The effect of atorvastatin on the common carotid artery intima-media thickness in patients with ischemic stroke.
Atorvastatin
/ pharmacology
Brain Ischemia
/ diagnostic imaging
Carotid Arteries
/ diagnostic imaging
Carotid Artery, Common
/ diagnostic imaging
Carotid Intima-Media Thickness
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/ pharmacology
Ischemic Stroke
Prospective Studies
Risk Factors
Stroke
/ drug therapy
Atorvastatin
Common carotid artery
Intima-media thickness
Stroke
Journal
Acta clinica Croatica
ISSN: 1333-9451
Titre abrégé: Acta Clin Croat
Pays: Croatia
ID NLM: 9425483
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
entrez:
18
1
2021
pubmed:
19
1
2021
medline:
26
1
2021
Statut:
ppublish
Résumé
Occlusion of the initial segment of internal carotid artery is the most common reason for vascular events in the brain. The purpose of this study was to investigate the effect of one-year treatment with atorvastatin on intima-media thickness (IMT) of carotid arteries as a measure of atherosclerosis in stroke patients. In this prospective interventional study, 44 patients with ischemic stroke were investigated. Patients were treated with atorvastatin 40 mg once a day for one year. IMT of carotid arteries was measured by extracranial Doppler ultrasonography in the distal part of the common carotid artery at the beginning of the study, at 6 months and one year of treatment with atorvastatin. The IMT of both right and left carotid arteries decreased after 6- and 12-month atorvastatin treatment. Based on the results of this study, long-term administration of atorvastatin was associated with reduction in carotid artery IMT in patients with ischemic stroke. Such a decrease in IMT may prevent subsequent stroke or cardiovascular events in these patients.
Identifiants
pubmed: 33456108
doi: 10.20471/acc.2020.59.02.04
pii: acc-59-223
pmc: PMC7808223
doi:
Substances chimiques
Hydroxymethylglutaryl-CoA Reductase Inhibitors
0
Atorvastatin
A0JWA85V8F
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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