Concurrent cavitary pulmonary tuberculosis and COVID-19 pneumonia with in vitro immune cell anergy.
COVID-19
IGRA test
SARS-CoV-2
Tuberculosis
Journal
Infection
ISSN: 1439-0973
Titre abrégé: Infection
Pays: Germany
ID NLM: 0365307
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
24
06
2020
accepted:
02
01
2021
pubmed:
18
1
2021
medline:
26
11
2021
entrez:
17
1
2021
Statut:
ppublish
Résumé
Tuberculosis (TB) is top infectious disease killer caused by a single organism responsible for 1.5 million deaths in 2018. Both COVID-19 and the pandemic response are risking to affect control measures for TB and continuity of essential services for people affected by this infection in western countries and even more in developing countries. Knowledge about concomitant pulmonary TB and COVID-19 is extremely limited. The double burden of these two diseases can have devastating effects. Here, we describe from both the clinical and the immunological point of view a case of a patient with in vitro immune cell anergy affected by bilateral cavitary pulmonary TB and subsequent COVID-19-associated pneumonia with a worst outcome. COVID-19 can be a precipitating factor in TB respiratory failure and, during ongoing SARS-COV-2 pandemic, clinicians must be aware of this possible co-infection in differential diagnosis of patients with active TB and new or worsening chest imaging.
Identifiants
pubmed: 33454928
doi: 10.1007/s15010-021-01576-y
pii: 10.1007/s15010-021-01576-y
pmc: PMC7811686
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1061-1064Subventions
Organisme : Ministero della Salute (IT)
ID : Ricerca Corrente, Research programme n.4: tuberculosis.
Informations de copyright
© 2021. Springer-Verlag GmbH, DE part of Springer Nature.
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