Drug discovery for enzymes.

Drug Design / trends Drug Discovery / methods Enzyme Inhibitors / pharmacology Enzymes / metabolism Humans Molecular Targeted Therapy / trends

Journal

Drug discovery today
ISSN: 1878-5832
Titre abrégé: Drug Discov Today
Pays: England
ID NLM: 9604391

Informations de publication

Date de publication:
04 2021
Historique:
received: 25 09 2020
revised: 21 12 2020
accepted: 07 01 2021
pubmed: 18 1 2021
medline: 22 1 2022
entrez: 17 1 2021
Statut: ppublish

Résumé

Enzymes are essential, physiological catalysts involved in all processes of life, including metabolism, cellular signaling and motility, as well as cell growth and division. They are attractive drug targets because of the presence of defined substrate-binding pockets, which can be exploited as binding sites for pharmaceutical enzyme inhibitors. Understanding the reaction mechanisms of enzymes and the molecular mode of action of enzyme inhibitors is indispensable for the discovery and development of potent, efficacious, and safe novel drugs. The combination of classical concepts of enzymology with new experimental and data analysis methods opens new routes for drug discovery.

Identifiants

DOI: 10.1016/j.drudis.2021.01.006 PMID: 33454380
pubmed: 33454380
pii: S1359-6446(21)00006-4
doi: 10.1016/j.drudis.2021.01.006
pii:
doi:

Substances chimiques

Enzyme Inhibitors 0
Enzymes 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

875-886

Informations de copyright

Copyright © 2021 The Author. Published by Elsevier Ltd.. All rights reserved.

Auteurs

Arne Christian Rufer (AC)

Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 065/208A, 4070 Basel, Switzerland. Electronic address: arne.rufer@roche.com.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Drug discovery for enzymes.
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Drug discovery for enzymes.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Drug discovery for enzymes.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Drug discovery for enzymes.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Drug discovery for enzymes.
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Thérapie moléculaire ciblée › Drug discovery for enzymes.