A mucosal immune response induced by oral administration of heat-killed Mycobacterium avium subsp. paratuberculosis exacerbates EAE.
Active experimental autoimmune encephalomyelitis
C57BL/6J mouse
Gut-brain axis
Mucosal immunity
Mycobacterium avium subsp. paratuberculosis
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 03 2021
15 03 2021
Historique:
received:
03
12
2020
revised:
25
12
2020
accepted:
04
01
2021
pubmed:
18
1
2021
medline:
22
5
2021
entrez:
17
1
2021
Statut:
ppublish
Résumé
Findings in humans and animals have demonstrated a potential role for Mycobacterium avium subsp. paratuberculosis (MAP) antigenic components in encephalitogenic T cell activation. Here we reported that oral administration of MAP activates the mucosal immunity and exacerbates active experimental autoimmune encephalomyelitis (EAE) in C57BL/6J mice, modulating the immune cell traffic from secondary lymphoid organs to central nervous system. The detection of antigenic mycobacterial components by intestinal antigen-presenting cells may modulate the immune system and the subsequent inflammatory status through various signaling mechanisms, including the synthesis of pro-inflammatory cytokines involved in EAE pathogenesis.
Identifiants
pubmed: 33454553
pii: S0165-5728(21)00004-7
doi: 10.1016/j.jneuroim.2021.577477
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
577477Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.