Evaluation of the cellular protection by novel spiropyrazole compounds in dopaminergic cell death.
Cell Death
/ drug effects
Cell Survival
/ drug effects
Cytoprotection
/ drug effects
Dopaminergic Neurons
/ drug effects
Dose-Response Relationship, Drug
Humans
Molecular Structure
Neuroprotective Agents
/ chemical synthesis
Pyrazoles
/ chemical synthesis
Spiro Compounds
/ chemical synthesis
Structure-Activity Relationship
Tumor Cells, Cultured
Knoevenagel condensation
Michael addition
Neurodegeneration
Spiropyrazole
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
05 Mar 2021
05 Mar 2021
Historique:
received:
20
10
2020
revised:
09
12
2020
accepted:
24
12
2020
pubmed:
18
1
2021
medline:
1
5
2021
entrez:
17
1
2021
Statut:
ppublish
Résumé
The loss of neurons is strongly correlated with aging and aging-associated disorders. In this study, cell viability assays and mitochondrial function were performed to evaluate the effect of new spiro-pyrazole derivatives, prepared from aldehydes and 3-amino-1-phenyl-2-pyrazolin-5-one, on neuroprotection in an in vitro model of dopaminergic cell death induced by 1-methyl-4-phenylpyridinium (MPP
Identifiants
pubmed: 33454549
pii: S0223-5234(20)31112-0
doi: 10.1016/j.ejmech.2020.113140
pii:
doi:
Substances chimiques
Neuroprotective Agents
0
Pyrazoles
0
Spiro Compounds
0
pyrazole
3QD5KJZ7ZJ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113140Informations de copyright
Copyright © 2020 Elsevier Masson SAS. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.