Cytotoxicity and Antibacterial Activity of Alginate Hydrogel Containing Nitric Oxide Donor and Silver Nanoparticles for Topical Applications.
S-nitrosothiol
alginate hydrogel
cytotoxicity
multiresistant bacteria
nitric oxide
silver nanoparticles
Journal
ACS biomaterials science & engineering
ISSN: 2373-9878
Titre abrégé: ACS Biomater Sci Eng
Pays: United States
ID NLM: 101654670
Informations de publication
Date de publication:
13 04 2020
13 04 2020
Historique:
entrez:
18
1
2021
pubmed:
19
1
2021
medline:
11
5
2021
Statut:
ppublish
Résumé
Nitric oxide (NO) and silver nanoparticles (AgNPs) are well-known for their antibacterial activity. In this work, S-nitroso-mercaptosuccinic acid (S-nitroso-MSA), a NO donor, and green tea synthesized AgNPs were individually or simultaneously incorporated into alginate hydrogel for topical antibacterial applications. The obtained hydrogels were characterized and the NO release and diffusion of AgNPs and S-nitroso-MSA from alginate hydrogels were investigated. The hydrogels showed a concentration dependent toxicity toward Vero cells. The potent antibacterial effect of the hydrogels was demonstrated toward
Identifiants
pubmed: 33455338
doi: 10.1021/acsbiomaterials.9b01685
doi:
Substances chimiques
Alginates
0
Anti-Bacterial Agents
0
Hydrogels
0
Nitric Oxide Donors
0
Silver
3M4G523W1G
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM