TBK1 (TANK-binding kinase 1)-mediated regulation of autophagy in health and disease.
Autophagy
Cancer
Mitophagy
Neurodegeneration
TBK1
Xenophagy
Journal
Matrix biology : journal of the International Society for Matrix Biology
ISSN: 1569-1802
Titre abrégé: Matrix Biol
Pays: Netherlands
ID NLM: 9432592
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
15
10
2020
revised:
08
01
2021
accepted:
11
01
2021
pubmed:
18
1
2021
medline:
14
1
2022
entrez:
17
1
2021
Statut:
ppublish
Résumé
TANK-binding kinase 1 (TBK1) is a druggable multifunctional kinase that exerts a broad spectrum of functions in cells. These range from innate immunity, inflammation and interferon (IFN) signaling, through selective autophagy, specifically mitophagy and xenophagy, to energy homeostasis. Thus, it is not surprising that TBK1 is involved in many cellular signaling pathways that contribute to diverse pathologies. In this review the role of TBK1 in autophagic signaling, especially mitophagy and xenophagy, and its contribution to oncogenesis or neurodegenerative diseases will be discussed.
Identifiants
pubmed: 33454423
pii: S0945-053X(21)00005-6
doi: 10.1016/j.matbio.2021.01.004
pii:
doi:
Substances chimiques
Protein Serine-Threonine Kinases
EC 2.7.11.1
TBK1 protein, human
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
84-98Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.