Cognitive Control in Pediatric Obsessive-Compulsive and Anxiety Disorders: Brain-Behavioral Targets for Early Intervention.
Anxiety disorders
Cognitive control
Default mode network
OCD
Review
Task control circuits
Triple network model
Journal
Biological psychiatry
ISSN: 1873-2402
Titre abrégé: Biol Psychiatry
Pays: United States
ID NLM: 0213264
Informations de publication
Date de publication:
01 04 2021
01 04 2021
Historique:
received:
08
06
2020
revised:
19
10
2020
accepted:
03
11
2020
pubmed:
18
1
2021
medline:
24
4
2021
entrez:
17
1
2021
Statut:
ppublish
Résumé
The DSM provides distinct criteria for obsessive-compulsive disorder (OCD) and various types of anxiety disorders, but phenomenological overlap, high rates of comorbidity, and early onset suggest common underlying mechanisms. This notion is further supported by use of the same treatments-cognitive behavioral therapy and serotonin reuptake inhibitor medication-for managing both OCD and non-OCD anxiety disorders in clinical settings. While early intervention with these gold standard treatments is recommended for pediatric OCD and anxiety disorders, young patients often remain symptomatic even after treatment. To guide the development of novel, mechanistically targeted treatments to better resolve OCD and anxiety symptoms, the identification of neural circuits underlying psychological constructs with relevance across disorders has been recommended. One construct that may be relevant for understanding pediatric OCD and anxiety disorders is cognitive control, given the difficulty that young patients experience in dismissing obsessions, compulsions, and worry despite recognition that these symptoms are excessive and unreasonable. In this review, we examine findings from a growing body of literature implicating brain-behavioral markers of cognitive control in pediatric OCD and anxiety disorders, including before and after treatment. We conclude by suggesting that interventions designed to enhance the functioning of the task control circuits underlying cognitive control may facilitate brain maturation to help affected youth overcome symptoms.
Identifiants
pubmed: 33454049
pii: S0006-3223(20)32073-4
doi: 10.1016/j.biopsych.2020.11.012
pmc: PMC8353584
mid: NIHMS1724515
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
697-706Subventions
Organisme : NIMH NIH HHS
ID : R01 MH114958
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH115024
Pays : United States
Informations de copyright
Copyright © 2020. Published by Elsevier Inc.
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