Damage tolerance and toughness of elderly human femora.
Biomechanics
Bone fracture prevention
Elastic instability
Fracture risk assessment
Osteoporosis
Journal
Acta biomaterialia
ISSN: 1878-7568
Titre abrégé: Acta Biomater
Pays: England
ID NLM: 101233144
Informations de publication
Date de publication:
15 03 2021
15 03 2021
Historique:
received:
27
10
2020
revised:
22
12
2020
accepted:
09
01
2021
pubmed:
18
1
2021
medline:
20
5
2021
entrez:
17
1
2021
Statut:
ppublish
Résumé
Observations of elastic instability of trabecular bone cores supported the analysis of cortical thickness for predicting bone fragility of the hip in people over 60 years of age. Here, we falsified the hypothesis that elastic instability causes minimal energy fracture by analyzing, with a micrometric resolution, the deformation and fracture behavior of entire femora. Femur specimens were obtained from elderly women aged between 66 - 80 years. Microstructural images of the proximal femur were obtained under 3 - 5 progressively increased loading steps and after fracture. Bone displacements, strain, load bearing and energy absorption capacity were analyzed. Elastic instability of the cortex appeared at early loading stages in regions of peak compression. No elastic instability of trabecular bone was observed. The subchondral bone displayed local crushing in compression at early loading steps and progressed to 8 - 16% compression before fracture. The energy absorption capacity was proportional to the displacement. Stiffness decreased to near-zero values before fracture. Three-fourth of the fracture energy (10.2 - 20.2 J) was dissipated in the final 25% force increment. Fracture occurred in regions of peak tension and shear, adjacent to the location of peak compression, appearing immediately before fracture. Minimal permanent deformation was visible along the fracture surface. Elastic instability modulates the interaction between cortical and trabecular bone promoting an elastically stable fracture behavior of the femur organ, load bearing capacity, toughness, and damage tolerance. These findings will advance current methods for predicting hip fragility.
Identifiants
pubmed: 33454384
pii: S1742-7061(21)00029-5
doi: 10.1016/j.actbio.2021.01.011
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
167-177Subventions
Organisme : Medical Research Council
ID : MR/P020941/1
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Acta Materialia Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest Certara QSP provided the salary for MG during the writing of the manuscript but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. All the other authors declare no conflict of interest in relation to the present study.