Coronary artery lumen volume index as a marker of flow-limiting atherosclerosis-validation against
Computed tomography angiography
Myocardial ischemia
Positron emission tomography
Journal
European radiology
ISSN: 1432-1084
Titre abrégé: Eur Radiol
Pays: Germany
ID NLM: 9114774
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
03
08
2020
accepted:
01
12
2020
revised:
02
11
2020
pubmed:
18
1
2021
medline:
24
6
2021
entrez:
17
1
2021
Statut:
ppublish
Résumé
Coronary artery volume indexed to left myocardial mass (CAVi), derived from coronary computed tomography angiography (CCTA), has been proposed as an indicator of diffuse atherosclerosis. We investigated the association of CAVi with quantitative flow parameters and its ability to predict ischemia as derived from Sixty patients who underwent hybrid CCTA/PET-MPI due to suspected CAD were retrospectively included. CAVi was defined as total coronary artery lumen volume over myocardial mass, both derived from CCTA. From PET-MPI, quantitative stress and rest myocardial blood flow (MBF) and myocardial flow reserve (MFR) were obtained and correlated with CAVi, and semi-quantitative perfusion images were analyzed for the presence of ischemia. Harrell's c-statistic and net reclassification improvement (NRI) analysis were performed to evaluate the incremental value of CAVi over the CCTA model (i.e., stenosis > 50% and > 70%). CAVi correlated moderately with stress MBF and MFR (R = 0.50, p < 0.001, and R = 0.39, p = 0.002). Mean stress MBF and MFR were lower in patients with low (i.e., ≤ 20.2 mm CAVi exhibits incremental value to predict both abnormal stress MBF and ischemia over CCTA alone. • Coronary artery volume indexed to left myocardial mass (CAVi), derived from coronary computed tomography angiography (CCTA), is correlated with myocardial blood flow indices derived from
Identifiants
pubmed: 33454800
doi: 10.1007/s00330-020-07586-y
pii: 10.1007/s00330-020-07586-y
pmc: PMC8213544
doi:
Substances chimiques
Ammonia
7664-41-7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5116-5126Références
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