014 Jun;22(6):1198-1210
pubmed: 24590047
PLoS Med. 2005 Jun;2(6):e183
pubmed: 15971954
J Korean Med Sci. 2015 Jan;30(1):66-73
pubmed: 25552885
Ann Oncol. 2017 Nov 1;28(suppl_8):viii61-viii65
pubmed: 29232466
J Natl Cancer Inst. 2018 Oct 1;110(10):1123-1132
pubmed: 29788332
Oncogene. 2014 Jul 10;33(28):3619-33
pubmed: 23934194
Ann Oncol. 2017 Nov 1;28(suppl_8):viii46-viii50
pubmed: 29232475
J Vis Exp. 2014 Nov 02;(93):e51815
pubmed: 25407815
Oncology (Williston Park). 2018 Aug 15;32(8):418-20, 422-4
pubmed: 30153322
J Virol. 2009 Nov;83(22):11540-9
pubmed: 19726512
Placenta. 2009 Nov;30(11):939-48
pubmed: 19766308
Cancer Res. 2007 Mar 15;67(6):2840-8
pubmed: 17363607
J Soc Gynecol Investig. 2004 Dec;11(8):553-61
pubmed: 15582501
Cancers (Basel). 2019 May 11;11(5):
pubmed: 31083559
Neurol India. 2019 Nov-Dec;67(6):1431-1436
pubmed: 31857529
Cell Cycle. 2009 Jan 1;8(1):158-66
pubmed: 19158483
J Virol. 2020 Mar 31;94(8):
pubmed: 32051271
Ann Oncol. 2016 Nov;27(11):2017-2025
pubmed: 27597548
Sci Rep. 2017 Jan 25;7:40989
pubmed: 28120873
PLoS One. 2015 Dec 04;10(12):e0144126
pubmed: 26637171
Hum Cell. 2002 Sep;15(3):104-17
pubmed: 12703541
Best Pract Res Clin Obstet Gynaecol. 2017 May;41:139-152
pubmed: 28111228
J Virol. 2005 Dec;79(24):15043-53
pubmed: 16306575
Am J Reprod Immunol. 2016 Apr;75(4):451-60
pubmed: 26892235
Cancer Gene Ther. 2012 Apr;19(4):282-91
pubmed: 22240921
Oncoimmunology. 2020 May 13;9(1):1758869
pubmed: 32566387
J Neurosci. 2008 Feb 20;28(8):1882-93
pubmed: 18287505
Recent Pat Anticancer Drug Discov. 2018;13(4):392-410
pubmed: 29512470
Cancer. 2017 Sep 15;123(18):3450-3459
pubmed: 28678350
J Neurooncol. 2014 Aug;119(1):1-6
pubmed: 24789253
Hematol Oncol Clin North Am. 2018 Dec;32(6):943-964
pubmed: 30390767
Anticancer Drugs. 2019 Nov;30(10):1064-1066
pubmed: 31567308
Best Pract Res Clin Obstet Gynaecol. 2017 May;41:3-14
pubmed: 27743768